Kellie M. Breen
YOU?
Author Swipe
View article: Prostaglandin synthesis mediates the suppression of arcuate Kiss1 neuron activation and pulsatile luteinizing hormone secretion during immune/inflammatory stress in female mice
Prostaglandin synthesis mediates the suppression of arcuate Kiss1 neuron activation and pulsatile luteinizing hormone secretion during immune/inflammatory stress in female mice Open
Stress induces a series of compensatory mechanisms with the objective of restoration or adaptation of physiological function. A common casualty of the response to stress is impaired reproduction via the inhibition of pulsatile luteinizing …
View article: Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2–CRHR2 Signaling Pathway
Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2–CRHR2 Signaling Pathway Open
Physiologic stress elicits impairment of reproductive function, in part, by the suppression of luteinizing hormone (LH) secretion. Two populations of kisspeptin-synthesizing neurons in the hypothalamus play essential roles in controlling t…
View article: Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice
Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice Open
Stress impairs fertility, at least in part, via inhibition of gonadotropin secretion. Luteinizing hormone (LH) is an important gonadotropin that is released in a pulsatile pattern in males and in females throughout the majority of the ovar…
View article: Multimorbidity in patients with acute coronary syndrome is associated with greater mortality, higher readmission rates, and increased length of stay: A systematic review
Multimorbidity in patients with acute coronary syndrome is associated with greater mortality, higher readmission rates, and increased length of stay: A systematic review Open
Objective: The aims of this systematic review were to determine the magnitude and impact of multimorbidity (≥2 chronic conditions) on mortality, length of stay, and rates of coronary intervention in patients with acute coronary syndrome (A…
View article: Multimorbidity phenotypes in patients presenting to the emergency department with possible acute coronary syndrome
Multimorbidity phenotypes in patients presenting to the emergency department with possible acute coronary syndrome Open
Background: Multimorbidity (> 2 conditions) increases the risk of adverse outcomes and challenges health care systems for patients with acute coronary syndrome (ACS). These complications may be partially attributed to ACS clinical care whi…
View article: Allostasis in Neuroendocrine Systems Controlling Reproduction
Allostasis in Neuroendocrine Systems Controlling Reproduction Open
Allostasis provides a supporting role to the homeostatic control of biological variables in mammalian species. While the concept of homeostasis is related to the control of variables within a set point or range that are essential to life, …
View article: Extracellular Matrix Influences Gene Expression and Differentiation of Mouse Trophoblast Stem Cells
Extracellular Matrix Influences Gene Expression and Differentiation of Mouse Trophoblast Stem Cells Open
Trophoblast stem (TS) cells were first isolated from the mouse placenta; however, little is known about their maintenance and niche in vivo. TS cells, like other stem cells, have a unique microenvironment in which the extracellular matrix …
View article: A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice
A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice Open
A major obstacle to monitoring pulsatile luteinizing hormone (LH) secretion in mice has been an assay with sufficient sensitivity in small blood volumes. In 2013, Steyn and colleagues published a highly sensitive enzyme-linked immunosorben…
View article: Regulation of the gonadotropin‐releasing hormone neuron during stress
Regulation of the gonadotropin‐releasing hormone neuron during stress Open
The effect of stress on reproduction and gonadal function has captivated investigators for almost 100 years. Following the identification of gonadotropin‐releasing hormone (GnRH) 50 years ago, a niche research field emerged fixated on how …
View article: Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition
Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition Open
Chronic undernutrition is a type of metabolic stress that impairs reproduction in multiple species. Although energy balance and female reproductive capacity is recognized as tightly coupled, the neuroendocrine loci and molecular mechanisms…
View article: Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Females During Chronic Undernutrition: A Mouse Model
Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Females During Chronic Undernutrition: A Mouse Model Open
Chronic undernutrition is a type of metabolic stress that impairs reproduction across species and, in women, is implicated in the development of functional hypothalamic amenorrhea. Although the tight coupling of energy balance to reproduct…
View article: Activation of Norepinephrine Neurons in the NTS (A2 population) is Sufficient to Suppress Pulsatile LH Secretion in Female Mice
