Kelly A. Cairns
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View article: Fluconazole exposure during mechanical circulatory support (MCS) device insertion
Fluconazole exposure during mechanical circulatory support (MCS) device insertion Open
In 10 patients undergoing MCS device insertion, fluconazole 200 to 400 mg IV achieved median plasma levels of between 3 and 4 mg/L throughout the surgical procedure but may not adequately cover for C. glabrata.
View article: Association between daptomycin dosing and in-hospital mortality in patients with vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection
Association between daptomycin dosing and in-hospital mortality in patients with vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection Open
Background Vancomycin-resistant Enterococcus faecium (VREfm) bloodstream infections (BSIs) pose significant management challenges with uncertainties relating to the optimal daptomycin dose for treatment. Methods A retrospective cohort stud…
View article: Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department
Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department Open
Objectives Time to initiation of effective antibiotic therapy is a strong predictor of survival for patients with sepsis presenting to the Emergency Department (ED). Antibiotic allergy labels (AALs) are a known barrier to timely sepsis man…
View article: Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections
Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections Open
Vancomycin-resistant enterococci (VRE) are common causes of bloodstream infections (BSIs) with high morbidity and mortality rates. They are pathogens of global concern with a limited treatment pipeline.
View article: Accuracy of antibacterial indication documentation in an electronic medicines management system
Accuracy of antibacterial indication documentation in an electronic medicines management system Open
Introduction Electronic medicines management (EMM) systems are relatively new in the Australian healthcare system. This tertiary hospital network implemented an EMM in 2018, with mandatory documentation of antimicrobial indication when pre…
View article: Pandora’s box: Paxlovid, prescribing, pharmacists and pandemic
Pandora’s box: Paxlovid, prescribing, pharmacists and pandemic Open
Oral antivirals are a potential ‘game changer’ for healthcare provision during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Whilst various parenteral treatments have been shown to prevent early disease progression – including …
View article: 165. Decreased Antimicrobial Consumption and Decreased Rates of Multi-drug Resistant Organisms Following Onset of the COVID-19 Pandemic: Experience from an Australian Tertiary Hospital
165. Decreased Antimicrobial Consumption and Decreased Rates of Multi-drug Resistant Organisms Following Onset of the COVID-19 Pandemic: Experience from an Australian Tertiary Hospital Open
Background Current guidelines recommend empiric antibiotics be used only for severe cases of coronavirus disease 2019 (COVID-19) or in cases where there is high clinical suspicion for bacterial co-infection. Level of adherence to guideline…
View article: Early antimicrobial stewardship team intervention on appropriateness of antimicrobial therapy in suspected sepsis: a randomized controlled trial
Early antimicrobial stewardship team intervention on appropriateness of antimicrobial therapy in suspected sepsis: a randomized controlled trial Open
Objectives There has been concern that the imperative to administer rapid antimicrobials in septic patients may result in inappropriate antimicrobial use. We aimed to determine the impact of early antimicrobial stewardship (AMS) team inter…
View article: Standard of practice in infectious diseases for pharmacy services
Standard of practice in infectious diseases for pharmacy services Open
Services 1 as the foremost Standard.This Standard may overlap with others and depending on the area of specialty practice it may be advisable to refer to additional Standards of Practice.The use of the ord spe ialisatio i this sta dard is …
View article: The impact of pharmacist‐led antifungal stewardship interventions in the hospital setting: a systematic review
The impact of pharmacist‐led antifungal stewardship interventions in the hospital setting: a systematic review Open
Aim To summarise the evidence on pharmacist‐led antifungal stewardship (AFS) programs in the hospital setting and to evaluate their impact on the quality of antifungal prescribing and infection management, antifungal usage and clinical out…
View article: Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries
Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries Open
Objectives The WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries and hospitals in promoting rational use of antibiotics while improving access to these essential medicines. We aimed to describe pa…
View article: Building on Antimicrobial Stewardship Programs Through Integration with Electronic Medical Records: The Australian Experience
Building on Antimicrobial Stewardship Programs Through Integration with Electronic Medical Records: The Australian Experience Open
Antimicrobial stewardship (AMS) is well established in Australian hospitals. Electronic medical record (EMR) implementation has lagged in Australia, with two Healthcare Information and Management Systems Society (HIMSS) Stage 6 hospitals a…
View article: Global contributions of pharmacists during the <scp>COVID</scp>‐19 pandemic
Global contributions of pharmacists during the <span>COVID</span>‐19 pandemic Open
Throughout the SARS‐CoV‐2 (COVID‐19) global pandemic, pharmacists were rarely mentioned as essential frontline health care providers by the news media, the public, or politicians. Around the world, pharmacists are working on the frontlines…
View article: Ushering in Antifungal Stewardship: Perspectives of the Hematology Multidisciplinary Team Navigating Competing Demands, Constraints, and Uncertainty
Ushering in Antifungal Stewardship: Perspectives of the Hematology Multidisciplinary Team Navigating Competing Demands, Constraints, and Uncertainty Open
Background The social, contextual, and behavioral determinants that influence care in patients at risk for invasive fungal diseases (IFD) are poorly understood. This knowledge gap is a barrier to the implementation of emerging antifungal s…
View article: Root Cause Analysis to Identify Medication and Non-Medication Strategies to Prevent Infection-Related Hospitalizations from Australian Residential Aged Care Services
Root Cause Analysis to Identify Medication and Non-Medication Strategies to Prevent Infection-Related Hospitalizations from Australian Residential Aged Care Services Open
Infections are leading causes of hospitalizations from residential aged care services (RACS), which provide supported accommodation for people with care needs that can no longer be met at home. Preventing infections and early and effective…
View article: A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway
A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway Open
This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agent…
View article: The impact of a multidisciplinary antimicrobial stewardship team on the timeliness of antimicrobial therapy in patients with positive blood cultures: a randomized controlled trial
The impact of a multidisciplinary antimicrobial stewardship team on the timeliness of antimicrobial therapy in patients with positive blood cultures: a randomized controlled trial Open
Antimicrobial stewardship team review of patients with pathogenic positive blood cultures improved the time to both active and appropriate antimicrobial therapy.