Keith Zientek
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View article: GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination
GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination Open
DNA double-strand break (DSB) repair via homologous recombination (HR) is critical for maintaining genomic integrity and requires proper DNA end resection to generate single-stranded DNA (ssDNA) overhangs. However, the mechanisms governing…
View article: Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications
Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications Open
These data indicate a high level of conformity between rhesus macaque and human lens proteomes, and a few key differences. We identified several age-related differences in protein solubility and PTM that may contribute to lens pathology.
View article: Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter
Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter Open
Crystallin proteins serve as both essential structural and as well as protective components of the ocular lens and are required for the transparency and light refraction properties of the organ. The mouse lens crystallin proteome is repres…
View article: Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans
Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans Open
Overall, our findings reveal that the addition of AF to plasma enhances coagulation in a manner dependent on phospholipids as well as the presence of proteases and other proteins that directly regulate coagulation. We describe a correlatio…
View article: Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin
Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin Open
Crystallin proteins serve as both essential structural and as well as protective components of the ocular lens and are required for the transparency and light refraction properties of the organ. The mouse lens crystallin proteome is repres…
View article: Author Correction: The amniotic fluid proteome changes across gestation in humans and rhesus macaques
Author Correction: The amniotic fluid proteome changes across gestation in humans and rhesus macaques Open
View article: The amniotic fluid proteome changes across gestation in humans and rhesus macaques
The amniotic fluid proteome changes across gestation in humans and rhesus macaques Open
Amniotic fluid is a complex biological medium that offers protection to the fetus and plays a key role in normal fetal nutrition, organogenesis, and potentially fetal programming. Amniotic fluid is also critically involved in longitudinall…
View article: Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models
Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models Open
View article: Characterization of extracellular matrix deposited by segmental trabecular meshwork cells
Characterization of extracellular matrix deposited by segmental trabecular meshwork cells Open
View article: Characterization of extracellular matrix deposited by segmental trabecular meshwork cells
Characterization of extracellular matrix deposited by segmental trabecular meshwork cells Open
Biophysical and biochemical attributes of the extracellular matrix are major determinants of cell fate in homeostasis and disease. Ocular hypertension and glaucoma are diseases where the trabecular meshwork tissue responsible for aqueous h…
View article: Impact of α-crystallin protein loss on zebrafish lens development
Impact of α-crystallin protein loss on zebrafish lens development Open
View article: Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity Open
Low-density lipoprotein (LDL) contributes to atherogenesis and cardiovascular disease through interactions with peripheral blood cells, especially platelets. However, mechanisms by which LDL affects platelet activation and atherothrombosis…
View article: Compositional Analysis of Extracellular Aggregates in the Eyes of Patients With Exfoliation Syndrome and Exfoliation Glaucoma
Compositional Analysis of Extracellular Aggregates in the Eyes of Patients With Exfoliation Syndrome and Exfoliation Glaucoma Open
This analysis verified the presence of suspected XFM proteins and identified novel components. Quantitative comparisons between patient samples revealed a consistent XFM proteome characterized by strong expression of fibrillin-1, lysyl oxi…
View article: Effects of α-crystallin gene knockout on zebrafish lens development
Effects of α-crystallin gene knockout on zebrafish lens development Open
The α-crystallin small heat shock proteins contribute to the transparency and refractive properties of the vertebrate eye lens and prevent the protein aggregation that would otherwise produce lens cataracts, the leading cause of human blin…
View article: Upon oxidation, deamidated gammaS-crystallin has increased aggregation compared to wild type gammaS-crystallin
Upon oxidation, deamidated gammaS-crystallin has increased aggregation compared to wild type gammaS-crystallin Open
View article: Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER
Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER Open
View article: Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation
Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation Open
Collagen is the most abundant protein in humans and is heavily post-translationally modified. Its biosynthesis is very complex and requires three different types of hydroxylation (two for proline and one for lysine) that are generated in t…
View article: Post-translational modification of type IV collagen with 3-hydroxyproline affects its interactions with glycoprotein VI and nidogens 1 and 2
Post-translational modification of type IV collagen with 3-hydroxyproline affects its interactions with glycoprotein VI and nidogens 1 and 2 Open
View article: Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor
Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor Open
Key Points Activated factor XI binds and proteolyzes tissue factor pathway inhibitor. Activated factor XI promotes factor X activation generation and fibrin formation through the inactivation of tissue factor pathway inhibitor from platele…