Kelsey Diffley
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View article: Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates
Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates Open
Summary Histone deacetylases play important biological roles well beyond the deacetylation of histone tails. In particular, HDAC6 is involved in multiple cellular processes such as apoptosis, cytoskeleton reorganization, and protein foldin…
View article: Regulation of Activity and Selectivity of Histone Deacetylases
Regulation of Activity and Selectivity of Histone Deacetylases Open
Acetylation is an important post-translational modification (PTM). Lysine acetylation is a reversible PTM, where deacetylation is catalyzed by histone deacetylases (HDACs). Histone deacetylase function is crucial for a correctly functionin…
View article: Amend Pandemic Preparedness Legislation to Prioritize Diagnostic Test Development and Deployment
Amend Pandemic Preparedness Legislation to Prioritize Diagnostic Test Development and Deployment Open
As the world becomes increasingly globalized, the propensity of pandemics, such as COVID-19, increases. The United States Pandemic and All-Hazards Preparedness and Advancing Innovation Act of 2019 (PAHPAI) details the federal response to a…
View article: Flexible, symmetry-directed approach to assembling protein cages
Flexible, symmetry-directed approach to assembling protein cages Open
Significance The ability to organize biological molecules into new hierarchical forms represents an important goal in synthetic biology. However, designing new quaternary interactions between protein subunits has proved technically challen…