Kelsey A. Heslin
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View article: Automated device for simultaneous photometry and electrophysiology in freely moving animals
Automated device for simultaneous photometry and electrophysiology in freely moving animals Open
Photometry and electrophysiology are powerful tools for investigating brain-behavior relationships. Combining these techniques would allow us to ask previously un-addressable questions, such as how neuromodulators impact neuronal firing ra…
View article: Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice
Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice Open
Short abstract The basolateral amygdala (BLA) projects to the frontal cortex (FC) in both rodents and primates, but the comparative organization of single-neuron BLA-FC projections is unknown. Using a barcoded connectomic approach, we foun…
View article: The dorsal hippocampus’ role in context-based timing in rodents
The dorsal hippocampus’ role in context-based timing in rodents Open
To act proactively, we must predict when future events will occur. Individuals generate temporal predictions using cues that indicate an event will happen after a certain duration elapses. Neural models of timing focus on how the brain rep…
View article: Communication between the mediodorsal thalamus and prelimbic cortex regulates timing performance in rats
Communication between the mediodorsal thalamus and prelimbic cortex regulates timing performance in rats Open
Predicting when future events will occur and adjusting behavior accordingly is critical to adaptive behavior. Despite this, little is known about the brain networks that encode time and how this ultimately impacts decision-making. One esta…
View article: No preference for prosocial ‘helping’ behavior in rats with concurrent social interaction opportunities
No preference for prosocial ‘helping’ behavior in rats with concurrent social interaction opportunities Open
‘Helping behavior’ tasks are proposed to assess prosocial or ‘empathic’ behavior in rodents. This paradigm characterizes the behavior of subject animals presented with the opportunity to release a conspecific from a distressing situation. …
View article: Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice
Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice Open
Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of their specific physiological properties, parvalbumin-expressing (P…
View article: Npas4 deficiency and prenatal stress interact to affect social recognition in mice
Npas4 deficiency and prenatal stress interact to affect social recognition in mice Open
Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proport…