Explanipedia

Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study Open

Qingli Mu, Kejing Zhang, Y. Chen, Yihua Xu, Shaohua Hu , et al. · 2025

Previous studies have found that major depressive disorder (MDD) may accelerate overall structural brain aging. Nevertheless, it still remains unknown whether anhedonia, a critical negative prognostic indicator in MDD, further leads to adv…

Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study Open

Yin Zhou, Yuxiao Chen, Pengli Wang, Kejing Zhang, Yili Zhang · 2025

Objective Schizophrenia is a globally prevalent complex neuropsychiatric disorder that is frequently comorbid with various psychiatric disorders, leading to poor prognoses for affected patients. However, the causal relationships between sc…

Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume Open

Weijia Gao, Kejing Zhang, Qing Jiao, Linyan Su, Dong Cui , et al. · 2025

Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice Open

Guoyan Li, Jingbo Liu, Kejing Zhang · 2025

Sleep deprivation (SD) is known to induce neurocognitive dysfunction, with hippocampal inflammation emerging as a critical mediator. Electroacupuncture has shown efficacy in modulating inflammation in neurological disorders, but its potent…

Abnormal Structure–Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia Open

Qingli Mu, Congchong Wu, Y. Chen, Yihua Xu, Kejing Zhang , et al. · 2025

Background: As a core symptom of major depressive disorder (MDD), previous magnetic resonance studies have demonstrated that MDD with anhedonia may exhibit distinctive brain structural and functional alterations. Nevertheless, the impact o…

Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission Open

Wei Zhang, Lei Bai, Wentao Xu, Junping Liu, Yi Chen , et al. · 2024

The degeneration of the neuromuscular junction (NMJ) and the decline in motor function are common features of aging, but the underlying mechanisms have remained largely unclear. This study reveals that Sirt6 is reduced in aged mouse muscle…

Local protein synthesis at neuromuscular synapses is required for motor functions Open

Wen-Yo Tu, Wentao Xu, Lei Bai, Jun Liu, Yi Han , et al. · 2024

Motor neurons are highly polarized, and their axons extend over great distances to form connections with myofibers via neuromuscular junctions (NMJs). Local translation at the NMJs in vivo has not been identified. Here, we utilized motor n…

Adjusting the Covalency of Metal‐Oxygen Bonds in CuBi<sub>2</sub>O<sub>4</sub> by Zn Cation Doping to Achieve Highly Efficient Photocathodes Open

Yuheng Zhang, Yusheng Xu, Kejing Zhang, Zhixue Li, Zeze Lin , et al. · 2024

Zn doped CuBi 2 O 4 photocathodes are prepared by using a low‐cost solution‐based spray pyrolysis method. The doping of Zn in CuBi 2 O 4 promotes the separation and migration of carriers and effectively increases the carrier density. Compa…

Control of cyanobacterial growth with potassium; implications for bloom control in nuclear storage ponds Open

Kejing Zhang, Lynn Foster, Christopher Boothman, Naji M. Bassil, Jon K. Pittman , et al. · 2024

Microbial blooms have been reported in the First Generation Magnox Storage Pond at the Sellafield Nuclear Facility. The pond is kept alkaline with NaOH to minimise fuel rod corrosion, however alkali-tolerant microbial blooms dominated by t…

Pb Alleviates as Mobilization During the Biological Reductive Dissolution of Pb-As Jarosite Open

Tingzheng Zhang, Kejing Zhang, Qingcai Liu, Weizao Liu, Chunlian Ding , et al. · 2024

Pb Alleviates as Mobilization During the Biological Reductive Dissolution of Pb-As Jarosite Open

Tingzheng Zhang, Kejing Zhang, Chunlian Ding, Qingcai Liu, Weizao Liu , et al. · 2024

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome Open

Xiaoqiu Shu, Wei Chen, Wen-Yo Tu, Keke Zhong, Shuyuan Qi , et al. · 2023

Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form of dipeptide repeat proteins (DP…

Biohybrids Of Twinning Cd0.8zn0.2s Nanoparticles and Sporomusa Ovata For Efficient Solar-Driven Reduction Of Co2 To Acetate Open

Kejing Zhang, Ruijie Li, Jianxin Chen, Liyuan Chai, Zhang Lin , et al. · 2023

C9orf72 poly-GA proteins impair neuromuscular transmission Open

Wen-Yo Tu, Wentao Xu, Jianmin Zhang, Shuyuan Qi, Lei Bai , et al. · 2023

Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease, in which lower motoneurons lose control of skeletal muscles. Degeneration of neuromuscular junctions (NMJs) occurs at the initial stage of ALS. Dipeptide repeat prote…

The interplay between Cs and K in Pseudanabaena catenata; from microbial bloom control strategies to bioremediation options for radioactive waters Open

Kejing Zhang, Lynn Foster, Dawn Buchanan, Victoria S. Coker, Jon K. Pittman , et al. · 2022

Pseudanabaena dominates cyanobacterial blooms in the First-Generation Magnox Storage Pond (FGMSP) at a UK nuclear site. The fission product Cs is a radiologically significant radionuclide in the pond, and understanding the interactions bet…

Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers Open

Lei Bai, Wen-Yo Tu, Yatao Xiao, Kejing Zhang, Chengyong Shen · 2022

Genetic Variations within the Bovine CRY2 Gene Are Significantly Associated with Carcass Traits Open

Xuelan Li, Enhui Jiang, Kejing Zhang, Sihuan Zhang, Fugui Jiang , et al. · 2022

As an important part of the circadian rhythm, the circadian regulation factor 2 of cryptochrome (CRY2), regulates many physiological functions. Previous studies have reported that CRY2 is involved in growth and development. However, the re…

Human neuromuscular junction three-dimensional organoid models and the insight in motor disorders Open

Kejing Zhang, Lei Bai, Wentao Xu, Chengyong Shen · 2021

The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated in various motor disorders. Because of their large size and eas…

UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model Open

Kejing Zhang, Wang Ailian, Keke Zhong, Shuyuan Qi, Wei Chen , et al. · 2021

Biomineralization of Sr by the Cyanobacterium Pseudanabaena catenata Under Alkaline Conditions Open

Lynn Foster, Katherine Morris, Adrian Cleary, Heath Bagshaw, David C. Sigee , et al. · 2020

A non-axenic culture of Pseudanabaena catenata, a close relative of the bloom-forming cyanobacterium found in the high pH First Generation Magnox Storage Pond at the Sellafield Nuclear Facility, was supplemented with 1 mM of SrCl2, to dete…

Utilization of all components in biomass through high reducing sugar production and lignin nanoparticles preparation Open

Wei Liu, Shengnan Zhuo, Xianfa Su, Mengying Si, Kejing Zhang , et al. · 2019

BackgroundLignocellulosic biomass for biofuel production was considered as an effective way to develop new energy. However, the efficient sugar conversion of cellulose and practical utilization of lignin are great challenges for sustainabl…

Motoneuron Wnts regulate neuromuscular junction development Open

Chengyong Shen, Lei Li, Kai Zhao, Lei Bai, Ailian Wang , et al. · 2018

The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less is known about mechanisms of presynaptic assembly. Genetic…

Author response: Motoneuron Wnts regulate neuromuscular junction development Open

Chengyong Shen, Lei Li, Kai Zhao, Lei Bai, Ailian Wang , et al. · 2018

Kejing Zhang YOU? Author Swipe