Kieran C. Murphy
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View article: Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology
Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology Open
Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.
View article: Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy
Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy Open
Objective Few prospective studies exist on newly diagnosed focal epilepsy (NDFE), a critical period for understanding epilepsy's biology and identifying biomarkers and potential interventions. We report a prospective cohort study in patien…
View article: Impact of nutritional interventions on quality of life in schizophrenia spectrum disorders: a scoping review
Impact of nutritional interventions on quality of life in schizophrenia spectrum disorders: a scoping review Open
Objectives: Schizophrenia is a chronic condition that requires long-term management. Quality of life is an important outcome measure for individuals diagnosed with schizophrenia; it can be tracked over time allowing evaluation of whether i…
View article: Cognitive outcomes and performance of patients diagnosed and treated for N-Methyl-D-Aspartate receptor antibody-mediated (NMDAR) encephalitis compared with patients with schizophrenia and healthy controls
Cognitive outcomes and performance of patients diagnosed and treated for N-Methyl-D-Aspartate receptor antibody-mediated (NMDAR) encephalitis compared with patients with schizophrenia and healthy controls Open
Study findings suggest cognitive performance in patients treated for NMDAR encephalitis approaches normal over time. Prompt treatment with immunotherapy is associated with improved cognitive outcomes. Psychiatric services should be aware o…
View article: Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy
Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy Open
Objective There are few prospective longitudinal studies in patients with newly diagnosed epilepsy (NDE) despite that this is a key time point to understand the underlying biology of epilepsy and to identify potential interventions and bio…
View article: The impact of badmouthing of medical specialities to medical students
The impact of badmouthing of medical specialities to medical students Open
Objectives: This study aimed to evaluate the proportion of Irish medical students exposed to ‘badmouthing’ of different specialities and to ascertain: the degree of criticism of specialities based on the seniority of clinical or academic m…
View article: Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome
Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome Open
22q11.2 deletion syndrome (22q11DS) is the most frequently occurring microdeletion in humans. It is associated with a significant impact on brain structure, including prominent reductions in gray matter volume (GMV), and neuropsychiatric m…
View article: Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease
Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease Open
Background Congenital heart disease (CHD) affecting the conotruncal region of the heart, occur in half of patients with 22q11.2 deletion syndrome. This syndrome is a rare disorder with relative genetic homogeneity that can facilitate ident…
View article: Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families
Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families Open
Multiplex families have higher recurrence risk of schizophrenia compared to the families of sporadic cases, but the source of this increased recurrence risk is unknown. We used schizophrenia genome-wide association study data ( N = 156,509…
View article: Neuropsychiatric manifestations in a patient with prolonged COVID-19 encephalopathy: case report and literature review
Neuropsychiatric manifestations in a patient with prolonged COVID-19 encephalopathy: case report and literature review Open
While the respiratory complications of COVID-19 infection are now well known, psychiatric manifestations are an emerging issue. We report a case of prolonged encephalopathy secondary to COVID-19 which was associated with prominent neuropsy…
View article: DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia Open
We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resis…
View article: Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics
Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics Open
22q11.2 deletion syndrome (22q11DS) results from a hemizygous deletion that typically spans 46 protein-coding genes and is associated with widespread alterations in brain morphology. The specific genetic mechanisms underlying these alterat…
View article: An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis Open
Identifying rare, highly penetrant risk mutations may be an important step in dissecting the molecular etiology of schizophrenia. We conducted a gene-based analysis of large (>100 kb), rare copy-number variants (CNVs) in the Wellcome Trust…
View article: Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome Open
Chromosome 22q11.2 deletion syndrome is a neurogenetic disorder associated with high rates of schizophrenia and other psychiatric conditions. The authors report what is to their knowledge the first large-scale collaborative study of rates …
View article: Impact of initial COVID-19 restrictions on psychiatry presentations to the emergency department of a large academic teaching hospital
Impact of initial COVID-19 restrictions on psychiatry presentations to the emergency department of a large academic teaching hospital Open
Objectives: To determine if the initial COVID-19 societal restrictions, introduced in Ireland in March 2020, impacted on the number and nature of psychiatry presentations to the emergency department (ED) of a large academic teaching hospit…
View article: Undergraduate learning in psychiatry: can we prepare our future medical graduates better?
Undergraduate learning in psychiatry: can we prepare our future medical graduates better? Open
Irish medical schools attract an increasingly diverse student population and produce graduates who will practise in many parts of the world. There are particular implications in this for the planning and delivery of the undergraduate psych…
View article: Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia
Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia Open
Objective Psychosis - a complex and heterogeneous neuropsychiatric condition characterized by hallucinations and delusions - is a common feature of schizophrenia. There is evidence for altered DNA methylation (DNAm) associated with schizop…
View article: Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness
Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness Open
In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness. Findings indicate significant overlap between 22q11…
View article: 247 Antipsychotic Medication in the Management of Non-cognitive Symptoms of Dementia: An Updated Evidence Review
247 Antipsychotic Medication in the Management of Non-cognitive Symptoms of Dementia: An Updated Evidence Review Open
Background Antipsychotic medications are commonly used in the management of non-cognitive symptoms of dementia (also termed behavioural and psychological symptoms of dementia), such as agitation, calling out, hoarding, or aggression. This …
View article: Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study
Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study Open
22q11.2 deletion syndrome (22q11DS)—a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22—is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magne…
View article: Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review
Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review Open
The relationship between serum prolactin and bone mineral density (BMD) in schizophrenia is unclear. We conducted a literature review of databases from inception until December 2018 for cross-sectional, case-control, prospective and retros…
View article: Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects
Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects Open
The 22q11.2 deletion syndrome is caused by non‐allelic homologous recombination events during meiosis between low copy repeats (LCR22) termed A, B, C, and D. Most patients have a typical LCR22A‐D (AD) deletion of 3 million base pairs (Mb).…
View article: Hepatitis, Interstitial Nephritis, and Pancreatitis in Association With Clozapine Treatment
Hepatitis, Interstitial Nephritis, and Pancreatitis in Association With Clozapine Treatment Open
Purpose/Background Clozapine is the criterion standard in treatment-resistant schizophrenia. We sought to review data on several inflammatory effects associated with clozapine, specifically interstitial nephritis, hepatitis, and pancreatit…