Kendra N. Wright
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View article: Chymase Activity in Plasma and Urine Extracellular Vesicles in Primary Hypertension
Chymase Activity in Plasma and Urine Extracellular Vesicles in Primary Hypertension Open
Key Points Blood and urine extracellular vesicles isolated from hypertensive patients possess high chymase enzymatic activity. Chymase activity was significantly higher in small extracellular vesicles obtained from hypertensive patients wi…
View article: Chymase in Plasma and Urine Extracellular Vesicles: Novel Biomarkers for Primary Hypertension
Chymase in Plasma and Urine Extracellular Vesicles: Novel Biomarkers for Primary Hypertension Open
BACKGROUND Extracellular vesicles (EVs) have emerged as a promising liquid biopsy for various diseases. For the first time, using plasma and urinary EVs, we assessed the activity of renin-angiotensin system (RAS), a central regulator of re…
View article: Internalization of Angiotensin-(1–12) in Adult Retinal Pigment Epithelial-19 Cells
Internalization of Angiotensin-(1–12) in Adult Retinal Pigment Epithelial-19 Cells Open
Purpose: Angiotensin-(1-12) [Ang-(1-12)] serves as a primary substrate to generate angiotensin II (Ang II) by angiotensin-converting enzyme and/or chymase suggests it may be an unrecognized source of Ang II-mediated microvascular complicat…
View article: Angiotensin (1–12) in Humans With Normal Blood Pressure and Primary Hypertension
Angiotensin (1–12) in Humans With Normal Blood Pressure and Primary Hypertension Open
The importance of canonical versus noncanonical mechanisms for the generation of angiotensins remains a major challenge that, in part, is heavily swayed by the relative efficacy of therapies designed to inhibit renin, ACE (angiotensin-conv…
View article: Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases
Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases Open
The data presented here are related to the research article entitled "Differential expression of the angiotensin-(1-12) [Ang-(1-12)]/chymase axis in human atrial tissue [1]. We have showed that chymase gene transcripts, chymase activity, a…
View article: Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells
Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells Open
Bone marrow (BM) Ang II (angiotensin II) is a major participant in the regulation of hematopoiesis and immunity. The novel tissue substrate Ang-(1–12) [angiotensin-(1–12)] and its cleaving enzyme chymase are an essential source of Ang II p…
View article: Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts
Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts Open
Angiotensin-(1-12) [Ang-(1-12)], an alternate substrate for tissue angiotensin II (Ang II) formation, underscores the importance of alternative renin-independent pathway(s) for the generation of angiotensins. Since renin enzymatic activity…