Ken Iseri
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View article: Association between CKD-MBD and hip-bone microstructures in dialysis patients
Association between CKD-MBD and hip-bone microstructures in dialysis patients Open
Background The longitudinal changes in hip-bone microstructures and estimated bone strength in dialysis patients, and the impact of chronic kidney disease–mineral and bone disorder (CKD-MBD) biomarkers on these changes, remain insufficient…
View article: Fibrates and the risk of cardiovascular outcomes in chronic kidney disease patients
Fibrates and the risk of cardiovascular outcomes in chronic kidney disease patients Open
Background The high risk of major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD) has been well described. However, the efficacy of fibrates on the risk of MACE in patients with CKD remains unclear. Metho…
View article: Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing
Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing Open
Background Chronic kidney disease (CKD) is an age‐related disease that displays multiple features of accelerated ageing. It is currently unclear whether the two treatment options for end‐stage kidney disease (dialysis and kidney transplant…
View article: Long-Term Effect of Denosumab on Bone Disease in Patients with CKD
Long-Term Effect of Denosumab on Bone Disease in Patients with CKD Open
Background The effect of long-term denosumab therapy and of denosumab discontinuation on the cortical bone of the hip regions in dialysis patients has not been studied. Methods This retrospective study investigated the cortical and trabecu…
View article: Risk factors for blood vessel rupture during vascular access intervention therapy for hemodialysis patients
Risk factors for blood vessel rupture during vascular access intervention therapy for hemodialysis patients Open
Blood vessel rupture is a major complication associated with vascular access intervention therapy (VAIVT). However, information regarding the risk factors for ruptures related to VAIVT is limited. The purpose of this study was to investiga…
View article: Secular trends in incidence and seasonal variation of distal radius fracture among children: A nationwide study based on the Swedish National Patient Register 2002–2016
Secular trends in incidence and seasonal variation of distal radius fracture among children: A nationwide study based on the Swedish National Patient Register 2002–2016 Open
We found significant seasonal variation in DRF among all age groups in Swedish children. The findings can help in developing strategies to prevent fractures as well as in allocating medical and social resources.
View article: Short-term impact of switching from erythropoiesis-stimulating agents and roxadustat to daprodustat among patients undergoing hemodialysis
Short-term impact of switching from erythropoiesis-stimulating agents and roxadustat to daprodustat among patients undergoing hemodialysis Open
Daprodustat is a novel oral agent for renal anemia. This retrospective study examined 124 maintenance patients undergoing HD who had shifted from erythropoiesis-stimulating agents (ESA) or roxadustat to daprodustat (4mg daily). Anemia cont…
View article: Secular trends in hip fracture incidence and subsequent mortality in dialysis patients and the general population in Sweden
Secular trends in hip fracture incidence and subsequent mortality in dialysis patients and the general population in Sweden Open
Hip fracture incidence and subsequent mortality fell among women and men in the Swedish general population. In dialysis patients, hip fracture incidence declined in women but not in men while post-fracture mortality did not improve, and th…
View article: Incidence of Fractures Before and After Dialysis Initiation
Incidence of Fractures Before and After Dialysis Initiation Open
Fractures are common in dialysis patients, but little is known about the trajectory of incidence rates of different types of fractures before and after dialysis initiation. To address this, we investigated the incidence of major fractures …
View article: Fractures after kidney transplantation: Incidence, predictors, and association with mortality
Fractures after kidney transplantation: Incidence, predictors, and association with mortality Open
The initial 6 months following kidney transplantation is a high-risk period for MF. Among MF, hip fracture and spine fracture associate with substantially increased all-cause mortality risk.
