Kenji Schorpp
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View article: Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development Open
View article: Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action
Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action Open
Screening large molecule libraries against pathogenic bacteria is often challenged by a low hit rate due to limited uptake, underrepresentation of antibiotic structural motifs, and assays that do not resemble the infection conditions. To a…
View article: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism Open
The yeast glucose-induced degradation-deficient (GID) E3 ubiquitin ligase forms a suite of complexes with interchangeable receptors that selectively recruit N-terminal degron motifs of metabolic enzyme substrates. The orthologous higher eu…
View article: Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis Open
Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. Recent research has identified many regulators that induce or inhibit ferroptosis; yet, many regulatory processes and networks remain to be …
View article: CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting
CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting Open
Cell death, such as apoptosis and ferroptosis, play essential roles in the process of development, homeostasis, and pathogenesis of acute and chronic diseases. The increasing number of studies investigating cell death types in various dise…
View article: CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting
CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting Open
Cell death, such as apoptosis and ferroptosis, play essential roles in the process of development, homeostasis, and pathogenesis of acute and chronic diseases. The increasing number of studies investigating cell death types in various dise…
View article: Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis
Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis Open
Objective Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. The recent decade of research has uncovered many regulators driving ferroptosis as well as cellular gatekeepers preventing ferropt…
View article: Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma Open
View article: Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma Open
View article: Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity
Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity Open
Protein ubiquitination is an essential post‐translational modification that regulates a large number of cellular processes. This reaction is facilitated by the consecutive action of three central enzymes, i.e., E1 activating enzyme, E2 con…
View article: Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining Open
Determining cell death mechanisms occurring in patient and animal tissues is a longstanding goal that requires suitable biomarkers and accurate quantification. However, effective methods remain elusive. To develop more powerful and unbiase…
View article: Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development Open
View article: Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses Open
View article: Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection
Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection Open
View article: Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics Open
Innovative high-content screening platform identified N -(2-butoxyphenyl)-3-(phenyl)acrylamides as novel antifibrotics.
View article: Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 Open
View article: A drug screen with approved compounds identifies amlexanox as a novel Wnt/β‐catenin activator inducing lung epithelial organoid formation
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β‐catenin activator inducing lung epithelial organoid formation Open
Background and Purpose Emphysema is an incurable disease characterized by loss of lung tissue leading to impaired gas exchange. Wnt/β‐catenin signalling is reduced in emphysema, and exogenous activation of the pathway in experimental model…
View article: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Retinoic acid signaling is critical during the totipotency window in early mammalian development Open
View article: Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 Open
View article: Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses Open
S ummary The COVID-19 pandemic caused by SARS-CoV-2 has been socially and economically devastating. Despite an unprecedented research effort, effective therapeutics are still missing to limit severe disease and mortality. Using high-throug…
View article: Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism Open
View article: Studying OTUD6B-OTUB1 Protein–Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays
Studying OTUD6B-OTUB1 Protein–Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays Open
View article: Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice Open
Brown adipose tissue (BAT) plays an important role in the regulation of body weight and glucose homeostasis. Although increasing evidence supports white adipose tissue heterogeneity, little is known about heterogeneity within murine BAT. R…
View article: Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly Open
Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive splicing fa…
View article: Identification and characterization of distinct murine brown adipocyte lineages
Identification and characterization of distinct murine brown adipocyte lineages Open
Brown adipose tissue (BAT) plays an important role in the regulation of body weight and glucose homeostasis. While increasing evidence supports white adipose tissue heterogeneity, little is known about heterogeneity within murine BAT. Usin…
View article: Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2
Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2 Open
Background We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation induced papillary t…
View article: Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces Open
View article: Image-based high-content screening in drug discovery
Image-based high-content screening in drug discovery Open
View article: Transferrin Receptor Is a Specific Ferroptosis Marker
Transferrin Receptor Is a Specific Ferroptosis Marker Open
View article: Additional file 9 of Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2
Additional file 9 of Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2 Open
Additional file 9: SI Table 4. Ranking of network genes according to summarized centrality measure (see MM)