Kenichi Hakamada
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View article: Nonoperative management of grade III pancreatic injuries in children: a case series
Nonoperative management of grade III pancreatic injuries in children: a case series Open
Introduction: Pediatric American Association for the Surgery of Trauma (AAST) Grade III pancreatic injuries—complete transections of the main pancreatic duct (MPD)—are rare, and long-term outcomes following nonoperative management are not …
View article: Impact of data compression and security devices on telesurgery systems
Impact of data compression and security devices on telesurgery systems Open
Purpose To evaluate the feasibility of secure telesurgery by assessing the impact of image compression and cybersecurity devices on surgical performance and data transmission. Methods Telesurgical procedures using the hinotori™ surgical ro…
View article: Significance of Pancreatic Steatosis as a Predictor of New-onset Diabetes Mellitus Following Pancreatectomy
Significance of Pancreatic Steatosis as a Predictor of New-onset Diabetes Mellitus Following Pancreatectomy Open
Background: Despite advancements in pancreatic surgery, new-onset diabetes mellitus following pancreatectomy (NODMP) persists, affecting patients’ quality of life. Predicting NODMP before surgery could significantly enhance postoperative c…
View article: Patients With Pancreatic Cancer With Synchronous Liver Oligometastasis Show a Significant Long‐Term Survival Benefit From Resection Under Specific Conditions: A Multicenter National Cohort Study
Patients With Pancreatic Cancer With Synchronous Liver Oligometastasis Show a Significant Long‐Term Survival Benefit From Resection Under Specific Conditions: A Multicenter National Cohort Study Open
Background In this study, we investigated the criteria that predict the long‐term survival benefits after surgical resection in patients with pancreatic cancer accompanied by liver oligometastasis. Methods In total, 60 patients from 34 hig…
View article: Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state
Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state Open
Pancreatic stellate cells (PSCs) are the origin of cancer-associated fibroblasts. Type 2 diabetes mellitus (T2D) may promote pancreatic ductal adenocarcinoma (PDAC), eliciting changes in the quiescent PSC (qPSC) population from the precanc…
View article: Prediction of the Therapeutic Response to Neoadjuvant Chemotherapy for Rectal Cancer Using a Deep Learning Model
Prediction of the Therapeutic Response to Neoadjuvant Chemotherapy for Rectal Cancer Using a Deep Learning Model Open
The non-invasive deep learning model using prechemotherapy CT images exhibited high predictive performance in predicting the pathological therapeutic response to SOX NAC.
View article: A Case of Acute Mesenteric Venous Thrombosis in a Patient with Ulcerative Colitis and Positive Antiphospholipid Antibodies That Was Successfully Treated with Two-Stage Total Proctocolectomy
A Case of Acute Mesenteric Venous Thrombosis in a Patient with Ulcerative Colitis and Positive Antiphospholipid Antibodies That Was Successfully Treated with Two-Stage Total Proctocolectomy Open
View article: Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries
Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries Open
View article: Integrated gross and microanatomical analysis of the periportal lymphatic system in human liver
Integrated gross and microanatomical analysis of the periportal lymphatic system in human liver Open
Background Although animal studies have indicated that the periportal lymphatic system is an important intrahepatic lymphatic route, detailed human studies are scarce. We studied the lymphatic pathways and dynamics around Glisson's capsule…
View article: Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases
Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases Open
Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if the metastases are resectable. Unfortunately, there is no reliable preope…
View article: Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Observational Study
Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Observational Study Open
In patients with mCRC-SPM, postoperative complications are infrequent for P1 with localized peritoneal dissemination, and PTR may be considered as aggressive treatment. Factors including age ≥75 years, rectal cancer, presence of liver meta…
View article: <i>VEGFA</i> Gene Expression in Breast Cancer Is Associated With Worse Prognosis, but Better Response to Chemotherapy and Immunotherapy
<i>VEGFA</i> Gene Expression in Breast Cancer Is Associated With Worse Prognosis, but Better Response to Chemotherapy and Immunotherapy Open
Our research indicates that high VEGFA BC confers high cell proliferation, reduced immune cell infiltration, and poorer survival, but allows better response to anthracycline- and taxane-based chemotherapy, and immunotherapy.
