Kenji Maeda
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View article: Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment
Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment Open
Retroviruses integrate their genetic material into the host genome, enabling persistent infection. Human T cell leukaemia virus type 1 (HTLV-1) and human immunodeficiency virus type 1 (HIV-1) share similarities in genome structure and targ…
View article: A high-throughput, fully automated competition assay to evaluate SARS-CoV-2 neutralizing responses and epitope specificity in clinical samples
A high-throughput, fully automated competition assay to evaluate SARS-CoV-2 neutralizing responses and epitope specificity in clinical samples Open
Coronavirus disease-2019 (COVID-19) remains a critical global health concern. We developed a fully automated, high-throughput competition immunoassay to elucidate how epitope recognition on the severe acute respiratory syndrome coronavirus…
View article: Role of <i>N</i>-glycosylation as a determinant of ATG9A conformations and activity
Role of <i>N</i>-glycosylation as a determinant of ATG9A conformations and activity Open
In this study we investigate the effects of glycosylation at position N99 on the structural dynamics and lipid scrambling activity of ATG9A, a key autophagy protein, using microsecond all-atom molecular dynamics (MD) simulations. ATG9A is …
View article: Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis
Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis Open
Nutrient deprivation is a major trigger of autophagy, a conserved quality control and recycling process essential for cellular and tissue homeostasis. In a high-content image-based screen of the human ubiquitome, we here identify the E3 li…
View article: Current Status of Electrolyzed Water Hemodialysis
Current Status of Electrolyzed Water Hemodialysis Open
View article: Population Pharmacokinetics of Brexpiprazole in Japanese Healthy Subjects and Patients with Schizophrenia
Population Pharmacokinetics of Brexpiprazole in Japanese Healthy Subjects and Patients with Schizophrenia Open
Brexpiprazole, widely approved for the treatment of schizophrenia, is an atypical antipsychotic that modulates serotonin–dopamine activity. To better understand the pharmacokinetics (PK) of brexpiprazole in Japanese patients, a population …
View article: Evaluating the Use of Sacran, a Polysaccharide Isolated from Aphanothece sacrum, as a Possible Microbicide for Preventing HIV-1 Infection
Evaluating the Use of Sacran, a Polysaccharide Isolated from Aphanothece sacrum, as a Possible Microbicide for Preventing HIV-1 Infection Open
Since combination antiretroviral therapy (cART) was introduced to treat human immunodeficiency virus type-1 (HIV-1)/acquired immunodeficiency syndrome (AIDS), the AIDS mortality rate has markedly decreased, and convalescence in individuals…
View article: Protection of Omicron Bivalent Vaccine, Previous Infection, and Their Induced Neutralizing Antibodies Against Symptomatic Infection With Omicron XBB.1.16 and EG.5.1
Protection of Omicron Bivalent Vaccine, Previous Infection, and Their Induced Neutralizing Antibodies Against Symptomatic Infection With Omicron XBB.1.16 and EG.5.1 Open
Background Data are limited on the protective role of the Omicron BA bivalent vaccine, previous infection, and their induced neutralizing antibodies against Omicron XBB.1.16 and EG.5.1 infection. Methods We conducted a nested case-control …
View article: Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium <em>Aphanothece sacrum</em>, as a Microbicide Candidate
Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium <em>Aphanothece sacrum</em>, as a Microbicide Candidate Open
Since cART was introduced to treat AIDS, the mortality rate due to AIDS has markedly decreased and the convalescence of HIV-infected individuals has improved drastically. However, HIV-1 sexual transmission has made HIV become a global epid…
View article: Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations
Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations Open
View article: Brexpiprazole: A new option in treating agitation in Alzheimer's dementia—Insights from transgenic mouse models
Brexpiprazole: A new option in treating agitation in Alzheimer's dementia—Insights from transgenic mouse models Open
Aim Brexpiprazole is the first FDA‐approved treatment for agitation associated with dementia due to Alzheimer's disease. Agitation in Alzheimer's dementia (AAD) occurs in high prevalence and is a great burden for patients and caregivers. E…
View article: Protection of Omicron bivalent vaccine, previous infection, and their induced neutralizing antibodies against symptomatic infection with Omicron XBB.1.16 and EG.5.1
Protection of Omicron bivalent vaccine, previous infection, and their induced neutralizing antibodies against symptomatic infection with Omicron XBB.1.16 and EG.5.1 Open
Background Data are limited on the protective role of the Omicron BA bivalent vaccine, previous infection, and their induced neutralizing antibodies against Omicron XBB.1.16 and EG.5.1 infection. Methods We conducted a nested case-control …
View article: Intragenic silencer regulates human retrovirus latency by recruiting RUNX1
Intragenic silencer regulates human retrovirus latency by recruiting RUNX1 Open
Retroviruses integrate viral genome DNA into the host cellular genome. The integrated proviral DNA serves as a template for the production of progeny viruses. There are many points of similarity between two human retroviruses, human T-cell…
View article: HIV-Tocky system to visualize proviral expression dynamics
HIV-Tocky system to visualize proviral expression dynamics Open
View article: HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection Open
Combination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chroni…
View article: Correction for Nakajima et al., “Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations”
Correction for Nakajima et al., “Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations” Open
View article: High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with in vitro viral neutralizing activity
High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with in vitro viral neutralizing activity Open
Quantitative S-IgG tests are a useful and convenient tool for estimating in vitro virus-neutralizing activity, with a high correlation with IgG-EC50 when the rational cut-off value is carefully determined.
