Kenji Onoue
YOU?
Author Swipe
View article: Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry
Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry Open
As the first large-scale prospective registry of FD patients in Japan, this study has provided valuable baseline data for the cardiac features and management of FD.
View article: Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: From Sarcomere to Clinic
Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: From Sarcomere to Clinic Open
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by unexplained left ventricular hypertrophy, often resulting from pathogenic variants of sarcomeric protein genes. Conventional treatments, such as the use of …
View article: Global Low-Density Lipoprotein Cholesterol Targets for Patients With Acute Coronary Syndrome ― Current Guidelines and Clinical Pathways ―
Global Low-Density Lipoprotein Cholesterol Targets for Patients With Acute Coronary Syndrome ― Current Guidelines and Clinical Pathways ― Open
The management of low-density lipoprotein cholesterol (LDL-C) in patients with atherosclerotic cardiovascular disease, particularly those with acute coronary syndrome (ACS), has evolved significantly. Recent evidence emphasizes the importa…
View article: p22phox prevents the oxidation of SERCA2a and stabilizes it in the heart
p22phox prevents the oxidation of SERCA2a and stabilizes it in the heart Open
Sarcoplasmic/endoplasmic reticulum (SR/ER) Ca2+ ATPase 2a (SERCA2a) mediates Ca2+ reuptake into the SR in cardiomyocytes. The inactivation or downregulation of SERCA2a leads to reduced contractility in the failing hea…
View article: Prognostic Factors Associated With Early Recovery From Veno‐Arterial Extracorporeal Membrane Oxygenation Support in Patients With Fulminant Myocarditis
Prognostic Factors Associated With Early Recovery From Veno‐Arterial Extracorporeal Membrane Oxygenation Support in Patients With Fulminant Myocarditis Open
Background Fulminant myocarditis is life‐threatening and often requires mechanical circulatory support. Predicting its clinical course is crucial, yet data on early recovery predictors, particularly with veno‐arterial extracorporeal membra…
View article: Current Status and Prospects of Regional Collaborative Pathways for Management of Acute Coronary Syndrome in Japan ― A Nationwide Survey ―
Current Status and Prospects of Regional Collaborative Pathways for Management of Acute Coronary Syndrome in Japan ― A Nationwide Survey ― Open
Regional collaborative clinical pathways for ACS patients in Japan show variable implementation across prefectures, with approximately one-third of prefectures having established pathways. Future efforts should prioritize the establishment…
View article: Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry
Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry Open
View article: Prognostic Nutritional Index in Risk of Mortality Following Fulminant Myocarditis
Prognostic Nutritional Index in Risk of Mortality Following Fulminant Myocarditis Open
Aims Fulminant myocarditis (FM) is an acute fatal inflammation disease, but its chronic phase is unclear. A Japanese nationwide registry evaluated the long-term mortality in FM patients using a prognostic nutritional index (PNI). Methods a…
View article: Myocardial DNA Damage Is Responsible for the Relationship Between Genotype and Reverse Remodeling in Patients With Dilated Cardiomyopathy
Myocardial DNA Damage Is Responsible for the Relationship Between Genotype and Reverse Remodeling in Patients With Dilated Cardiomyopathy Open
View article: CORRIGENDUM: New Conversion Formula Between B-Type Natriuretic Peptide and N-Terminal-Pro-B-Type Natriuretic Peptide ― Analysis From a Multicenter Study ―
CORRIGENDUM: New Conversion Formula Between B-Type Natriuretic Peptide and N-Terminal-Pro-B-Type Natriuretic Peptide ― Analysis From a Multicenter Study ― Open
View article: Effects of Cardioprotective Drugs on 90-Day Mortality or Heart Transplantation in Patients With Fulminant Myocarditis
Effects of Cardioprotective Drugs on 90-Day Mortality or Heart Transplantation in Patients With Fulminant Myocarditis Open
Administration of ACEI or ARB during hospitalization was associated with favorable outcomes in terms of 90-day mortality and heart transplantation events in patients with clinically diagnosed FMP.
View article: Prognostic value of estimated plasma volume status at discharge in acute myocardial infarction
Prognostic value of estimated plasma volume status at discharge in acute myocardial infarction Open
Aims Congestive heart failure (HF) is a common complication in patients with acute myocardial infarction (AMI). The estimated plasma volume status [ePVS = (100 − haematocrit)/haemoglobin] is used as the blood plasma volume index to determi…
View article: Changes in Cardiac Function Following Fulminant Myocarditis
Changes in Cardiac Function Following Fulminant Myocarditis Open
BACKGROUND: The natural history of myocardial dysfunction in patients with fulminant myocarditis is poorly understood. This study aims to evaluate changes in cardiac function in patients with fulminant myocarditis using a nationwide regist…
View article: Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction
Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction Open
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 87…
View article: Multisystemic Inflammation Influences Prognosis in Fulminant Lymphocytic Myocarditis
Multisystemic Inflammation Influences Prognosis in Fulminant Lymphocytic Myocarditis Open
These results suggest that MSI may influence the prognosis of FLM, especially in patients aged <50 years.