Activation of Norepinephrine Neurons in the NTS (A2 population) is Sufficient to Suppress Pulsatile LH Secretion in Female Mice Open
The overarching goal of this work is to identify neural pathways underlying inhibition of pulsatile luteinizing hormone (LH) secretion during stress. Stress-induced suppression of LH secretion is mediated, at least in part, by suppression …
View article: Role of CORT Duration and Estradiol Dependence for Stress-level of CORT to Inhibit Pulsatile LH Secretion in Female Mice
Role of CORT Duration and Estradiol Dependence for Stress-level of CORT to Inhibit Pulsatile LH Secretion in Female Mice Open
Two common responses to stress include elevated circulating glucocorticoids and impaired luteinizing hormone (LH) secretion. We have shown that a chronic stress-level of corticosterone (CORT) can slow LH pulses in female mice and that this…
View article: Peripheral interleukin-1β inhibits arcuate kiss1 cells and LH pulses in female mice
Peripheral interleukin-1β inhibits arcuate kiss1 cells and LH pulses in female mice Open
Peripheral immune/inflammatory challenges rapidly disrupt reproductive neuroendocrine function. This inhibition is considered to be centrally mediated via suppression of gonadotropin-releasing hormone secretion, yet the neural pathway(s) f…
View article: SUN-257 Evidence that Urocortin 2 Contributes to the Suppressive Effect of Metabolic Stress on LH Secretion in Female Mice
SUN-257 Evidence that Urocortin 2 Contributes to the Suppressive Effect of Metabolic Stress on LH Secretion in Female Mice Open
Pulsatile luteinizing hormone (LH) secretion is disrupted by numerous stimuli including metabolic stress. Insulin-induced hypoglycemia is a model of metabolic stress that suppresses LH secretion in numerous species including mice. Our rece…
View article: Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice
Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice Open
Introduction: Two common responses to stress include elevated circulating glucocorticoids and impaired luteinizing hormone (LH) secretion. We have previously shown that a chronic stress level of corticosterone can impair ovarian cyclicity …
View article: SAT-418 Estradiol Enhances the Inhibitory Effect of the Cytokine Interleukin 1B on Pulsatile LH Secretion in Female Mice
SAT-418 Estradiol Enhances the Inhibitory Effect of the Cytokine Interleukin 1B on Pulsatile LH Secretion in Female Mice Open
Inflammatory and infectious processes can disrupt reproduction function and fertility in a wide range of species including humans, domesticated species and laboratory animals. Immune cells produce cytokines in response to systemic stressor…
View article: SAT-419 Mechanisms Underlying Glucocorticoid-Induced Suppression of Pulsatile LH: Insights from Immortalized Kisspeptin Cells
SAT-419 Mechanisms Underlying Glucocorticoid-Induced Suppression of Pulsatile LH: Insights from Immortalized Kisspeptin Cells Open
Stress inhibits fertility at least in part by inhibiting gonadotropin secretion. Part of the stress response is an increase in circulating glucocorticoid concentrations, specifically corticosterone in mice. We have demonstrated that contin…
View article: SAT-407 Evidence for Impaired Kisspeptin Signaling During Metabolic Stress in Female Mice
SAT-407 Evidence for Impaired Kisspeptin Signaling During Metabolic Stress in Female Mice Open
Stress impairs reproduction, at least in part, by suppressing gonadotropin secretion. One common metabolic stressor is hypoglycemia, which occurs in a variety of pathologies and in healthy people, particularly athletes. Insulin-induced hyp…
View article: Supplementary Material for: Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice
Supplementary Material for: Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice Open
Introduction: Two common responses to stress include elevated circulating glucocorticoids and impaired luteinizing hormone (LH) secretion. We have previously shown that a chronic stress level of corticosterone can impair ovarian cyclicity …
View article: Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion
Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion Open
In many endocrine systems, circulating factors or hormones are not released continuously, but are secreted as a discrete pulse in response to a releasing factor. Single-point sampling measures are inadequate to fully understand the biologi…
View article: Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice
Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice Open
Psychosocial stress, such as isolation and restraint, disrupts reproductive neuroendocrine activity. Here we investigate the impact of psychosocial stress on luteinizing hormone (LH) pulses and gene expression and neuronal activation withi…
View article: Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse
Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse Open
Central organization of the hypothalamic-pituitary-gonadal axis is initiated during fetal life. At this critical time, gonadal hormones mediate sex-specific development of the hypothalamic-pituitary axis, which then dictates reproductive p…