Ken Uekawa
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View article: Histopathological evaluation of dopamine receptor D2 expression in symptomatic gonadotroph pituitary neuroendocrine tumors: a case series including a rare metastatic case responsive to a dopamine agonist
Histopathological evaluation of dopamine receptor D2 expression in symptomatic gonadotroph pituitary neuroendocrine tumors: a case series including a rare metastatic case responsive to a dopamine agonist Open
Functioning gonadotroph pituitary neuroendocrine tumors (Gn-PitNETs) cause ovarian hyperstimulation. We report Gn-PitNETs, including a distant metastasis case responsive to a dopamine agonist (DA), cabergoline. A 10-year-old girl presented…
View article: The Role and Reliability of Unruptured Intracranial Aneurysm Treatment Score in Decision-making in Surgical Indications for Unruptured Intracranial Aneurysms Based on the Results at a Japanese Single Center
The Role and Reliability of Unruptured Intracranial Aneurysm Treatment Score in Decision-making in Surgical Indications for Unruptured Intracranial Aneurysms Based on the Results at a Japanese Single Center Open
To clarify the role and reliability of unruptured intracranial aneurysm treatment score in the treatment indications of unruptured intracranial aneurysm for Japanese patients, we performed a retrospective comparative analysis of our actual…
View article: Postoperative Solitary Brain Metastasis from Residual Gastric Cancer: A Rare Case Report
Postoperative Solitary Brain Metastasis from Residual Gastric Cancer: A Rare Case Report Open
We experienced an extremely rare case of a solitary brain metastasis after residual gastric cancer surgery. Our findings suggest that aggressive local treatments for brain metastasis, including surgical resection and radiotherapy, may cont…
View article: Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion
Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion Open
Objective Indirect bypass using autologous tissue is effective in Moyamoya disease, especially inpediatric patients. The aim of this study was to evaluate the effectiveness of indirect bypass using DuraGen, an absorbable artificial dura ma…
View article: tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice
tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice Open
INTRODUCTION Amyloid beta (Aβ) impairs the cerebral blood flow (CBF) increase induced by neural activity (functional hyperemia). Tissue plasminogen activator (tPA) is required for functional hyperemia, and in mouse models of Aβ accumulatio…
View article: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress Open
Background Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated i…
View article: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress Open
Background: Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated …
View article: Two children with lymphocytic hypophysitis presenting with positive anti-rabphilin-3A antibody
Two children with lymphocytic hypophysitis presenting with positive anti-rabphilin-3A antibody Open
Lymphocytic hypophysitis (LYH) is a rare chronic inflammatory disease characterized by lymphocytic infiltration of the anterior or posterior pituitary gland and hypothalamus. LYH is subdivided into lymphocytic adenohypophysitis (LAH), lymp…
View article: BT-5 LONG-TERM OUTCOME OF CLIVAL CHORDOMAS AT A SINGLE INSTITUTION
BT-5 LONG-TERM OUTCOME OF CLIVAL CHORDOMAS AT A SINGLE INSTITUTION Open
Purpose Chordoma is a rare malignant tumor, about 30% of which occurs in the clivus. The purpose of this study is to investigate the outcome after treatment of clival chordoma in our institute. Methods Nineteen patients {M/F=11/8, mean age…
View article: IM-8 Significance of IL-1 pathways in Glioblastoma
IM-8 Significance of IL-1 pathways in Glioblastoma Open
Purpose: Previous studies have revealed that macrophages affect the prognosis of glioblastoma. However, there are still many unknown parts about the mechanism. In this study, we conducted an experiment with the aim of elucidating the mecha…
View article: Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway
Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway Open
Glioblastoma is a glioma characterized by highly malignant features. Numerous studies conducted on the relationship between glioblastoma and the microenvironment have indicated the significance of tumor-associated macrophages/microglia (TA…
View article: Artificial Intelligence Trained by Deep Learning Can Improve Computed Tomography Diagnosis of Nontraumatic Subarachnoid Hemorrhage by Nonspecialists
Artificial Intelligence Trained by Deep Learning Can Improve Computed Tomography Diagnosis of Nontraumatic Subarachnoid Hemorrhage by Nonspecialists Open
Subarachnoid hemorrhage (SAH) is a serious cerebrovascular disease with a high mortality rate and is known as a disease that is hard to diagnose because it may be overlooked by noncontrast computed tomography (NCCT) examinations that are m…
View article: A ruptured aneurysm arising from the total duplication of the posterior communicating artery
A ruptured aneurysm arising from the total duplication of the posterior communicating artery Open
A 36-year-old male suffered from a sudden headache. Computed tomography (CT) showed a subarachnoid hemorrhage (SAH). CT angiography demonstrated an aneurysm arising from the duplicate origin of the right posterior communicating artery (Pco…
View article: Intracranial and extracranial multiple arterial dissecting aneurysms in rheumatoid arthritis: A case report
Intracranial and extracranial multiple arterial dissecting aneurysms in rheumatoid arthritis: A case report Open
Objective We describe a case of intracranial and extracranial multiple arterial dissecting aneurysms in rheumatoid arthritis (RA). Case Presentation A 29-year-old man with a medical history of RA since 18 years of age was admitted to our h…
View article: AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke Open
Post-transcriptional regulation by microRNAs (miRNAs) is essential for complex molecular responses to physiological insult and disease. Although many disease-associated miRNAs are known, their global targets and culminating network effects…
View article: AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis after ischemic stroke
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis after ischemic stroke Open
Post-transcriptional regulation by miRNAs is essential for complex molecular responses to physiological insult and disease. Although many disease-associated miRNAs are known, their global targets and culminating network effects on pathophy…
View article: Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides Open
Rationale: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic factor in Alzheimer dise…
View article: Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice
Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice Open
Hypercapnia induces potent vasodilation in the cerebral circulation. Although it has long been known that prostanoids participate in the cerebrovascular effects of hypercapnia, the role of prostaglandin E2 (PGE2) and PGE2 receptors have no…