Kenji Tanimura
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View article: Pregnancy outcomes in women with anti-β2-glycoprotein I/human leukocyte antigen-DR autoantibodies receiving assisted reproductive technology: a prospective cohort study
Pregnancy outcomes in women with anti-β2-glycoprotein I/human leukocyte antigen-DR autoantibodies receiving assisted reproductive technology: a prospective cohort study Open
Objective This study aimed to assess whether anti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR autoantibodies are associated with pregnancy outcomes in women with infertility receiving assisted reproductive technology (ART) i…
View article: Prepregnancy obesity is an independent risk factor for neonatal vitamin K deficiency at birth
Prepregnancy obesity is an independent risk factor for neonatal vitamin K deficiency at birth Open
Maternal prepregnancy obesity is independently associated with an increased risk of VKD in neonates at birth. These findings suggest that targeted evaluation and vitamin K management strategies are warranted in pregnancies complicated by m…
View article: Changes in Neutrophil Count During Valganciclovir Therapy for Symptomatic Congenital Cytomegalovirus Infection
Changes in Neutrophil Count During Valganciclovir Therapy for Symptomatic Congenital Cytomegalovirus Infection Open
Background/Objectives: Neutropenia is a common adverse effect of oral valganciclovir (VGCV) treatment in infants with congenital cytomegalovirus infection (CCMVI), with an estimated prevalence of 20%. However, its clinical course and assoc…
View article: Plateletpheresis for treating essential thrombocythemia that developed during pregnancy: A case report
Plateletpheresis for treating essential thrombocythemia that developed during pregnancy: A case report Open
Plateletpheresis is useful for preventing hemorrhagic and thromboembolic complications at delivery in pregnant women with ET and severe thrombocythemia during the antepartum period.
View article: A Pregnant Woman with Primary Hyperparathyroidism Who Underwent Parathyroidectomy in the Second Trimester of Her Third Pregnancy: A Case Report.
A Pregnant Woman with Primary Hyperparathyroidism Who Underwent Parathyroidectomy in the Second Trimester of Her Third Pregnancy: A Case Report. Open
Primary hyperparathyroidism (PHPT) during pregnancy is rare, causing severe pregnancy complications. We report a pregnant woman with PHPT and a pregnancy complication history who underwent a single-gland parathyroidectomy during the second…
View article: Discrepancies in the Diagnosis of Congenital Toxoplasma gondii Infection Between B1 Gene Semi-Nested Polymerase Chain Reaction and Serological Analyses
Discrepancies in the Diagnosis of Congenital Toxoplasma gondii Infection Between B1 Gene Semi-Nested Polymerase Chain Reaction and Serological Analyses Open
Congenital Toxoplasma gondii (T. gondii) infection, which can be caused by a primary T. gondii infection during pregnancy, results in severe neurological sequelae in affected children. We have been conducting a prospective cohort study sin…
View article: Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study
Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study Open
Introduction Anti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR antibodies may be a risk factor for recurrent pregnancy loss (RPL). The therapeutic modality for women with RPL and anti-β2GPI/HLA-DR antibody positivity has not …
View article: Problems in screening for gestational diabetes mellitus by measurement of casual blood glucose levels at 24–28 gestational weeks
Problems in screening for gestational diabetes mellitus by measurement of casual blood glucose levels at 24–28 gestational weeks Open
Aims/Introduction This study aimed to evaluate the problems in screening for gestational diabetes mellitus (GDM) by casual blood glucose (CBG) measurements at 24–28 gestational weeks. Materials and Methods Overall, 763 pregnant women who u…
View article: HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report.
HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report. Open
Hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome is one of the most severe complications of hypertensive disorders of pregnancy. HELLP syndrome occurring before 22 gestational weeks (GWs) is extremely rare, …
View article: Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth
Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth Open
Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age…
View article: Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases
Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases Open
Background β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association between anti-β2GPI/HLA…
View article: Advantages of sensor‐augmented insulin pump therapy for pregnant women with type 1 diabetes mellitus
Advantages of sensor‐augmented insulin pump therapy for pregnant women with type 1 diabetes mellitus Open
Aims/Introduction To evaluate the efficacy of sensor‐augmented pump (SAP) for improving obstetric and neonatal outcomes among pregnant women with type 1 diabetes mellitus by comparing it with continuous subcutaneous insulin infusion plus s…
View article: Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases
Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases Open
Background. β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association between anti-β2GPⅠ/HL…
View article: Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes
Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes Open
Anti-β2-glycoprotein I/HLA-DR (anti-β2GPI/HLA-DR) antibody has been reported to be associated with antiphospholipid syndrome and recurrent pregnancy loss (RPL). We conducted a prospective multicenter cross-sectional study aimed at evaluati…
View article: POS1496 THE AUTOANTIBODY FOR BETA-2-GLYCOPROTEIN I COMPLEXED WITH HLA-DR LINKED TO ARTERIAL THROMBOSIS IN FEMALE PATIENTS WITH SYSTEMIC RHEUMATIC DISEASES
POS1496 THE AUTOANTIBODY FOR BETA-2-GLYCOPROTEIN I COMPLEXED WITH HLA-DR LINKED TO ARTERIAL THROMBOSIS IN FEMALE PATIENTS WITH SYSTEMIC RHEUMATIC DISEASES Open
