Explanipedia

Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression Open

Taichi Kato, Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Naoya Fukushima , et al. · 2023

Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors associated with CAA regression have not been well analyzed. Methods and Re…

Vasculitis of Vasa Vasorum and Aneurysm Formation in Kawasaki Disease: Predilection for Coronary Arteries Lesions Open

Zenshiro Onouchi, Akiko Hamaoka‐Okamoto, Chinatsu Suzuki, Kenji Hamaoka · 2021

Backgrounds. The mechanism causing coronary artery lesions in Kawasaki disease (KD) has not yet been fully clarified. Objective. We hypothesized that the main coronary artery (MCA) segment perfused by the vasa vasorum (VV) ar…

JCS/JSCS 2020 Guideline on Diagnosis and Management of Cardiovascular Sequelae in Kawasaki Disease Open

Ryuji Fukazawa, Junjiro Kobayashi, Mamoru Ayusawa, Hiromichi Hamada, Masaru Miura , et al. · 2020

Emergence and Characterization of Acute Coronary Syndrome in Adults After Confirmed or Missed History of Kawasaki Disease in Japan: A Japanese Nationwide Survey Open

Yoshihide Mitani, Etsuko Tsuda, Hitoshi Kato, Takashi Higaki, Masako Fujiwara , et al. · 2019

Background: Acute coronary syndrome (ACS), which is emerging in adults long after confirmed (followed-up or lost-to-follow), or missed Kawasaki disease (KD), is poorly characterized. Methods and Results: A Japanese retrospect…

Aetiological Significance of Infectious Stimuli in Kawasaki Disease Open

Akihiro Nakamura, Kazuyuki Ikeda, Kenji Hamaoka · 2019

Kawasaki disease (KD) is a pediatric vasculitis syndrome that is often involves coronary artery lesions (e. g., coronary artery aneurysms). Although its causal factors and entire pathogenesis remain elusive, the available evidence indicate…

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Streptococcus sanguinis Sepsis Open

Hitoshi Awaguni, Jun Shinozuka, Shinichiro Tanaka, Sayaka Kadowaki, Shigeru Makino , et al. · 2018

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human her…

Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events Open

Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Mamoru Ayusawa, Ryuji Fukazawa , et al. · 2018

Classification using the internal diameter z score is useful for assessing the severity of CAA in relation to the time-dependent occurrence of CE and associated factors in patients with KD. Careful management of CE is necessary for all pat…

Nationwide Survey of Patients With Giant Coronary Aneurysm Secondary to Kawasaki Disease 1999–2010 in Japan Open

Ryuji Fukazawa, Tohru Kobayashi, Masashi Mikami, Tsutomu Saji, Kenji Hamaoka , et al. · 2017

Severe cardiac events are likely to occur within 2 years from onset of Kawasaki disease, while no deaths occurred beyond this time. Hence, careful monitoring is needed especially for the first 2 years. Most patients with giant coronary ane…

The Application of a Modified d-ROMs Test for Measurement of Oxidative Stress and Oxidized High-Density Lipoprotein Open

Fumiaki Ito, Tomoyuki Ito, Chinatsu Suzuki, Tomoyo Yahata, Kazuyuki Ikeda , et al. · 2017

Reactive oxygen species (ROS) are involved in the initiation and progression of atherosclerosis. ROS-derived hydroperoxides, as an indicator of ROS production, have been measured by using the diacron reactive oxygen metabolites (d-ROMs) te…

Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model Open

Kazuyuki Ikeda, Yasutaka Mizoro, Tomonaga Ameku, Yui Nomiya, Shin-Ichi Mae , et al. · 2016

The first iPSC-based model for KD is reported here. Our mechanistic analyses suggest thatCXCL12, which plays a role in leukocyte transmigration, is a key molecule candidate for IVIG resistance and KD severity. They also indicate that an up…

Oxidative stress and Kawasaki disease: how is oxidative stress involved from the acute stage to the chronic stage? Open

Tomoyo Yahata, Kenji Hamaoka · 2016

Inflammation and oxidative stress are closely related. Further, oxidative stress plays an important role in the pathology of inflammation-based Kawasaki disease. An excessive in vivo production of reactive oxygen species increases oxidativ…

Histopathological Characteristics of Post-inflamed Coronary Arteries in Kawasaki Disease-like Vasculitis of Rabbits Open

Maiko Fujii, Hideo Tanaka, Akihiro Nakamura, Chinatsu Suzuki, Yoshinori Harada , et al. · 2016

Kawasaki disease (KD) is a systemic vasculitis in infants that develops predominantly in the coronary arteries. Despite the clinically transient nature of active inflammation in childhood albeit rare complications (e.g., coronary artery an…

Combined Alport syndrome and Klinefelter syndrome Open

Masashi Nishida, Fusako Hashimoto, Hiroshi Kaito, Kandai Nozu, Kazumoto Iijima , et al. · 2015

To date, there have been a very limited number of case reports on combined Alport syndrome (AS) and Klinefelter syndrome (KS). We herein describe the case of a 9‐month‐old boy diagnosed with concomitant AS and KS. KS was detected on chromo…

Oxidative Stress in Kawasaki Disease Vasculitis Open

Kenji Hamaoka, Tomoyo Yahata, MD Akiko Okamoto, Chinatsu Suzuki, Yuki Kutsuk , et al. · 2015

Although the underlying mechanisms by which Kawasaki disease (KD) triggers vasculitis remain unclear, certain stimuli that release inflammatory substances trigger vasculitis during its acute phase, and may continue to cause vascular deteri…

<span>I</span>g<span>A</span> nephropathy in a girl with mitochondrial disease Open

Masashi Nishida, Masafumi Morimoto, Kunihiko Ohno, Kenji Hamaoka · 2015

Mitochondrial renal disease is one of the important causes of end‐stage renal disease in children and its incidence may be underestimated. We here describe the case of a 13‐year‐old girl who was diagnosed with mitochondrial disease ( MD ) …

Anti-inflammatory Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor on Acute Coronary Arteritis in A Rabbit Model of Kawasaki Disease Open

Kenji Hamaoka, Seiichiro Ozawa · 2015

Background: Recent observations suggest that some of the clinical benefits associated with statin therapy are pleiotropic, i.e., they are independent of their cholesterol-inhibiting action.In this study, we attempted to evaluate the anti-i…

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