View article: Optimizing Guideline-Directed Medical Therapy for Heart Failure ― Challenges and Strategies ―
Optimizing Guideline-Directed Medical Therapy for Heart Failure ― Challenges and Strategies ― Open
View article: Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role
Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role Open
Cardiac sarcoidosis (CS) is the scarring of heart muscles by autoimmunity, leading to heart abnormalities and patients with sarcoidosis with cardiac involvements have poor prognoses. Due to the small number of patients, it is difficult to …
View article: Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases
Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases Open
DNA damage determines the consequences of human heart failure. Assessment of DNA damage is useful to predict treatment efficacy and prognosis of heart failure patients with various underlying etiologies.
View article: Myocardial DNA damage combined with genotype predicts heart failure outcome in various underlying diseases
Myocardial DNA damage combined with genotype predicts heart failure outcome in various underlying diseases Open
Background Reliable predictors of treatment efficacy in heart failure have been long awaited. DNA damage has been implicated as a cause of heart failure. Purpose To investigate the association of DNA damage in myocardial tissue with treatm…
View article: Reevaluation of Intravenous Steroid Therapy for Histologically Confirmed Myocarditis with Fulminant Presentation: Insights from the Japanese Registry of Fulminant Myocarditis
Reevaluation of Intravenous Steroid Therapy for Histologically Confirmed Myocarditis with Fulminant Presentation: Insights from the Japanese Registry of Fulminant Myocarditis Open
Background The efficacy of intravenous steroids (IS) in patients with fulminant myocarditis presentation (FMP) remains controversial. We aimed to compare the clinical outcomes between patients with FMP who received IS (IS(+)) and not recei…
View article: Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction
Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction Open
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 87…
View article: Derivation and validation of a clinical predictive model of NT-proBNP ≥125 pg/mL to detect pre-heart failure
Derivation and validation of a clinical predictive model of NT-proBNP ≥125 pg/mL to detect pre-heart failure Open
Based on available clinical and laboratory variables, we developed and validated a new risk score to predict NT-proBNP ≥125 pg/mL in patients at risk for HF or with pre-HF.
View article: Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1
Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1 Open
View article: Heart failure with preserved ejection fraction phenogroup classification using machine learning
Heart failure with preserved ejection fraction phenogroup classification using machine learning Open
Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a complex syndrome with a poor prognosis. Phenotyping is required to identify subtype‐dependent treatment strategies. Phenotypes of Japanese HFpEF patients are not fully e…
View article: New Classification for the Combined Assessment of the Fractional Excretion of Urea Nitrogen and Estimated Plasma Volume Status in Acute Heart Failure
New Classification for the Combined Assessment of the Fractional Excretion of Urea Nitrogen and Estimated Plasma Volume Status in Acute Heart Failure Open
Background The fractional excretion of urea nitrogen (FEUN) has been used as a renal blood flow index related to cardiac output, and the estimated plasma volume status (ePVS) as a body fluid volume index. However, the usefulness of their c…
View article: Prediction of optical coherence tomography-detected calcified nodules using coronary computed tomography angiography
Prediction of optical coherence tomography-detected calcified nodules using coronary computed tomography angiography Open
View article: Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in Clinical Scenario 1
Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in Clinical Scenario 1 Open
Clinical scenario 1 (CS1) is acute heart failure (HF) characterized by transient systolic blood pressure (SBP) elevation and pulmonary congestion. Although it is managed by vasodilators, the molecular mechanism remains unclear. The sympath…
View article: sFlt-1 in Chronic Kidney Disease: Friend or Foe?
sFlt-1 in Chronic Kidney Disease: Friend or Foe? Open
Placental growth factor (PlGF) and its receptor, fms-like tyrosine kinase-1 (Flt-1), are important regulators involved in angiogenesis, atherogenesis, and inflammation. This review article focuses on the function of PlGF/Flt-1 signaling an…
View article: Mass Spectrometric Comparison of the Cardiac Globotriaosylceramide Profile in 5 Patients With Fabry’s Disease
Mass Spectrometric Comparison of the Cardiac Globotriaosylceramide Profile in 5 Patients With Fabry’s Disease Open
View article: Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation
Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation Open
Background: Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack o…