Keming Gao
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View article: Nimotuzumab Plus Concurrent Chemoradiotherapy for Locally Advanced Cervical Squamous Cell Carcinoma: Updated Follow-up from the Randomized, Phase 3 CC3 Study
Nimotuzumab Plus Concurrent Chemoradiotherapy for Locally Advanced Cervical Squamous Cell Carcinoma: Updated Follow-up from the Randomized, Phase 3 CC3 Study Open
View article: A Randomized, Placebo-Controlled Pilot Study of Quetiapine-XR Monotherapy or Adjunctive Therapy to Antidepressant in Acute Major Depressive Disorder with Current Generalized Anxiety Disorder
A Randomized, Placebo-Controlled Pilot Study of Quetiapine-XR Monotherapy or Adjunctive Therapy to Antidepressant in Acute Major Depressive Disorder with Current Generalized Anxiety Disorder Open
Objectives To pilot efficacy and safety data of quetiapine-XR monotherapy or adjunctive therapy to antidepressant(s) in the acute treatment of MDD with current generalized anxiety disorder (GAD). Methods The Mini International Neuropsychia…
View article: Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity
Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity Open
Objectives: To sequentially study the effectiveness of lithium and divalproex monotherapy and adjunctive therapy with quetiapine or lamotrigine in the acute and continuation treatment of bipolar I or II disorder at any phase of illness and…
View article: Protein Biomarkers in Monocytes and CD4+ Lymphocytes for Predicting Lithium Treatment Response of Bipolar Disorder: a Feasibility Study with Tyramine-Based Signal- Amplified Flow Cytometry
Protein Biomarkers in Monocytes and CD4+ Lymphocytes for Predicting Lithium Treatment Response of Bipolar Disorder: a Feasibility Study with Tyramine-Based Signal- Amplified Flow Cytometry Open
Purpose To determine if enhanced flow cytometry ( CellPrint™ ) can identify intracellular proteins of lithium responsiveness in monocytes and CD4 + lymphocytes from patients with bipolar disorder. Methods Eligible bipolar I or II patients …
View article: Systematic review on the treatment of emotional abuse victimization in women by an intimate partner
Systematic review on the treatment of emotional abuse victimization in women by an intimate partner Open
Purpose Emotional partner abuse, often closely intertwined with physical assault, involves persistent emotional mistreatment by an intimate partner. Despite its significance, research specifically focusing on emotional IPV is limited. This…
View article: Pharmacological Monotherapy for Depressive Disorders: Current and Future—A Narrative Review
Pharmacological Monotherapy for Depressive Disorders: Current and Future—A Narrative Review Open
Objective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depressive disorders. Methods: Selective serotonin reuptake inhibitors (SSRIs), serotonin norepin…
View article: Oral health and nutrition: addressing disparities in socioeconomically disadvantaged older adults in rural China
Oral health and nutrition: addressing disparities in socioeconomically disadvantaged older adults in rural China Open
This study highlights the critical relationship between oral health, dietary quality and nutritional status among socioeconomically disadvantaged older adults in rural China. The findings underscore the need for targeted interventions to i…
View article: A Pilot Study of Remote Ischemic Conditioning in Preventing Post-Stroke Depression
A Pilot Study of Remote Ischemic Conditioning in Preventing Post-Stroke Depression Open
The study's outcomes indicate that RIC is safe, well-tolerated, and feasible as a preventive measure for PSD. Consequently, it is advisable to conduct a comprehensive randomized controlled trial to further evaluate the effectiveness and sa…
View article: Online Pseudo-average Shifting Attention(PASA) for Robust Low-precision LLM Inference: Algorithms and Numerical Analysis
Online Pseudo-average Shifting Attention(PASA) for Robust Low-precision LLM Inference: Algorithms and Numerical Analysis Open
Attention calculation is extremely time-consuming for long-sequence inference tasks, such as text or image/video generation, in large models. To accelerate this process, we developed a low-precision, mathematically-equivalent algorithm cal…
View article: Quantitative EEG reactivity induced by electrical stimulation predicts good outcome in comatose patients after cardiac arrest
Quantitative EEG reactivity induced by electrical stimulation predicts good outcome in comatose patients after cardiac arrest Open
Background EEG reactivity is a predictor for neurological outcome in comatose patients after cardiac arrest (CA); however, its application is limited by variability in stimulus types and visual assessment. We aimed to evaluate the prognost…
View article: Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report
Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report Open
Background and Objectives: Options for treatment-resistant bipolar depression (TRBPD) are limited. Electroconvulsive therapy (ECT) has shown efficacy in TRBPD. However, the cognitive deficits and memory concerns associated with ECT are pro…
View article: Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder
Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder Open
Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown. Aims To inve…
View article: Possible Role of Correlation Coefficients and Network Analysis of Multiple Intracellular Proteins in Blood Cells of Patients with Bipolar Disorder in Studying the Mechanism of Lithium Responsiveness: A Proof-Concept Study
Possible Role of Correlation Coefficients and Network Analysis of Multiple Intracellular Proteins in Blood Cells of Patients with Bipolar Disorder in Studying the Mechanism of Lithium Responsiveness: A Proof-Concept Study Open
Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD) remains unclear. The aim of this study was to explore the utility of correlation coefficients and protein-to-protein interaction (PPI) network analyses …
View article: Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials
Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials Open
Background: This meta-analysis aimed to determine the efficacy and safety of antidiabetic agents in the treatment of major depressive disorder and bipolar depression. Methods: Randomized controlled trials (RCTs) of antidiabetic agents in m…
View article: Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study
Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study Open
practical treatment implications for TRD.
