Explanipedia

709 A novel mouse model to investigate the impact of B cell-driven immunity in immunotherapy-treated non-small cell lung cancer Open

Alessandra Vaccaro, Xin Sun, Armando J Ruiz-Justiz, Michael Wang, Cheuk Hong Leung , et al. · 2025

113P Venous thromboembolism (VTE) prophylaxis in patients with epithelial ovarian cancer undergoing neoadjuvant chemotherapy with carboplatin and paclitaxel Open

Humera Sarwar, Neil Ryan, Nadeem Zafar, Kelli A. Connolly · 2025

94P PRIMA vs real-world data: Patient characteristics and cancer outcomes Open

Sze Shin Low, S. Coulter, Alison A. McCormick, Jennifer R. Brown, Kelli A. Connolly , et al. · 2025

Preclinical Models of Solid Cancers for Testing Cancer Immunotherapies Open

Francisco Expósito, Kelli A. Connolly, Tang Tang, Michael Chiorazzi, Brian G. Hunt , et al. · 2025

Preclinical models have played a pivotal role in the development of immunotherapies that now have become a standard treatment option for numerous cancer types. This review examines the strengths and weaknesses of various mouse models in ad…

Distinct T Cell Functions Enable Efficient Immunoediting and Prevent Tumor Growth in Developing Sarcomas Open

Julie F. Cheung, Shudipto Wahed, Elaine Cheng, Kelli A. Connolly, Brian G. Hunt , et al. · 2024

A Perfect Fit: 3D-Printed Kit to Teach Students Principles of Antigen-Antibody Recognition and Herd Immunity Open

Sarah Ohashi, Lindsey D. Hughes, Kelli A. Connolly, Jennifer Wang, Sofia Velazquez , et al. · 2023

The immunological principles underlying vaccines are a critical part of understanding human health and disease, but are typically not included in general K-12 education curriculum. The COVID-19 pandemic has underscored both the power of sc…

Novel Mouse Models for Cancer Immunology Open

Kelli A. Connolly, Brittany Fitzgerald, Martina Damo, Nikhil S. Joshi · 2022

Mouse models of cancer immunology provide excellent systems in which to study and test biological mechanisms of the immune response against cancer. Historically, these models were designed to have different strengths based on the current m…

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses Open

Can Cui, Jiawei Wang, Eric Fagerberg, Ping-Min Chen, Kelli A. Connolly , et al. · 2021

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response Open

Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Jiawei Wang , et al. · 2021

Tumor-specific CD8 + T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those in tumors.

A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma Open

Brittany Fitzgerald, Kelli A. Connolly, Can Cui, Eric Fagerberg, Dylan L. Mariuzza , et al. · 2021

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response Open

Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Jiawei Wang , et al. · 2021

“Stem-like” TCF1 + CD8 + T cells (T SL ) are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy but, as tumors contain signals that should drive T-cell terminal-differentiation, how these cells are ma…

A Novel Mouse Model for the Study of Anti-Tumor T Cell Responses in Kras Driven Lung Adenocarcinoma Open

Brittany Fitzgerald, Kelli A. Connolly, Can Cui, Dylan L. Mariuzza, Eric Fagerberg , et al. · 2021

Neoantigen driven B cell and CD4+T follicular helper cell collaboration promotes robust anti-tumor CD8+T cell responses Open

Can Cui, Jiawei Wang, Ping-Min Chen, Kelli A. Connolly, Martina Damo , et al. · 2020

CD4 + T follicular helper (TFH) cells provide help to B cells, which is critical for germinal center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We found TFH cells correlated with GC B cells and with…

Inducible de novo expression of neoantigens in tumor cells and mice Open

Martina Damo, Brittany Fitzgerald, Yisi Lu, Mursal Nader, Ivana William , et al. · 2020

NINJA: an inducible genetic model for creating neoantigensin vivo Open

Martina Damo, Brittany Fitzgerald, Yisi Lu, Mursal Nader, Ivana William , et al. · 2020

Mouse models with inducible neoantigens have been historically difficult to generate because of leaky expression of antigens in the thymus, which causes central tolerance in developing CD8 and CD4 T cells. Attempts to resolve this problem …

Neoantigen Driven B Cell and CD4+ T Follicular Helper Cell Collaboration Promotes Robust Anti-Tumor CD8+ T Cell Responses Open

Can Cui, Jiawei Wang, Ping-min Chen, Kelli A. Connolly, Martina Damo , et al. · 2020

A Reservoir of Stem-Like CD8 T Cells in the Tumor-Draining Lymph Node Maintains the Ongoing Anti-Tumor Immune Response Open

Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Brittany Fitzgerald , et al. · 2020

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment Open

Bradley N. Mills, Kelli A. Connolly, Jian Ye, Joseph D. Murphy, Taylor P. Uccello , et al. · 2019

Lineage Specifiers in Lung Cancer Are Ahead of Their TIME Open

Kelli A. Connolly, Brittany Fitzgerald, Nikhil S. Joshi · 2018

A murine model of micrometastatic pancreas cancer Open

Ankit Patel, Nathania M. Figueroa, Brian A. Belt, Kelli A. Connolly, Aditi Murthy , et al. · 2017

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes Open

Kelli A. Connolly, Brian A. Belt, Nathania M. Figueroa, Aditi Murthy, Ankit Patel , et al. · 2016

Although radiotherapy (RT) is widely used to control tumor growth across many cancer types, there is a relatively high incidence of RT failure exhibited by tumor recurrence, therefore a clear need exists to achieve improved effectiveness o…

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