View article: Efficacy and Safety of Treatment with Plasma from COVID-19-Recovered Individuals
Efficacy and Safety of Treatment with Plasma from COVID-19-Recovered Individuals Open
Convalescent plasma therapy, which involves administering plasma from recovered coronavirus disease 2019 (COVID-19) patients to infected individuals, is being explored as a potential treatment for severe cases of COVID-19. This study aims …
View article: HIV-Tocky system to visualize proviral expression dynamics
HIV-Tocky system to visualize proviral expression dynamics Open
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing. In vitro reporter models so far offered a feasible means to i…
View article: Trends of participants in convalescent plasma donation for COVID-19 in Japan as the pandemic evolved
Trends of participants in convalescent plasma donation for COVID-19 in Japan as the pandemic evolved Open
As outbreaks of emerging infectious disease occur, it is desirable to construct and implement a scheme for convalescent plasma donation promptly and to monitor the eligibility rate over time. If it declines, promptly analyze and resolve th…
View article: Preinfection Neutralizing Antibodies, Omicron BA.5 Breakthrough Infection, and Long COVID: A Propensity Score-Matched Analysis
Preinfection Neutralizing Antibodies, Omicron BA.5 Breakthrough Infection, and Long COVID: A Propensity Score-Matched Analysis Open
Background Data are limited on the role of preinfection humoral immunity protection against Omicron BA.5 infection and long coronavirus disease (COVID) development. Methods We conducted nested case-control analysis among tertiary hospital …
View article: Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model
Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model Open
View article: HIV-Tocky system to visualize proviral expression dynamics
HIV-Tocky system to visualize proviral expression dynamics Open
The stably integrated pool of HIV-1 proviruses in the host genome stands against curative strategies. This reservoir is extremely heterogeneous with respect to host cell type, anatomical location, integration site, and replication fitness.…
View article: Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial
Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial Open
View article: Omicron BA.1 neutralizing antibody response following Delta breakthrough infection compared with booster vaccination of BNT162b2
Omicron BA.1 neutralizing antibody response following Delta breakthrough infection compared with booster vaccination of BNT162b2 Open
Background Longitudinal data are lacking to compare booster effects of Delta breakthrough infection versus third vaccine dose on neutralizing antibodies (NAb) against Omicron. Methods Participants were the staff of a national research and …
View article: Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity
Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity Open
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Pre-infection neutralizing antibodies, Omicron BA.5 breakthrough infection, and long COVID: a propensity score-matched analysis
Pre-infection neutralizing antibodies, Omicron BA.5 breakthrough infection, and long COVID: a propensity score-matched analysis Open
Importance Investigating the role of pre-infection humoral immunity against Omicron BA.5 infection risk and long COVID development is critical to inform public health guidance. Objective To investigate the association between pre-infection…
View article: Supplementary Table S1 and Supplementary Figures S1-S6 from Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca<sup>2+</sup> Release and Cyclic AMP
Supplementary Table S1 and Supplementary Figures S1-S6 from Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca<sup>2+</sup> Release and Cyclic AMP Open
Table S1 list the resources used. Figures S1-S5 supplement the data presented in figures 1-6 and Figure S6 provides a schematic presentation of the proposed CAD signaling pathway.
View article: Supplementary Table S1 and Supplementary Figures S1-S6 from Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca<sup>2+</sup> Release and Cyclic AMP
Supplementary Table S1 and Supplementary Figures S1-S6 from Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca<sup>2+</sup> Release and Cyclic AMP Open
Table S1 list the resources used. Figures S1-S5 supplement the data presented in figures 1-6 and Figure S6 provides a schematic presentation of the proposed CAD signaling pathway.