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View article: Daptomycin versus beta-lactam based therapy for the treatment of enterococcal endocarditis and other endovascular infections: a retrospective cohort study
Daptomycin versus beta-lactam based therapy for the treatment of enterococcal endocarditis and other endovascular infections: a retrospective cohort study Open
Outcomes were similar among patients with EIE treated with daptomycin versus beta-lactams. Larger, prospective studies are needed to confirm this finding.
View article: P-207. Implementation of Two-Step <i>C. difficile</i> Testing to Reduce HO-CDI and Antibiotic Use with Analysis of Ordering and Treatment Practices
P-207. Implementation of Two-Step <i>C. difficile</i> Testing to Reduce HO-CDI and Antibiotic Use with Analysis of Ordering and Treatment Practices Open
Background C. difficile infection (CDI) is an ongoing challenge for healthcare facilities. The mischaracterization of C. difficile colonization as active infection falsely elevates healthcare onset-CDI (HO-CDI) rates and increases antimicr…
View article: Speed, Spectrum, and Satisfaction: Assessment of an Infectious Diseases eConsult Program
Speed, Spectrum, and Satisfaction: Assessment of an Infectious Diseases eConsult Program Open
This report examines the implementation and early functioning of a new infectious diseases (ID) eConsult program. We recorded the reasons for placing ID eConsults, time to eConsult completion, in-person clinic wait times, and referring pro…
View article: 599. Association between Vancomycin AUC and Clinical Failure in Patients with Streptococcal Bacteremia
599. Association between Vancomycin AUC and Clinical Failure in Patients with Streptococcal Bacteremia Open
Background Vancomycin (VAN) is an efficacious therapy against Streptococcus. VAN area under the curve to minimum inhibitory concentration (AUC/MIC) is the preferred monitoring strategy for serious methicillin-resistant S. aureus infections…
View article: Association Between Vancomycin AUC and Clinical Failure in Patients with Streptococcal Bacteremia
Association Between Vancomycin AUC and Clinical Failure in Patients with Streptococcal Bacteremia Open
Background: Monitoring of vancomycin using the area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio is now preferred for serious methicillin-resistant Staphylococcus aureus infections. Vancomycin AUC/MIC monitoring is…
View article: Impact of concomitant fluconazole on direct oral anticoagulant bleeding risk
Impact of concomitant fluconazole on direct oral anticoagulant bleeding risk Open
Study Objective The aim of this study was to evaluate the effect on bleeding risk when fluconazole is administered concomitantly with direct oral anticoagulants (DOACs). Design This was a retrospective cohort study including hospitalized a…
View article: 600. The Effect of Medication-Assisted Treatment on Completion Rates of Outpatient Parenteral Antibiotic Therapy
600. The Effect of Medication-Assisted Treatment on Completion Rates of Outpatient Parenteral Antibiotic Therapy Open
Background Injection drug use is a nationwide epidemic associated with an increased risk of invasive Staphylococcus aureus (S. aureus) infections. Medication-assisted treatment (MAT) is effective in reducing substance use and increasing ad…
View article: 307. Predictors of Respiratory Bacterial Co-Infection in Hospitalized COVID-19 Patients
307. Predictors of Respiratory Bacterial Co-Infection in Hospitalized COVID-19 Patients Open
Background COVID-19 pneumonia can be indistinguishable from other infectious respiratory etiologies, so providers are challenged with deciding whether empiric antibiotics should be prescribed to hospitalized patients with SARS-CoV-2. This …
View article: Clinical Outcomes with Ertapenem for Pneumonia in Obese versus Nonobese Patients
Clinical Outcomes with Ertapenem for Pneumonia in Obese versus Nonobese Patients Open
The objective of this study was to compare the rate of pneumonia resolution in obese (body mass index [BMI], ≥30 kg/m 2 ) and nonobese (BMI, <30 kg/m 2 ) patients treated with 1 gram ertapenem daily. In this retrospective cohort study, we …
View article: Clinical Outcomes With Definitive Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia With Retained Daptomycin and Ceftaroline Combination Therapy vs De-escalation to Monotherapy With Vancomycin, Daptomycin, or Ceftaroline
Clinical Outcomes With Definitive Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia With Retained Daptomycin and Ceftaroline Combination Therapy vs De-escalation to Monotherapy With Vancomycin, Daptomycin, or Ceftaroline Open
Background Lower mortality has been observed with combination therapy compared to monotherapy for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, there is a lack of evidence for continued combination therapy over de…
View article: Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections
Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections Open
Staphylococcus aureus (S. aureus) is the leading cause of bacteraemia and infective endocarditis worldwide. The preferred management of patients with methicillin-susceptible S. aureus (MSSA) bacteraemia includes definitive therapy with int…
View article: 272. Clinical Outcomes with Continuation of Combination Antibiotic Therapy versus De-escalation to Monotherapy for Patients with MRSA Bacteremia
272. Clinical Outcomes with Continuation of Combination Antibiotic Therapy versus De-escalation to Monotherapy for Patients with MRSA Bacteremia Open
Background Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with increased morbidity and mortality. Previous studies have demonstrated lower mortality with combination therapy (CT) compared to monother…
View article: 575. Effectiveness of Short vs Long Course Perioperative Antibiotics in Lung Transplant Recipients with Donor Positive Respiratory Cultures
575. Effectiveness of Short vs Long Course Perioperative Antibiotics in Lung Transplant Recipients with Donor Positive Respiratory Cultures Open
Background Lung transplant recipients are at increased risk for infection in the early post-operative phase. Perioperative antibiotic (POA) practices are variable among transplant centers with sparse data regarding optimal antibiotic proph…
View article: 722. Effectiveness of Fidaxomicin versus Oral Vancomycin in the Treatment of Recurrent <i>Clostridioides difficile</i>
722. Effectiveness of Fidaxomicin versus Oral Vancomycin in the Treatment of Recurrent <i>Clostridioides difficile</i> Open
Background The 2017 IDSA/SHEA clinical practice guidelines for Clostridioides difficile infection (CDI) recommend treating recurrent episodes with fidaxomicin or oral vancomycin, but there is little evidence to support one strategy over an…
View article: Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of Clostridioides difficile Infection in Patients with Discordant Diagnostic Test Results
Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of Clostridioides difficile Infection in Patients with Discordant Diagnostic Test Results Open
Clostridioides difficile infection (CDI) is one of the most common health care-associated infections that can cause significant morbidity and mortality. CDI diagnosis involves laboratory testing in conjunction with clinical assessment. The…
View article: Clinical Impact of an Antibiotic Time Out Initiative at an Academic Medical Center
Clinical Impact of an Antibiotic Time Out Initiative at an Academic Medical Center Open
Background: Various strategies aimed at limiting inappropriate antimicrobial use including antibiotic time out (ATO) have been proposed to combat the development of antimicrobial resistance, yet there are limited studies that have assessed…
View article: 177. Clinical Outcomes of Daptomycin vs. Anti-Staphylococcal β-Lactams in Definitive Treatment of Methicillin-Susceptible Staphylococcus aureus (MSSA) Bloodstream Infections
177. Clinical Outcomes of Daptomycin vs. Anti-Staphylococcal β-Lactams in Definitive Treatment of Methicillin-Susceptible Staphylococcus aureus (MSSA) Bloodstream Infections Open
Background The preferred management of patients with MSSA bacteremia includes definitive therapy with intravenous anti-staphylococcal β-lactam antibiotics. In β-lactam allergic or intolerant patients, daptomycin has been targeted as a viab…
View article: 1036. Clinical impact of an antibiotic time out initiative at an academic medical center
1036. Clinical impact of an antibiotic time out initiative at an academic medical center Open
Background The Infectious Diseases Society of America’s guideline for implementing antibiotic (abx) stewardship recommends routine review of abx use. Several studies demonstrate antibiotic time out (ATO) programs result in de-escalation, b…
View article: 2265. Clinical Outcomes with Single vs. Combination Antibiotic Therapy in the Treatment of Burkholderia cepacia complex Bacteremia and Pneumonia
2265. Clinical Outcomes with Single vs. Combination Antibiotic Therapy in the Treatment of Burkholderia cepacia complex Bacteremia and Pneumonia Open
Background Burkholderia cepacia complex (Burkholderia cenocepacia and Burkholderia multivorans) (BCC) are uncommon, yet serious often drug-resistant pathogens of immunocompromised patients, especially in lung transplants; pre-operative inf…
View article: 1484. Impact of Combination Vs. Monotherapy on Clinical Outcomes Associated with <i>Stenotrophomonas maltophilia</i> Pneumonia
1484. Impact of Combination Vs. Monotherapy on Clinical Outcomes Associated with <i>Stenotrophomonas maltophilia</i> Pneumonia Open
BACKGROUND: Stenotrophomonas maltophilia is an emerging nosocomial pathogen with intrinsic resistance to several antibiotics, making it potentially challenging to treat. Studies have demonstrated treatment failures and resistance developme…