Explanipedia

Eleven‐year trends in walnut‐induced anaphylaxis in children in Japan: A multicenter retrospective study Open

Yuna Iwashita, Naoki Kajita, Koichi Yoshida, Masako Fujiwara, Kento Takahashi , et al. · 2025

Background In recent years, the prevalence of walnut allergies has been increasing worldwide; however, the trends and clinical characteristics of walnut‐induced anaphylaxis remain unclear. Herein, we evaluated the changes in the incidence …

WHEAT ALLERGY, A NEW AND EMERGING THREAT OF FOOD ALLERGY FOR CHILDREN Open

Pakit Vichyanond, Ken‐ichi Nagakura, Punchama Pacharn, Gary Wong, Hugh A. Sampson · 2025

Factors associated with egg aversion after a negative oral food challenge result in children with egg allergies: A multicenter questionnaire survey in Japan Open

Naoko Fusayasu, Tomoyuki Asaumi, Ken‐ichi Nagakura, Kyohei Takahashi, Noriyuki Yanagida , et al. · 2025

About half of the children after negative OFC had an egg aversion, and it was associated with older age during negative OFC. Careful follow-up and guidance with consideration of less aversive cooking methods are important in older age grou…

Low‐dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan Open

Yuki Sakaguchi, Ken‐ichi Nagakura, Kyohei Takahashi, Hiroaki Taniguchi, Mika Ogata , et al. · 2025

Background Few studies have reported significant risk factors for allergic symptoms during low‐dose (1–3 mL) cow's milk (CM) oral food challenges (OFCs). We investigated patients from multiple centers in Japan to identify high‐risk, low‐do…

Cutting edge of oral immunotherapy (OIT): Differences between Japan and overseas Open

Ken‐ichi Nagakura, Motohiro Ebisawa · 2025

Three-year prognoses after low-dose oral food challenge for cow's milk Open

M. Tokunaga, Ken‐ichi Nagakura, Kyohei Takahashi, Sakura Sato, Motohiro Ebisawa , et al. · 2024

Failure in LD-OFC is associated with persistent CMA, whereas successful LD-OFC outcomes are associated with a favorable prognosis thereafter, irrespective of a history of anaphylaxis.

Current perspective on allergen immunotherapy for food allergies Open

Sakura Sato, Ken‐ichi Nagakura, Noriyuki Yanagida, Motohiro Ebisawa · 2024

Food allergies are an increasing global problem and societal issue. In addition to the potential for severe allergic reactions from accidental ingestion, food allergies impose a significant burden on the quality of life, nutrition, cost of…

Chapter 3 Epidemiology and risk factors for pediatric asthma and those managements Open

Ken‐ichi Nagakura, Motohiro Ebisawa · 2024

「小児気管支喘息・治療ガイドライン(JPGL)2023」の第3章疫学,発症の危険因子と一次,二次予防では,章立ての再編に伴い2点の大きな変更があった.1点目はJPGL2020までは異なる章で記載されていた小児喘息の疫学および発症の危険因子と予防の内容を一つの章にまとめて記載した点,2点目は急性増悪の危険因子を別章(第6章)での記載とした点である.その他では,「厚生労働省,小児アレルギー学会が実施している疫学調査」のデータを最新版に変更した点,近年の複数の国内大規模調査の結…

Timing of initial symptom onset during milk and wheat challenges: A retrospective study Open

Noriyuki Yanagida, Takanori Minoura, Sakura Sato, Kyohei Takahashi, Ken‐ichi Nagakura , et al. · 2024

Background Allergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices. The reported median times for the first symptom occurrence are 20–30 min …

Three-year prognosis after low-dose oral food challenge for children with wheat allergy Open

Takaaki Itonaga, Noriyuki Yanagida, Ken‐ichi Nagakura, Tomoyuki Asaumi, M. Tokunaga , et al. · 2024

LD-tolerant patients frequently acquired wheat tolerance within 3 years. Even if once positive, one-third could pass the re-administered LD-OFC within 3 years.

Accidental Allergic Reactions to Immediate-Type Food Allergens in Japanese Children: A Single-Center Study Open

Noriyuki Yanagida, Yoko Miura, Ken‐ichi Nagakura, Kyohei Takahashi, Sakura Sato , et al. · 2023

Background: Accidental allergic reactions (AAR) in children are under-studied, especially with precise pediatrician-based exact diagnoses and follow-ups. This study aimed to assess the prevalence and risk factors for AAR in Japanese childr…

Natural history of cow’s milk allergy: a prospective study in children aged 6 to 12 years Open

Noriyuki Yanagida, Kei Kubota, Ken‐ichi Nagakura, Yuki Ejiri, Sakura Sato , et al. · 2023

Background: Approximately 50–90% of children with immediate-type cow’s milk allergy (CMA) acquire tolerance by pre-school age. We aimed to investigate the tolerance acquisition rate of CMA in children aged 6–12 years. Methods: Children wit…

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers Open

Ken‐ichi Nagakura, Sakura Sato, Wakako Shinahara, Hiroshi Kido, Hidetoshi Fujita , et al. · 2023

Importance Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth i…

Long-term prognosis after low-dose peanut challenge for patients with history of anaphylaxis Open

Nobuko Akamatsu, Ken‐ichi Nagakura, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa · 2023

Long-term prognosis after low-dose peanut challenge for patients with history of anaphylaxisNobuko Akamatsu, MD, PhD1,2, Ken-ichi Nagakura, MD, PhD1, Sakura Sato, MD3, Noriyuki Yanagida, MD, PhD1,3,*, Motohiro Ebisawa, MD, PhD3 1Department…

