Keito Suzuki
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View article: A Case of Pleurisy as Immune-related Adverse Events of Neoadjuvant Nivolumab and Chemotherapy After Lobectomy
A Case of Pleurisy as Immune-related Adverse Events of Neoadjuvant Nivolumab and Chemotherapy After Lobectomy Open
背景.近年,免疫チェックポイント阻害薬(immune checkpoint inhibitor:ICI)は非小細胞肺癌の術前補助化学療法(neoadjuvant chemotherapy:NAC)に使用されるようになった.肺癌診療医は過去に様々な免疫関連有害事象(immune-related adverse events:irAE)を経験してきたが,irAEとしての胸膜炎は稀であり,ICIを併用したNAC後に発症した報告はない.症例.63歳男性.右上葉肺扁平上皮癌(cT2a…
View article: Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer
Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer Open
Background The efficacy of anti‐CTLA‐4 antibody (ipilimumab) plus anti‐programmed cell death 1 antibody (nivolumab) in treating advanced non‐small cell lung cancer (NSCLC) is impeded by an elevated risk of severe immune‐related adverse eve…
View article: Magnetic resonance elastography for the prediction of hepatocellular carcinoma in chronic hepatitis B
Magnetic resonance elastography for the prediction of hepatocellular carcinoma in chronic hepatitis B Open
Background and Aim Magnetic resonance elastography (MRE) is used for the evaluation of liver fibrosis; however, it remains unclear whether MRE‐based liver stiffness is associated with hepatocellular carcinoma (HCC) development, particularl…
View article: Successful Treatment of Mucus Plug Due to Allergic Bronchopulmonary Aspergillosis Using Dupilumab
Successful Treatment of Mucus Plug Due to Allergic Bronchopulmonary Aspergillosis Using Dupilumab Open
View article: Sputum colour: An indicator of <i>Legionella pneumophila</i> pneumonia
Sputum colour: An indicator of <i>Legionella pneumophila</i> pneumonia Open
Key message The sputum colour in patients with severe pneumonia needs to be considered during diagnosis.
View article: A Case of <i>ROS1</i> Fusion Gene-positive Lung Adenocarcinoma Diagnosed After Pulmonary Thromboembolism
A Case of <i>ROS1</i> Fusion Gene-positive Lung Adenocarcinoma Diagnosed After Pulmonary Thromboembolism Open
背景.ROS1融合遺伝子陽性肺癌(以下,ROS1肺癌)は非小細胞肺癌の1~2%であり,希少な遺伝子変異である.ROS1肺癌は若年者,女性,非喫煙者に多く,病理学的に粘液を有する腺癌が多い.非小細胞肺癌は血栓塞栓症の発生率が増加するが,さらにROS1肺癌は血栓症リスクが上昇する.本症例は肺血栓塞栓症を契機にROS1肺癌と診断された.症例.46歳の男性が息切れと両下腿の疼痛のため受診した.造影CTで肺動脈および左大腿静脈に血栓と,右中葉に結節影と縦隔リンパ節腫脹を認めた.肺血栓…
View article: Drop finger caused by lung cancer metastasis
Drop finger caused by lung cancer metastasis Open
Skeletal muscle metastasis of lung cancer is rare. However, clinicians should be aware that tumour‐induced nerve compression symptoms may develop.
