Explanipedia

Parechovirus-A3 Infection in Neonates and Young Infants from the Pre-Coronavirus Disease 2019 Pandemic Period to the Post-Restriction Era from the Pediatric Parechovirus Surveillance Group in Japan Open

Yuta Aizawa, Jun Tachikawa, Tatsuki Ikuse, Kenji Furuno, Meiwa Shibata , et al. · 2025

Background The coronavirus disease 2019 (COVID-19) pandemic affected the epidemiology of community-acquired infectious diseases; however, the data on the effects of the pandemic on parechovirus-A3 (PeV-A3) circulation remain incomplete. Me…

Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome Open

Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu , et al. · 2025

Objective Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeu…

P-1210. Resurgence of Parechovirus-A3 Infection in Neonates and Young Infants after the Coronavirus Disease 2019 Pandemic in Japan Open

Yuta Aizawa, Jun Tachikawa, Takayuki Yamanaka, Takayo Shoji, Kazuya Ito , et al. · 2025

Background Parechovirus-A (PeV-A), especially PeV-A3, is a common cause of viral sepsis and encephalitis in neonates and young infants (age < 4 months). The strict infection control measures and non-pharmaceutical interventions of the c…

Respiratory viral infections and Kawasaki disease: A molecular epidemiological analysis Open

Kentaro Marutani, Kenji Murata, Yumi Mizuno, Sagano Onoyama, Takayuki Hoshina , et al. · 2024

Recent infection with RSV, PIV3, or AdV, occasionally in conjunction with other viruses, may contribute to the pathogenesis of KD as infrequent complications.

Evolutionary dynamics of the novel ST22-PT methicillin-resistant Staphylococcus aureus clone co-harbouring Panton–Valentine leucocidin and duplicated toxic shock syndrome toxin 1 genes Open

Tetsuo Yamaguchi, Kenji Furuno, Kohji Komori, Tomoko Abe, Takahiro Sato , et al. · 2024

Fukuoka clone I may have integrated a novel pathogenicity island bearing the TSST-1 gene, leading to the emergence of Fukuoka clone II with a duplicated TSST-1 gene. This duplication subsequently instigated a chromosomal inversion in a lar…

<span>CD14</span> down‐modulation as a real‐time biomarker in Kawasaki disease Open

Yutaro Inada, Motoshi Sonoda, Yumi Mizuno, Kenichiro Yamamura, Yoshitomo Motomura , et al. · 2023

Objectives The objectives of this study were to investigate the pathophysiology of Kawasaki disease (KD) from immunological and oxidative stress perspectives, and to identify real‐time biomarkers linked to innate immunity and oxidative str…

Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results Open

Abbie Oey, Matthew W. McClure, Julian Symons, Sushmita Chanda, John Fry , et al. · 2023

Respiratory syncytial virus (RSV) infection is the leading cause of infant hospitalizations and mortality. Lumicitabine, an oral nucleoside analog was studied for the treatment of RSV. The phase 1b and phase 2b studies reported here assess…

Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease Open

Joseph B. Domachowske, Yue Chang, Victoria Atanasova, Fernando Cabañas, Kenji Furuno , et al. · 2023

In children with congenital heart disease and/or chronic lung disease entering their second respiratory syncytial virus (RSV) season, 200 mg nirsevimab had a similar safety profile to that of palivizumab and resulted in nirsevimab serum ex…

Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression Open

Taichi Kato, Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Naoya Fukushima , et al. · 2023

Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors associated with CAA regression have not been well analyzed. Methods and Re…

Severe encephalopathy associated with SARS-CoV-2 Omicron BA.1 variant infection in a neonate Open

Kenichi Tetsuhara, Satoshi Akamine, Yoshie Matsubara, Shunsuke Fujii, Wataru Kashimada , et al. · 2022

Appropriate management of Kawasaki disease patients with coronary artery aneurysms: an interim report on a multicentric prospective registry study three years after commencement Open

Yutaro Koyama, Masaru Miura, Tohru Kobayashi, Tatsunori Hokosaki, Eisuke Suganuma , et al. · 2022

The remote prognosis of patients with Kawasaki disease (KD) complicated by coronary artery aneurysms (CAA) is still unclear. The present, multicentric registry study aimed to study the factors associated with coronary events (CE) and deter…

Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity Open

Joseph B. Domachowske, Shabir A. Madhi, Eric A. F. Simões, Victoria Atanasova, Fernando Cabañas , et al. · 2022

The efficacy and safety of nirsevimab in the treatment of medically attended respiratory syncytial virus (RSV) infections of the lower respiratory tract in otherwise healthy, late preterm and term infants were assessed in the phase 2B1 and…

Effect of delayed palivizumab administration on respiratory syncytial virus infection-related hospitalisation Open

Akiko Kamori, Yuya Morooka, Kenichiro Yamamura, Pin Fee Chong, Noriko Kuga , et al. · 2021

Respiratory syncytial virus (RSV) infection is an important cause of hospitalization in infants and young children. Monthly administration of palivizumab during the RSV season is effective in preventing severe infections in children with c…

Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan Open

Kenji Murata, Sagano Onoyama, Kenichiro Yamamura, Yumi Mizuno, Kenji Furuno , et al. · 2021

The causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-contro…

Assessment of Pediatric Admissions for Kawasaki Disease or Infectious Disease During the COVID-19 State of Emergency in Japan Open

Takuya Hara, Kenji Furuno, Kenichiro Yamamura, Junji Kishimoto, Yumi Mizuno , et al. · 2021

In this study, the significantly increased incidence of KD compared with respiratory tract and gastrointestinal infections during the COVID-19 state of emergency suggests that contact or droplet transmission is not a major route for KD dev…

The Impact of the COVID-19 State of Emergency on the Incidence of Kawasaki Disease in Japan: A Multicenter Observational Study Open

Takuya Hara, Kenji Furuno, Kenichiro Yamamura, Junji Kishimoto, Yumi Mizuno , et al. · 2020

An infant with streptococcal uvulitis presenting with airway obstruction Open

Yuya Morooka, Kenji Furuno · 2020

Infantile osteomyelitis of the fourth rib causing the occurrence of a lung abscess Open

Sayo Mori, Sagano Onoyama, Tomoko Takimoto, Yuya Morooka, Kenji Furuno · 2019

Infantile osteomyelitis of the rib is rare but can be complicated by intrapleural pyogenic lesions. Even if findings suggest another infection focus, osteomyelitis should be considered if there are changes on radiographs. In addition, it c…

Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events Open

Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Mamoru Ayusawa, Ryuji Fukazawa , et al. · 2018

Classification using the internal diameter z score is useful for assessing the severity of CAA in relation to the time-dependent occurrence of CE and associated factors in patients with KD. Careful management of CE is necessary for all pat…

Clarithromycin Plus Intravenous Immunoglobulin Therapy Can Reduce the Relapse Rate of Kawasaki Disease: A Phase 2, Open‐Label, Randomized Control Study Open

Etsuro Nanishi, Hisanori Nishio, Hidetoshi Takada, Kenichiro Yamamura, Mitsuharu Fukazawa , et al. · 2017

Background We previously reported that biofilms and innate immunity contribute to the pathogenesis of Kawasaki disease. Therefore, we aimed to assess the efficacy of clarithromycin, an antibiofilm agent, in patients with Kawasaki disease. …

Nasopharyngeal glial heterotopia with delayed postoperative meningitis Open

Kenichi Maeda, Kenji Furuno, Pin Fee Chong, Takato Morioka · 2017

A male infant, who underwent radical resection of a large glial heterotopia at the nasopharynx at 8 days, developed delayed postoperative bacterial meningitis at 9 months. Neuroradiological examination clearly demonstrated that meningitis …

Bilateral hydronephrosis due to obstructive ureteral stone associated with norovirus gastroenteritis Open

Fumihiro Ochi, Kenji Furuno, Pin Fee Chong, Junichiro Tezuka, Yumi Mizuno , et al. · 2017

Key Clinical Message Recently, cases of urinary tract calculi causing hydronephrosis and postrenal renal failure associated with viral gastroenteritis were documented, yet few were related to norovirus. During norovirus gastroenteritis, ob…

Bacteriological Analysis of Pneumococcus Detected from the Sputum of Hospitalized Children Open

Tomoko Abe, Kenji Furuno, Bin Chang, Tomonobu Aoki · 2017

7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine immunization schedule since April 2013 in Japan. Serotype replacement - a phenomenon by which serotypes are replaced by non-vaccine serotypes after vaccine int…

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