View article: Fetal Ultrasound and Magnetic Resonance Imaging Abnormalities in Congenital Cytomegalovirus Infection Associated with and without Fetal Growth Restriction
Fetal Ultrasound and Magnetic Resonance Imaging Abnormalities in Congenital Cytomegalovirus Infection Associated with and without Fetal Growth Restriction Open
Congenital cytomegalovirus infection (cCMV) can cause fetal growth restriction (FGR) and severe sequelae in affected infants. Clinicians generally suspect cCMV based on multiple ultrasound (US) findings associated with cCMV. However, no st…
View article: Influence of UGT1A1 Genetic Variants on Free Bilirubin Levels in Japanese Newborns: A Preliminary Study
Influence of UGT1A1 Genetic Variants on Free Bilirubin Levels in Japanese Newborns: A Preliminary Study Open
Background: Free bilirubin (Bf) is a better marker than total serum bilirubin (TSB) for predicting bilirubin encephalopathy (BE). To date, two UGT1A1 genetic variants (rs4148323 and rs3064744) have been associated with neonatal hyperbiliru…
View article: Uterine endometrium microbiota and pregnancy outcome in women with recurrent pregnancy loss
Uterine endometrium microbiota and pregnancy outcome in women with recurrent pregnancy loss Open
View article: The Current Challenges in Developing Biological and Clinical Predictors of Congenital Cytomegalovirus Infection
The Current Challenges in Developing Biological and Clinical Predictors of Congenital Cytomegalovirus Infection Open
Congenital cytomegalovirus (CMV) infection may cause severe long-term sequelae. Recent studies have demonstrated that early antiviral therapy for infants with symptomatic congenital CMV (cCMV) infection may improve neurological outcomes; t…
View article: Change in Viral Load during Antiviral Therapy Is Not Useful for the Prediction of Hearing Dysfunction in Symptomatic Congenital Cytomegalovirus Infection
Change in Viral Load during Antiviral Therapy Is Not Useful for the Prediction of Hearing Dysfunction in Symptomatic Congenital Cytomegalovirus Infection Open
For symptomatic congenital cytomegalovirus infections (CCMVI), the usefulness of changes in viral load during valganciclovir (VGCV) treatment for the prediction of hearing dysfunction (HD) is unclear. To determine the utility of viral load…
View article: Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants
Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants Open
Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and morbidity. Oxidative stress is suggested to be involved in intrauterine growth restriction. This retrospective study aimed to evaluate the oxidative stress lev…
View article: Sudden fetal death with placental mesenchymal dysplasia complicated by placenta previa
Sudden fetal death with placental mesenchymal dysplasia complicated by placenta previa Open
Placental mesenchymal dysplasia (PMD) is a rare placental abnormality that is closely related to severe pregnancy complications. A 27‐year‐old woman with fetal growth restriction and placenta previa was referred to a university hospital at…
View article: Clinical factors associated with a placenta accreta spectrum
Clinical factors associated with a placenta accreta spectrum Open
View article: Efficacy of superselective transcatheter arterial embolization for intractable postpartum hemorrhage due to genital tract trauma after vaginal delivery
Efficacy of superselective transcatheter arterial embolization for intractable postpartum hemorrhage due to genital tract trauma after vaginal delivery Open
Purpose To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery. Methods We evaluated 27 patients who underwe…
View article: Abdominal compartment syndrome in a monochorionic‐triamniotic triplet pregnancy complicated by feto‐fetal transfusion syndrome
Abdominal compartment syndrome in a monochorionic‐triamniotic triplet pregnancy complicated by feto‐fetal transfusion syndrome Open
A 40‐year‐old primigravida woman with a monochorionic‐triamniotic (MT) triplet pregnancy was hospitalized due to threatened abortion at 16 gestational weeks. Polyhydramnios in two fetuses and oligohydramnios in the third supported a diagno…
View article: A Novel Autoantibody against β2-Glycoprotein I/HLA Class II Complexes in Antiphospholipid Syndrome
A Novel Autoantibody against β2-Glycoprotein I/HLA Class II Complexes in Antiphospholipid Syndrome Open
We have found that a novel autoantibody against β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA) class II complexes (anti-β2GPI/HLA-DR) is involved in the pathogenesis of antiphospholipid syndrome (APS). It was also found that many …
View article: The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease
The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease Open
Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway, which degrades heme into equimolar amounts of carbon monoxide, free iron, and biliverdin. Its inducible isoform, HO-1, has multiple protective functions, includ…
View article: Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease.
Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease. Open
Triiodothyronine (T3)-predominant Graves' disease is characterized by increased serum free T3 (FT3) levels after free thyroxine (FT4) levels become normal or even low during antithyroid drug treatment. We encountered a 34-year-old pregnant…
View article: Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks
Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks Open
To date, the difference in neurodevelopmental outcomes between late preterm infants (LPI) born at 34 and 35 gestational weeks (LPI-34 and LPI-35, respectively) has not been elucidated. This retrospective study aimed to evaluate neurodevelo…
View article: Changes in awareness and knowledge concerning mother-to-child infections among Japanese pregnant women between 2012 and 2018
Changes in awareness and knowledge concerning mother-to-child infections among Japanese pregnant women between 2012 and 2018 Open
This study aimed to investigate the long-term changes in awareness of and knowledge about mother-to-child infections across 6 years in Japan. A questionnaire survey was conducted at our facility from October 2012 to January 2018, and the s…