View article: P1389MAJOR OSTEOPOROTIC FRACTURES AFTER INITIATION OF DIALYSIS: INCIDENCE, PREDICTORS AND ASSOCIATION WITH MORTALITY
P1389MAJOR OSTEOPOROTIC FRACTURES AFTER INITIATION OF DIALYSIS: INCIDENCE, PREDICTORS AND ASSOCIATION WITH MORTALITY Open
Background and Aims Major osteoporotic fractures (MOF) are common in dialysis patients. We investigated incidence, predictors and clinical outcomes associated with first MOF occurring after initiation of dialysis (MOFfirst). Method In Swed…
View article: P1409HIP FRACTURE TRENDS IN SWEDISH GENERAL POPULATION AND DIALYSIS PATIENTS
P1409HIP FRACTURE TRENDS IN SWEDISH GENERAL POPULATION AND DIALYSIS PATIENTS Open
Background and Aims Hip fracture incidence rate is higher in dialysis patients than in general population. We investigated and compared temporal changes in age-standardized hip fracture incidence rate (ASRhip fracture) 2007-2016 in men and…
View article: P0669HIGH ESTIMATED PHENOTYPIC AGE ASSOCIATES WITH WORSE CLINICAL OUTCOME IN CHRONIC KIDNEY DISEASE PATIENTS
P0669HIGH ESTIMATED PHENOTYPIC AGE ASSOCIATES WITH WORSE CLINICAL OUTCOME IN CHRONIC KIDNEY DISEASE PATIENTS Open
Background and Aims Ageing represents the greatest risk factor contributing to increased morbidity and mortality in most chronic diseases; it encompasses numerous biological changes resulting in declining physiological function and increas…
View article: P0714RELATIONSHIP BETWEEN BIOLOGICAL AGE ESTIMATED BY SKIN AUTOFLUORESCENCE, CHRONOLOGICAL AGE, AND MORTALITY IN CHRONIC KIDNEY DISEASE
P0714RELATIONSHIP BETWEEN BIOLOGICAL AGE ESTIMATED BY SKIN AUTOFLUORESCENCE, CHRONOLOGICAL AGE, AND MORTALITY IN CHRONIC KIDNEY DISEASE Open
Background and Aims While chronological age associates with increased risk of death, there is a quest for markers of biological age in chronic kidney disease (CKD) that better reflect accumulation of tissue and cellular damage, which could…
View article: Bone mineral density and mortality in end-stage renal disease patients
Bone mineral density and mortality in end-stage renal disease patients Open
Osteoporosis characterized by low bone mineral density (BMD) as assessed by dual-energy X-ray absorptiometry (DXA) is common among end-stage renal disease (ESRD) patients and associates with high fracture incidence and high all-cause morta…
View article: Inverse association of transferrin saturation with mortality risk in chronic kidney disease
Inverse association of transferrin saturation with mortality risk in chronic kidney disease Open
Background: Transferrin saturation (TSAT) is an indicator of iron deficiency or overload, but its relationship with mortality in patients with different stages of chronic kidney disease (CKD) is unclear. We investigated the association of …
View article: Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats
Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats Open
Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan. The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmo…
View article: FC020BONE MINERAL DENSITY AT VARIOUS SITES VERSUS MORTALITY IN END-STAGE RENAL DISEASE (ESRD)
FC020BONE MINERAL DENSITY AT VARIOUS SITES VERSUS MORTALITY IN END-STAGE RENAL DISEASE (ESRD) Open
INTRODUCTION:Osteoporosis is a major problem in ESRD patients that contributes to increased morbimortality and leads to high costs due to complications such as fractures.We assessed bone mineral density (BMD) at various bone sites and anal…
View article: Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy
Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy Open
Although IgAN and HSPN remain difficult to differentiate, s-Gd-IgA1 elevation and m-Gd-IgA1 deposition are reliable diagnostic factors that reflect IgAN severity. Serum-Gd-IgA1 could serve as a predictor of renal outcomes in IgAN. Thus, Gd…
View article: The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial
The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial Open
In patients with GIOP, denosumab treatment markedly suppressed bone turnover, which led to a significantly greater increase in LS BMD than with alendronate treatment. These results suggest that denosumab is a therapeutic option for the tre…
View article: Transactions of The Showa University Society : The 349<sup>th</sup> Meeting
Transactions of The Showa University Society : The 349<sup>th</sup> Meeting Open
Aspergillus fumigatus (Af) is a ubiquitous fungus in our environment that causes severe airway disorders.Chronic respiratory diseases (CRDs) comprise various upper and lower respiratory disorders ranging from asthma, chronic obstructive pu…
View article: Erlotinib attenuates the progression of chronic kidney disease in rats with remnant kidney
Erlotinib attenuates the progression of chronic kidney disease in rats with remnant kidney Open
EGFR blocking by erlotinib protected against renal fibrosis in 5/6 nephrectomized rats via inhibition of Akt and ERK 1/2 signaling pathways, which are associated with renal fibrosis. Erlotinib also has anti-inflammatory properties, which m…