View article: Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions
Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions Open
Deep brain regions such as hippocampus, insula, and amygdala are involved in neuropsychiatric disorders, including chronic insomnia and depression. Our recent reports showed that transcranial alternating current stimulation (tACS) with a c…
View article: Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis Open
View article: Differences in intracellular protein levels in monocytes and CD4+ lymphocytes between bipolar depressed patients and healthy controls: A pilot study with tyramine-based signal-amplified flow cytometry
Differences in intracellular protein levels in monocytes and CD4+ lymphocytes between bipolar depressed patients and healthy controls: A pilot study with tyramine-based signal-amplified flow cytometry Open
View article: Divergent Directionality of Immune Cell-Specific Protein Expression between Bipolar Lithium Responders and Non-Responders Revealed by Enhanced Flow Cytometry
Divergent Directionality of Immune Cell-Specific Protein Expression between Bipolar Lithium Responders and Non-Responders Revealed by Enhanced Flow Cytometry Open
Background and Objectives: There is no biomarker to predict lithium response. This study used CellPrint™ enhanced flow cytometry to study 28 proteins representing a spectrum of cellular pathways in monocytes and CD4+ lymphocytes before and…
View article: Comprehensive Analysis of Electronic Health Records to Characterize The Association Between Intimate Partner Violence and Mental Health.
Comprehensive Analysis of Electronic Health Records to Characterize The Association Between Intimate Partner Violence and Mental Health. Open
Intimate partner violence (IPV) involves physical, emotional, and sexual harm to the survivor. To characterize the relationship between mental health and IPV, we utilized electronic health records (EHR) data from IBM Explorys. Focusing on …
View article: Association Between Race and Irritability, Inflammation, and Depression During Chemotherapy
Association Between Race and Irritability, Inflammation, and Depression During Chemotherapy Open
Objectives: This study aimed to assess whether race modifies irritability and immunological inflammation, and their interaction to worsen depression during chemotherapy. Methods: 25 African American and 19 White nonmetastasized breast canc…
View article: Network-based integrative analysis of lithium response in bipolar disorder using transcriptomic and GWAS data
Network-based integrative analysis of lithium response in bipolar disorder using transcriptomic and GWAS data Open
Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distingu…
View article: Correction of depression‐associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder
Correction of depression‐associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder Open
Background Bipolar disorder (BD) is characterized by episodes of depression and mania and disrupted circadian rhythms. Lithium is an effective therapy for BD, but only 30%–40% of patients are fully responsive. Preclinical models show that …
View article: Transcranial alternating current stimulation for treating depression: a randomized controlled trial
Transcranial alternating current stimulation for treating depression: a randomized controlled trial Open
Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients with major depressive disorder. However, no study has used the …
View article: Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome
Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome Open
View article: Clinical predictors of non‐response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study
Clinical predictors of non‐response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study Open
Background Lithium is regarded as a first‐line treatment for bipolar disorder (BD), but partial response and non‐response commonly occurs. There exists a need to identify lithium non‐responders prior to initiating treatment. The Pharmacoge…
View article: Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A meta-analysis of randomized, double-blind, placebo-controlled trials
Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A meta-analysis of randomized, double-blind, placebo-controlled trials Open
e c t i v e : To systematically evaluate the efficacy and safety of hypoglycemic agents for the treatment of a depressive episode of major depressive or bipolar disorder.Condition being studied: Major depressive disorder and bipolar depres…
View article: Safety and Tolerability of Both Arm Ischemic Conditioning in Patients With Major Depression: A Proof of Concept Study
Safety and Tolerability of Both Arm Ischemic Conditioning in Patients With Major Depression: A Proof of Concept Study Open
RLIPC was safe and well tolerated, and may be effective in reducing depressive symptoms in patients with MDD. Large studies are warranted to test its efficacy and safety as monotherapy or adjunctive therapy in the treatment of MDD.
View article: Brainstorming Session I‐Actigraphy in bipolar disorders: Which parameters and which analyses? Chair: Benicio Frey
Brainstorming Session I‐Actigraphy in bipolar disorders: Which parameters and which analyses? Chair: Benicio Frey Open
Through the use of actigraphy, sleep-wake cycle and biological rhythm patterns have been increasingly investigated in mood disorders, such as bipolar disorders (BD).Increasingly, attention has been directed toward studying actigraphy-deriv…
View article: The association between lithium use and neurocognitive performance in patients with bipolar disorder
The association between lithium use and neurocognitive performance in patients with bipolar disorder Open