Kengo Kawaguchi
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View article: Incidence and temporal trends of depression and anxiety following cancer diagnosis in Japan: Insights from the <scp>LIFE</scp> study
Incidence and temporal trends of depression and anxiety following cancer diagnosis in Japan: Insights from the <span>LIFE</span> study Open
Depression and anxiety are common among cancer patients and are associated with poorer treatment adherence, quality of life, and survival outcomes. While the prevalence of these conditions has been widely reported, less is known about thei…
View article: Rare presentation of primary synovial chondrosarcoma arising in the shoulder: a case report
Rare presentation of primary synovial chondrosarcoma arising in the shoulder: a case report Open
Synovial chondrosarcoma (CHS) is a rare malignant tumor arising from the synovial tissue and is often associated with synovial chondromatosis. Herein, we present a unique case of primary synovial CHS in the shoulder joint without evidence …
View article: Translocation in bone and soft tissue sarcomas: a comprehensive epidemiological investigation
Translocation in bone and soft tissue sarcomas: a comprehensive epidemiological investigation Open
This study highlights differences in the epidemiology and genetic rearrangements of sarcoma.
View article: Impact of COVID-19 pandemic on bone and soft tissue sarcoma patients’ consultation and diagnosis
Impact of COVID-19 pandemic on bone and soft tissue sarcoma patients’ consultation and diagnosis Open
The coronavirus disease (COVID-19) pandemic negatively affected the diagnosis and treatment of several cancer types. However, this pandemic's exact impact and extent on bone and soft tissue sarcomas need to be clarified. We aimed to invest…
View article: Evaluation of advanced emergency braking systems in drowsy driving-related real-world truck collisions
Evaluation of advanced emergency braking systems in drowsy driving-related real-world truck collisions Open
Study Objectives The effectiveness of advanced emergency braking systems (AEBS) in preventing drowsy driving-related truck collisions remains unclear. We aimed to evaluate the damage-mitigation effect of AEBS on drowsy driving-related coll…
View article: Breast mucoepidermoid carcinoma with a rare CRTC3–MAML2 fusion
Breast mucoepidermoid carcinoma with a rare CRTC3–MAML2 fusion Open
View article: Risk factors for collisions attributed to microsleep-related behaviors while driving in professional truck drivers
Risk factors for collisions attributed to microsleep-related behaviors while driving in professional truck drivers Open
Sleep-disordered breathing (SDB) is prevalent among professional drivers. Although SDB is a known risk factor for truck collisions attributed to microsleep-related behaviors at the wheel (TC-MRBs), the usefulness of overnight pulse oximetr…
View article: Impact of COVID-19 Pandemic on Bone and Soft Tissue Sarcoma Patients’ Consultation and Diagnosis
Impact of COVID-19 Pandemic on Bone and Soft Tissue Sarcoma Patients’ Consultation and Diagnosis Open
The coronavirus disease (COVID-19) pandemic negatively affected the diagnosis and treatment of several cancer types. However, the exact impact and extent of this pandemic on bone and soft tissue sarcomas have not been clarified. We aimed t…
View article: Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration
Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration Open
View article: Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma
Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma Open
View article: Metastatic malignant glomus tumor resistant to pazopanib, a multikinase inhibitor: A case report and review of literature
Metastatic malignant glomus tumor resistant to pazopanib, a multikinase inhibitor: A case report and review of literature Open
Malignant glomus tumors are extremely rare soft tissue tumors that are rich in tumor vessels. Due to its rarity, no treatment strategy other than resection has been established. Pazopanib, a multikinase inhibitor, is expected to improve th…
View article: Dashcam video footage-based analysis of microsleep-related behaviors in truck collisions attributed to falling asleep at the wheel
Dashcam video footage-based analysis of microsleep-related behaviors in truck collisions attributed to falling asleep at the wheel Open
Our dashcam video footage-based analysis in truck collisions attributed to falling asleep at the wheel revealed the process of changes in microsleep-related driver and vehicle behaviors, classified as anti-sleepiness behavior, behavioral s…
View article: Prognostic value of nuclear morphometry in myxoid liposarcoma
Prognostic value of nuclear morphometry in myxoid liposarcoma Open
Myxoid liposarcoma (MLS) accounts for 20%‐30% of liposarcoma and the round cell component (RCC) is believed to be a specific poor prognostic factor. However, the RCC assessment criteria are vaguely defined and, therefore, are inconsistentl…
View article: A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance
A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance Open
From this study, we propose a new histological scoring system for the grading of conventional chondrosarcoma, based on nuclear atypia, cellularity, necrosis, and myxoid change. Using this system, conventional chondrosarcoma may be clearly …
View article: Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma
Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma Open
View article: The recent bacterial etiology of childhood osteoarticular infections focusing on the vaccine initiation for Streptococcus pneumoniae and Haemophilus influenzae: A single-center retrospective analysis in Japan
The recent bacterial etiology of childhood osteoarticular infections focusing on the vaccine initiation for Streptococcus pneumoniae and Haemophilus influenzae: A single-center retrospective analysis in Japan Open
View article: Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment
Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment Open
View article: The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma
The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma Open
View article: Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma
Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma Open
Background Undifferentiated pleomorphic sarcoma (UPS) is a sarcoma with a poor prognosis. A clinical trial, SARC028, revealed that treatment with anti-PD-1 drugs was effective against UPS. Studies have reported that UPS expresses PD-L1, so…
View article: Frequent MN1 Gene Mutations in Malignant Peripheral Nerve Sheath Tumor
Frequent MN1 Gene Mutations in Malignant Peripheral Nerve Sheath Tumor Open
MN1 gene mutation was detected in more than half of our cases, it may have potential for use as a therapeutic target in vRH-MPNST.