Kenichiro Nagahama
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View article: Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders
Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders Open
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects of synap…
View article: Tagging active neurons by soma-targeted Cal-Light
Tagging active neurons by soma-targeted Cal-Light Open
Verifying causal effects of neural circuits is essential for proving a direct circuit-behavior relationship. However, techniques for tagging only active neurons with high spatiotemporal precision remain at the beginning stages. Here we dev…
View article: Tagging active neurons by soma-targeted Cal-Light
Tagging active neurons by soma-targeted Cal-Light Open
Verifying causal effects of neural circuits is essential for proving direct a circuit-behavior relationship. However, techniques for tagging only active neurons with high spatiotemporal precision remain at the beginning stages. Here we dev…
View article: Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities
Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities Open
SETD1A encodes a histone methyltransferase whose de novo mutations are identified in schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate Setd1a mutant mice carrying the frameshift mutation that close…