Peanut, tree nuts, soy bean, sesame, buckwheat Open

Ken‐ichi Nagakura, Sakura Sato · 2022

「食物アレルギー診療ガイドライン(JGFA)2021」の第12章食品ごとの各論4,5,6,7では種子類であるピーナッツ,木の実類,大豆,ゴマ,ソバのアレルギーに関して新たに独立して章立てし,調査結果を最新の情報に更新した.その他では食品ごとの「自然歴」のデータを表にまとめて示した点,近年研究が進んでいる「コンポーネントを用いた診断」に関して詳細に説明した点,「ソバアレルギーの診断有用性」を表にまとめて説明した点などが食物アレルギー診療ガイドライン(JPGFA)2016から…

Prognosis of infantile food protein-induced enterocolitis syndrome to wheat: A case series Open

Noriyuki Yanagida, Makoto Nishino, Sakura Sato, Ken‐ichi Nagakura, Kyohei Takahashi , et al. · 2022

Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study Open

Shingo Yamada, Takao Fujisawa, Mizuho Nagao, Hiroshi Matsuzaki, Chikako Motomura , et al. · 2022

Background: Childhood asthma is a major risk for low lung function in later adulthood, but what factors in asthma are associated with the poor lung function during childhood is not known. Objective: To identify clinical factors in children…

Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020 Open

Yuichi Adachi, Takumi Takizawa, Masaki Futamura, Takao Fujisawa, Shigemi Yoshihara , et al. · 2022

Threshold and safe ingestion dose among infants sensitized to hen's egg Open

Masatoshi Mitomori, Noriyuki Yanagida, Makoto Nishino, Kyohei Takahashi, Ken‐ichi Nagakura , et al. · 2022

Appendix S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for t…

Phenotyping of immediate-type food allergies based on 10 years of research: A latent class analysis Open

Kyohei Takahashi, Noriyuki Yanagida, Takaaki Itonaga, Makoto Nishino, Ken‐ichi Nagakura , et al. · 2022

Background: Food allergy is a disease with a diverse and variable natural history, and some patients may react to two or more food antigens. This study aimed to classify and characterize the long-term prognosis of infantile-onset, immediat…

Testing for immediate-type food allergy How far can testing diagnose allergies in children? The progress in testing for allergic disease Open

Ken‐ichi Nagakura, Motohiro Ebisawa · 2022

即時型食物アレルギーの診断のGold standardは食物経口負荷試験(OFC)であるが,他の検査によりOFCのリスクを軽減できる.

Author response for "Anaphylaxis to winter melon due to cross‐reactivity of sensitization to ragweed pollen" Open

Ken‐ichi Nagakura, Mari Takei, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa · 2022

Threshold and safe ingestion dose among infants sensitized to hen's egg Open

Masatoshi Mitomori, Noriyuki Yanagida, Makoto Nishino, Kyohei Takahashi, Ken‐ichi Nagakura , et al. · 2022

Threshold and safe ingestion dose among infants sensitized to hen’s eggMasatoshi Mitomori,a Noriyuki Yanagida,aMakoto Nishino,a Kyohei Takahashi,aKen-ichi Nagakura,a Kiyotake Ogura,aMari Takei,b Sakura Sato,b Motohiro EbisawabaDepartment o…

Commentary Japanese Pediatric Guideline for The Treatment and Management of Asthma 2020 Chapter4 Risk factors for pediatric asthma and those managements Open

Ken‐ichi Nagakura, Motohiro Ebisawa · 2021

「小児気管支喘息治療・管理ガイドライン（JPGL）2020」の第4章危険因子とその対策では気管支喘息の発症に関わる個体因子と環境因子，急性増悪（発作）に関わる環境因子の調査結果を最新の情報に更新した．その他では，環境因子において近年注目されている「マイクロバイオーム」，「抗菌薬」，「母体への薬物投与」に関して新たに項立てした点，喘息の診療に重要である「室内環境整備のポイント」に関して図を用いた説明を加えた点，「海外の喘息ガイドラインにおける喘息の発症予防および増悪予防の指…

Low-dose oral immunotherapy for walnut allergy with anaphylaxis: Three case reports Open

Koki Sasamoto, Ken‐ichi Nagakura, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa · 2021

Review for "The role of the environment in shaping the trends of childhood asthma – an Asian perspective" Open

Ken‐ichi Nagakura · 2021

Issue Information ‐ TOC Open

Philippe Eigenmann, Ken‐ichi Nagakura, Sakura Sato, Tomoyuki Asaumi, Noriyuki Yanagida , et al. · 2020

Maternal microbiome regulation prevents early allergic

Safe egg yolk consumption after a negative result for low‐dose egg oral food challenge Open

Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Tomoyuki Asaumi, Ken‐ichi Nagakura , et al. · 2020

Background Hen's egg is one of the most common allergens causing infantile food allergy. Consuming heated egg yolk slightly contaminated with egg white (EY with scEW) improves diet quality. Most children with egg allergies can safely consu…

Author response for "Timing of onset of allergic symptoms following low-dose milk and egg challenges" Open

Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Kiyotaka Ohtani, Shigehito Emura , et al. · 2020

Randomized controlled trial of oral immunotherapy for children with severe cow’s milk allergy: heated milk vs. unheated milk Open

Ken‐ichi Nagakura, Noriyuki Yanagida, Makoto Nishino, Kyohei Takahashi, Sakura Sato , et al. · 2020

During cow's milk oral immunotherapy (OIT), adverse reactions, including anaphylaxis, may develop. Although there are some case reports on OIT using heated milk (HM), the safety and efficacy of HM or unheated milk (UM) in the same protocol…

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