Kelly P. Yamada
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View article: A minimally invasive swine model of chronic kidney disease-associated heart failure
A minimally invasive swine model of chronic kidney disease-associated heart failure Open
Cardiac pathological changes consistent with heart failure with preserved ejection fraction can be induced in a large animal model by serial and titrated renal embolization of kidneys with autologous clot, leading to severe renal dysfuncti…
View article: AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine
AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine Open
Adeno-associated virus-based gene therapy is a promising avenue in heart failure treatment, but has shown limited cardiac virus uptake in humans, requiring new approaches for clinical translation. Using a Yorkshire swine ischemic heart fai…
View article: Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis
Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis Open
Aims Vein grafts are used for many indications, including bypass graft surgery and arteriovenous fistula (AVF) formation. However, patency following vein grafting or AVF formation is suboptimal for various reasons, including thrombosis, ne…
View article: Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading
Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading Open
View article: Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion
Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion Open
Limited reports exist regarding adeno-associated virus (AAV) biodistribution in swine. This study assessed biodistribution following antegrade intracoronary and intravenous delivery of two self-complementary serotype 9 AAV (AAV9sc) biologi…
View article: <scp>SUMOylation</scp> does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca<sup>2+</sup>
<span>SUMOylation</span> does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca<sup>2+</sup> Open
Post‐translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin…
View article: Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck
Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck Open
A disappointing number of new therapies for pulmonary hypertension (PH) have been successfully translated to the clinic. Adeno-associated viral (AAV) gene therapy has the potential to treat the underlying pathology of PH, but the challenge…
View article: Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure
Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure Open
Background: Impact of mechanical left ventricular (LV) unloading on myocardial tissue perfusion and its regulating factors remain unclear. This study was conducted to elucidate the predictors of regional blood flow (RBF) improvement by mec…
View article: Corrigendum: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics
Corrigendum: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics Open
[This corrects the article DOI: 10.3389/fcvm.2020.00162.].
View article: Effects of Therapeutic Hypothermia on Normal and Ischemic Heart
Effects of Therapeutic Hypothermia on Normal and Ischemic Heart Open
Therapeutic hypothermia has been used for treating brain injury after out-of-hospital cardiac arrest. Its potential benefit on minimizing myocardial ischemic injury has been explored, but clinical evidence has yet to confirm positive resul…
View article: Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction
Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction Open
Strain analysis was performed in 104 pigs after MI, and its relationship to invasive hemodynamic measurements was studied. Impaired longitudinal strain was associated with high ventricular filling pressure independent of LV EF in post-MI s…
View article: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics
Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics Open
Background: Coronary artery dissection (CAD) sometimes accompanies unstable hemodynamics and requires mechanical cardiac support. Meanwhile, mechanical cardiac support may influence coronary hemodynamics in CAD. No study has examined the i…
View article: Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis
Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis Open
View article: Consideration of clinical translation of cardiac AAV gene therapy
Consideration of clinical translation of cardiac AAV gene therapy Open
Advancements in conventional cardiac care have significantly reduced mortality from coronary heart disease and acute myocardial infarction. However, the prevalence of heart failure continues to increase in an aging population with profound…
View article: Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases
Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases Open
View article: A Novel Large Animal Model of Thrombogenic Coronary Microembolization
A Novel Large Animal Model of Thrombogenic Coronary Microembolization Open
Coronary microembolization is one of the main causes of the “no-reflow” phenomenon, which commonly occurs after reperfusion of an occluded coronary artery. Given its high incidence and the fact that it has been proven to be an independent …