Kelvin W. Li
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View article: Metabolic labeling kinetics of brain-derived 24S-hydroxycholesterol in blood in multiple sclerosis: Effects of treatment with the remyelinating antibody rHIgM22
Metabolic labeling kinetics of brain-derived 24S-hydroxycholesterol in blood in multiple sclerosis: Effects of treatment with the remyelinating antibody rHIgM22 Open
Background Cholesterol is an essential and major component of myelin. Brain cholesterol turnover in humans can be studied noninvasively by metabolic labeling of the brain-specific cholesterol metabolite, 24S-hydroxycholesterol (24-OHC), wh…
View article: Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate
Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate Open
Treatment with acetyl-CoA carboxylase inhibitors (ACCi) in nonalcoholic steatohepatitis (NASH) may increase plasma triglycerides (TGs), with variable changes in apoB concentrations. ACC is rate limiting in de novo lipogenesis and regulates…
View article: Selective decrease of donor-reactive T <sub>regs</sub> after liver transplantation limits T <sub>reg</sub> therapy for promoting allograft tolerance in humans
Selective decrease of donor-reactive T <sub>regs</sub> after liver transplantation limits T <sub>reg</sub> therapy for promoting allograft tolerance in humans Open
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and morbidity. Regulatory T cells (T regs ) are essential for immune tole…
View article: Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients
Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients Open
View article: Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease
Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease Open
BACKGROUNDHepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver disease (NAFLD). Improvements in hepatic fat by dietary sugar reduction may be mediated by reduced DNL, but data are limited, especially in children. We ex…
View article: Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination
Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination Open
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful…
View article: Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy Open
During gestation, the female reproductive tract must maintain pregnancy while concurrently preparing for parturition. Here, we explore the transitions in gene expression and protein turnover (fractional synthesis rates [FSR]) by which the …
View article: Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination
Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination Open
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful…
View article: Dynamics of hepatic steatosis resolution and changes in gut microbiome with weight loss in nonalcoholic fatty liver disease
Dynamics of hepatic steatosis resolution and changes in gut microbiome with weight loss in nonalcoholic fatty liver disease Open
Background Weight loss is recommended as the primary treatment for nonalcoholic fatty liver disease (NAFLD). However, the magnitude and velocity of hepatic steatosis resolution with weight loss is unclear, making it difficult to counsel pa…
View article: Inhibition of fatty acid synthase with <scp>FT‐4101</scp> safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two early‐phase randomized trials
Inhibition of fatty acid synthase with <span>FT‐4101</span> safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two early‐phase randomized trials Open
Aims To assess the therapeutic potential of fatty acid synthase (FASN) inhibition with FT‐4101, a potent, selective, orally bioavailable, small‐molecule by (a) evaluating the dose−response of single FT‐4101 doses (3, 6 and 9 mg) on hepatic…
View article: Author response for "Inhibition of fatty acid synthase with <scp>FT</scp> ‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with <scp>NAFLD</scp> non‐alcoholic fatty liver disease: results from two early phase randomized trials"
Author response for "Inhibition of fatty acid synthase with <span>FT</span> ‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with <span>NAFLD</span> non‐alcoholic fatty liver disease: results from two early phase randomized trials" Open
Aims To assess the therapeutic potential of fatty acid synthase (FASN) inhibition with FT-4101, a potent, selective, orally bioavailable, small-molecule by (a) evaluating the dose-response of single FT-4101 doses (3, 6 and 9 mg) on hepatic…
View article: Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction
Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction Open
Key points Strategies to enhance the loss of fat while preserving muscle mass during energy restriction are of great importance to prevent sarcopenia in overweight older adults. We show for the first time that the integrated rate of synthe…
View article: Origin and differentiation of human memory CD8 T cells after vaccination
Origin and differentiation of human memory CD8 T cells after vaccination Open
View article: Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model Open
View article: Imaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry
Imaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry Open
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabo…
View article: Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib
Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib Open
BACKGROUND. Ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL) that inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. METHODS. We used stable…
View article: Desorption Electrospray Ionization (DESI) Mass Spectrometric Imaging of Spatially Regulated In Vivo Metabolic Rates
Desorption Electrospray Ionization (DESI) Mass Spectrometric Imaging of Spatially Regulated In Vivo Metabolic Rates Open
Desorption electrospray ionization (DESI) is an ambient ionization technique used for mass spectrometric imaging of biological samples. When coupled with isotopic ratio measurements of deuterium-labeled tissues, DESI provides a means of me…
View article: Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood
Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood Open
Using a well-characterized cohort of patients with biopsy-proven NAFLD, this study demonstrates that hepatic scar in NASH is actively remodeled even in advanced fibrosis, a disease that is generally regarded as static and slowly progressiv…
View article: Circulating protein synthesis rates reveal skeletal muscle proteome dynamics
Circulating protein synthesis rates reveal skeletal muscle proteome dynamics Open
Here, we have described and validated a strategy for monitoring skeletal muscle protein synthesis rates in rodents and humans over days or weeks from blood samples. We based this approach on label incorporation into proteins that are synth…
View article: Turnover Rates of Hepatic Collagen and Circulating Collagen-Associated Proteins in Humans with Chronic Liver Disease
Turnover Rates of Hepatic Collagen and Circulating Collagen-Associated Proteins in Humans with Chronic Liver Disease Open
Accumulation and degradation of scar tissue in fibrotic liver disease occur slowly, typically over many years. Direct measurement of fibrogenesis, the rate of scar tissue deposition, may provide valuable therapeutic and prognostic informat…