Kendall Blumer
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An active Transverse Energy Filter based on microstructured Si-PIN diodes with an angular-selective detection efficiency Open
Si-PIN detectors can be microstructured to achieve angular-selective particle detection capabilities, which we call active Transverse Energy Filter (aTEF). The microstructuring consists of a honeycomb structure of deep hexagonally-shaped h…
Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations Open
Mutant constitutively active (CA) G protein α-subunits encoded by GNAQ or GNA11 (CA-GNAQ/11) drive uveal melanoma (UM), occur in uncommon subtypes of other cancers, and cause Sturge-Weber syndrome and other capillary malformations. CA-GNAQ…
Examination of INPP5A in uveal melanoma uncovers novel calcium transients Open
Uveal melanoma is a highly aggressive intraocular cancer that metastasizes in about half of patients whereupon it is inexorably fatal. Uveal melanomas (UM) are distinct from other melanomas because they are driven by constitutively activat…
View article: Stabilization of interdomain closure by a G protein inhibitor
Stabilization of interdomain closure by a G protein inhibitor Open
Inhibitors of heterotrimeric G proteins are being developed as therapeutic agents. Epitomizing this approach are YM-254890 (YM) and FR900359 (FR), which are efficacious in models of thrombosis, hypertension, obesity, asthma, uveal melanoma…
View article: G Protein Activation Occurs via a Largely Universal Mechanism
G Protein Activation Occurs via a Largely Universal Mechanism Open
Understanding how signaling proteins like G proteins are allosterically activated is a long-standing challenge with significant biological and medical implications. Because it is difficult to directly observe such dynamic processes, much o…
View article: G protein activation occurs via a largely universal mechanism
G protein activation occurs via a largely universal mechanism Open
Understanding how signaling proteins like G proteins are allosterically activated is a long-standing challenge with significant biological and medical implications. Because it is difficult to directly observe such dynamic processes, much o…
Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses Open
Metastatic uveal melanoma (UM) patients typically survive only 2 to 3 years because effective therapy does not yet exist. Here, to facilitate the discovery of therapeutic targets in UM, we have identified protein kinase signaling mechanism…
A Building Block Approach for the Total Synthesis of YM‐385781 Open
YM‐254890 and FR900359 are potent and selective inhibitors of the Gq/11‐signaling pathway. As such, they have been attractive targets for both synthesis and biological studies. Yet in spite of this effort, a versatile synthetic approach to…
Figure S5 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Bioluminescent images of hepatic tumors
Data from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Purpose:Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or i…
Supplementary Methods from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Supplementary Materials and Methods
Supplementary Methods from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Supplementary Materials and Methods
Figure S6 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Trametinib in combination with macropinocytosis or mitophagy inhibition
Figure S4 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Validation of hepatic tumor model
Figure S8 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
YAP requirement in MP41 cells
Data from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Purpose:Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or i…
Figure S6 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Trametinib in combination with macropinocytosis or mitophagy inhibition
Figure S3 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Response of uveal melanoma cell lines to MEK1/2 inhibition
Figure S7 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
YAP activation in OMM1 cells
Figure S4 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Validation of hepatic tumor model
Figure S7 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
YAP activation in OMM1 cells
Figure S3 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Response of uveal melanoma cell lines to MEK1/2 inhibition
Figure S8 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
YAP requirement in MP41 cells
Figure S2 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Immunofluorescence analysis of autophagy in OMM2.5 cells with or without trametinib
Figure S2 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Immunofluorescence analysis of autophagy in OMM2.5 cells with or without trametinib
Figure S5 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Bioluminescent images of hepatic tumors
Figure S1 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Galpha and MEK1/2 inhibition in combination with Baf A1 and CQ in MP41 cells
Figure S1 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition Open
Galpha and MEK1/2 inhibition in combination with Baf A1 and CQ in MP41 cells