View article: A Case of Gastrojejunocolic Fistula Following Subtotal Stomach-preserving Pancreaticoduodenectomy with Undernutrition, Efficiently Managed Via Indirect Calorimetry
A Case of Gastrojejunocolic Fistula Following Subtotal Stomach-preserving Pancreaticoduodenectomy with Undernutrition, Efficiently Managed Via Indirect Calorimetry Open
Gastrojejunocolic fistula is a rare but serious complication of pancreaticoduodenectomy that can lead to malabsorption and severe undernutrition. A 59-year-old man presented with leg edema and significant weight loss 8 years after undergoi…
View article: The Feasibility of Telerobotic Pancreaticojejunostomy Using a Surgical Robot: A Pilot Study With Commercial Optical Networks
The Feasibility of Telerobotic Pancreaticojejunostomy Using a Surgical Robot: A Pilot Study With Commercial Optical Networks Open
Introduction In recent years, the practical application of remote robotic surgery has become a reality, and is expected to be applied to difficult surgeries. The purpose of this study is to demonstrate whether the pancreaticojejunostomy in…
View article: Long-term outcomes of S-1 and oxaliplatin neoadjuvant chemotherapy with total mesorectal excision and lateral lymph node dissection for rectal cancer
Long-term outcomes of S-1 and oxaliplatin neoadjuvant chemotherapy with total mesorectal excision and lateral lymph node dissection for rectal cancer Open
Although preoperative chemotherapy and TME with LLND are sufficient to control local recurrence, some cases will require more aggressive chemotherapy with radiation therapy.
View article: Updates on Breast Reconstruction: Surgical Techniques, Challenges, and Future Directions
Updates on Breast Reconstruction: Surgical Techniques, Challenges, and Future Directions Open
The increasing global incidence of breast cancer underscores the significance of breast reconstruction in enhancing patients' quality of life. Breast reconstruction primarily falls into two categories: implant-based techniques and autologo…
View article: DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer
DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer Open
View article: Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report Open
Background Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active metabolite, M-4, which is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1) and is excrete…
View article: Upfront surgery, neoadjuvant chemoradiotherapy, or neoadjuvant chemotherapy for rectal cancer with lateral lymph node metastasis: A multicenter MRI and lateral lymph node dissection study
Upfront surgery, neoadjuvant chemoradiotherapy, or neoadjuvant chemotherapy for rectal cancer with lateral lymph node metastasis: A multicenter MRI and lateral lymph node dissection study Open
Aim The purpose was to clarify the oncological outcomes of rectal cancer (RC) with lateral lymph node metastasis (LLNM) on high‐resolution MRI (HRMRI), considering preoperative treatments. Methods Two hundred and twelve patients, from 13 h…
View article: Optimal treatment strategy for patients with pancreatic cancer having positive peritoneal cytology: A nationwide multicenter retrospective cohort study supervised by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Optimal treatment strategy for patients with pancreatic cancer having positive peritoneal cytology: A nationwide multicenter retrospective cohort study supervised by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery Open
Background The aim of this study was to determine the optimal treatment for patients with pancreatic cancer (PaCa) having positive peritoneal cytology (PPC). Methods This multicenter retrospective study included patients with PPC treated a…
View article: Emergency resection of a congenital hepatoblastoma: A case report
Emergency resection of a congenital hepatoblastoma: A case report Open
Introduction: A congenital hepatoblastoma (CH) is a rare liver tumor that can lead to severe outcomes due to unexpected rapid tumor growth. We report a case of CH with respiratory and circulatory failure caused by tumor growth, in which th…
View article: Toll-Like Receptor 7-Expressed Macrophages Are Involved in the Pathogenesis of Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction
Toll-Like Receptor 7-Expressed Macrophages Are Involved in the Pathogenesis of Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction Open
Introduction: Esophageal achalasia is a typical esophageal motility disorder (EMD). Although viral infections have been hypothesized to play a role in the pathogenesis of esophageal achalasia, its etiology remains unclear. This study used …
View article: Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery
Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery Open
Nicotinamide adenine dinucleotide (NAD +) plays a pivotal role in numerous cellular functions. Reduced NAD + levels are postulated to be associated with cancer. As interest in understanding NAD + dynamics in cancer patients with therapeuti…
View article: Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression
Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression Open
View article: Clinical practice guidelines for telesurgery 2022
Clinical practice guidelines for telesurgery 2022 Open
View article: A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure
A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure Open
View article: Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component
Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component Open
View article: Postoperative long‑term outcomes of acute normovolemic hemodilution in pancreatic cancer: A propensity score matching analysis
Postoperative long‑term outcomes of acute normovolemic hemodilution in pancreatic cancer: A propensity score matching analysis Open
Acute normovolemic hemodilution (ANH) is a useful intraoperative blood conservation technique. However, the impact on long-term outcomes in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The present study investigated the impact …
View article: Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?
Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma? Open
Background Surgical resection is standard treatment for invasive intraductal papillary mucinous carcinoma (IPMC); however, impact of multidisciplinary treatment on survival including postoperative adjuvant therapy (AT), neoadjuvant therapy…
View article: Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery
Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery Open
Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in numerous cellular functions. Reduced NAD+ levels are postulated to be associated with cancer. As interest in understanding NAD+ dynamics in cancer patients with therapeutic a…