View article: Cytokine Releasing Syndrome Following Pleurodesis During Combination Chemo-immunotherapy for Lung Adenocarcinoma
Cytokine Releasing Syndrome Following Pleurodesis During Combination Chemo-immunotherapy for Lung Adenocarcinoma Open
背景.免疫チェックポイント阻害薬(immune checkpoint inhibitor;ICI)と化学療法の併用において,最も重篤な免疫関連有害事象(immune related adverse event;irAE)の一つにサイトカイン放出症候群(cytokine releasing syndrome;CRS)がある.CRSは生命を脅かす高炎症病態で発熱や多臓器不全を呈する.重症化を防ぐためにも早期治療介入が重要である.症例.72歳 男性.右下葉肺腺癌に対して手術が施行…
View article: Invasive Mucinous Adenocarcinoma Diagnosed Using Transbronchial Cryobiopsy
Invasive Mucinous Adenocarcinoma Diagnosed Using Transbronchial Cryobiopsy Open
Invasive mucinous adenocarcinoma (IMA) is a subtype of lung adenocarcinoma with a poor prognosis. Delays in diagnosis and treatment are problematic due to the nonspecific symptoms of cough and sputum and the difficulty of diagnosis by bron…
View article: A Comparison of Alanine Aminotransferase Normalization between Pemafibrate and Bezafibrate in Patients with Nonalcoholic Fatty Liver Disease
A Comparison of Alanine Aminotransferase Normalization between Pemafibrate and Bezafibrate in Patients with Nonalcoholic Fatty Liver Disease Open
Objective Pemafibrate is a recently developed selective peroxisome proliferator-activated receptor alpha modulator that can improve alanine aminotransferase (ALT) levels in patients with nonalcoholic fatty liver disease (NAFLD). However, t…
View article: Effects of maslinic acid supplementation on exercise-induced inflammation and oxidative stress in water polo athletes: A randomized, double-blind, crossover, and placebo-controlled trial
Effects of maslinic acid supplementation on exercise-induced inflammation and oxidative stress in water polo athletes: A randomized, double-blind, crossover, and placebo-controlled trial Open
These findings suggest that MA intake not only reduces perceptual fatigue and muscle soreness but also decreases inflammation and oxidative stress in the blood and skeletal muscle.
View article: Switching from entecavir to tenofovir alafenamide for maintaining complete virological response in chronic hepatitis B
Switching from entecavir to tenofovir alafenamide for maintaining complete virological response in chronic hepatitis B Open
Background and Aim Hepatocellular carcinoma development can be decreased by achieving and maintaining complete virological response (CVR) in chronic hepatitis B. However, it is unclear whether switching from entecavir (ETV) to tenofovir al…
View article: Pemigatinib treatment for intrahepatic cholangiocarcinoma with <scp>FGFR2</scp> fusion detected by a liquid comprehensive genomic profiling test
Pemigatinib treatment for intrahepatic cholangiocarcinoma with <span>FGFR2</span> fusion detected by a liquid comprehensive genomic profiling test Open
Key Clinical Message The liquid CGP was useful for detecting FGFR2 fusion and the patient experienced typical side effects (nail disorders, hyperphosphatemia, and taste disorders) of pemigatinib that required treatment.
View article: Relationship between immune‐related adverse events and treatment effectiveness in extensive disease small cell lung cancer
Relationship between immune‐related adverse events and treatment effectiveness in extensive disease small cell lung cancer Open
Background This study aimed to assess the relationship between immune response adverse events (irAEs) and treatment efficacy in patients with extensive disease small cell lung cancer (ED‐SCLC). Methods We retrospectively evaluated the clin…
View article: Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease Open
View article: Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test
Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test Open
Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling testShun Ishido¹*, Nobuharu Tamaki¹*, Kento Inada¹, Jun Itakura¹, Yuka Takahashi¹, Naoki Uchihara¹, Keito Suzu…
View article: Two Cases of Immune-Related ACTH Deficiency after the Initiation of Atezolizumab plus Bevacizumab for Multiple Hepatocellular Carcinoma
Two Cases of Immune-Related ACTH Deficiency after the Initiation of Atezolizumab plus Bevacizumab for Multiple Hepatocellular Carcinoma Open
Background: There have been a few case reports of immune-related Adrenocorticotropic Hormone (ACTH) deficiency in cases of atezolizumab plus bevacizumab therapy for unresectable HCC.Our report aims to enhance comprehension of immune-relate…
View article: Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease Open
Background: Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aime…
View article: Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma
Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma Open
This study aimed to investigate the clinical usefulness of comprehensive genomic profiling (CGP) in patients with unresectable hepatocellular carcinoma who received multiple systemic therapies in real-world practice. In this study, all nin…
View article: Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma
Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma Open
Background: Sarcopenia is associated with overall survival in patients with hepatocellular carcinoma (HCC). However, it is not known whether muscle volume is associated with clinical outcomes during combination therapy with immune checkpoi…