Explanipedia

New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets Open

Kenly Wuputra, Chia‐Chen Ku, Wen-Hung Hsu, Tusty‐Jiuan Hsieh, Yi‐Chun Tsai , et al. · 2025

The aryl hydrocarbon receptor (AHR) plays crucial roles in the control of stress, xenobiotic metabolism, inflammation, and cancer. However, information on the chromatin regulation of ligand-dependent AHR promoter activation is limit…

The AHR–NRF2–JDP2 gene battery: Ligand–induced AHR transcriptional activation Open

Kenly Wuputra, Wen-Hung Hsu, Chia‐Chen Ku, Ya-Han Yang, Kung‐Kai Kuo , et al. · 2025

Aryl hydrocarbon receptor (AHR) and nuclear factor-erythroid 2-related factor 2 (NRF2) can regulate a series of genes encoding the detoxifying phase I and II enzymes, via a signaling crosstalk known as the "AHR-NRF2 gene battery". The chro…

Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells Open

Chia‐Chen Ku, Jia-Bin Pan, Kenly Wuputra, Wen‐Li Hsu, Kohsuke Kato , et al. · 2024

The Jun dimerization protein ( Jdp2 ) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellul…

Vulnerability of Antioxidant Drug Therapies on Targeting the Nrf2-Trp53-Jdp2 Axis in Controlling Tumorigenesis Open

Ying‐Chu Lin, Chia‐Chen Ku, Kenly Wuputra, Deng-Chyang Wu, Kazunari K. Yokoyama · 2024

Control of oxidation/antioxidation homeostasis is important for cellular protective functions, and disruption of the antioxidation balance by exogenous and endogenous ligands can lead to profound pathological consequences of cancerous comm…

Vulnerability of antioxidant drug therapies on targeting Nrf2-Trp53-Jdp2 axis in controlling the tumorigenesis Open

Ying‐Chu Lin, Chia‐Chen Ku, Kenly Wuputra, Deng-Chyang Wu, Kazunari K. Yokoyama · 2024

Control of oxidation/antioxidation homeostasis is important for cellular protective functions, and disruption of the antioxidation balance by exogenous and endogenous ligands can lead to profound pathological consequences of cancerous comm…

Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells Open

Kazunari K. Yokoyama, Chia‐Chen Ku, Jia-Bin Pan, Kenly Wuputra, Wen‐Li Hsu , et al. · 2024

The Jun dimerization protein (Jdp2) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellular…

Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells Open

Ying‐Chu Lin, Chia‐Chen Ku, Kenly Wuputra, Chung‐Jung Liu, Deng‐Chyang Wu , et al. · 2024

The reprogramming of somatic cells to pluripotent stem cells has immense potential for use in regenerating or redeveloping tissues for transplantation, and the future application of this method is one of the most important research topics …

Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1 Open

Ying‐Chu Lin, Kenly Wuputra, Kohsuke Kato, Chia‐Chen Ku, Shigeo Saito , et al. · 2024

An understanding of the risk of gene deletion and mutation posed by endocrine-disrupting chemicals (EDCs) is necessary for the identification of etiological reagents for many human diseases. Therefore, the characterization of the genetic t…

Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model Open

Deng‐Chyang Wu, Chia‐Chen Ku, Jia-Bin Pan, Kenly Wuputra, Ya-Han Yang , et al. · 2023

Gastric cancer (GC) organoids are frequently used to examine cell proliferation and death as well as cancer development. Invasion/migration assay, xenotransplantation, and reactive oxygen species (ROS) production were used to examine the e…

Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Open

Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Chia‐Chen Ku, Jia-Bin Pan , et al. · 2023

Background Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to support cell survival…

Independent Signaling of Hepatoma Derived Growth Factor and Tumor Necrosis Factor-Alpha in Human Gastric Cancer Organoids Infected by Helicobacter pylori Open

Kenly Wuputra, Chia‐Chen Ku, Jia-Bin Pan, Chung‐Jung Liu, Kohsuke Kato , et al. · 2023

We prepared three-dimensional (3-D) organoids of human stomach cancers and examined the correlation between the tumorigenicity and cytotoxicity of Helicobacter pylori (H. pylori). In addition, the effects of hepatoma-derived growth factor …

Additional file 1 of Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Open

Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Chia‐Chen Ku, Jia-Bin Pan , et al. · 2023

Additional file 1: Supplementary Figure S1. Luciferase activity driven by the Cyp1b1 promoter in response to TCDD. Supplementary Figure S2. Characteristics of AhR protein expression and effects of Jdp2 on AhR expression. Supplementary Figu…

FOXM1-CD44 Signaling Is Critical for the Acquisition of Regorafenib Resistance in Human Liver Cancer Cells Open

Kenly Wuputra, Pi‐Jung Hsiao, Wen‐Tsan Chang, Po‐Hsuan Wu, Lin-Ann Chen , et al. · 2022

Regorafenib is a multikinase inhibitor that was approved by the US Food and Drug administration in 2017. Cancer stem cells (CSCs) are a small subset of cancer-initiating cells that are thought to contribute to therapeutic resistance. The f…

Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer Open

Kenly Wuputra, Chia‐Chen Ku, Jia-Bin Pan, Chung‐Jung Liu, Yi‐Chang Liu , et al. · 2022

Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric canc…

Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application Open

Shigeo Saito, Chia‐Chen Ku, Kenly Wuputra, Jia-Bin Pan, Chang‐Shen Lin , et al. · 2022

The use of biomarkers in cancer diagnosis, therapy, and prognosis has been highly effective over several decades. Studies of biomarkers in cancer patients pre- and post-treatment and during cancer progression have helped identify cancer st…

Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research Open

Chia‐Chen Ku, Kenly Wuputra, Jia-Bin Pan, Chia-Pei Li, Chung‐Jung Liu , et al. · 2022

There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for dev…

Translational models of 3-D organoids and cancer stem cells in gastric cancer research Open

Kenly Wuputra, Chia‐Chen Ku, Kohsuke Kato, Deng‐Chyang Wu, Shigeo Saito , et al. · 2021

Therapeutic Strategies Targeting Tumor Suppressor Genes in Pancreatic Cancer Open

Kung‐Kai Kuo, Pi‐Jung Hsiao, Wen‐Tsan Chang, Shih‐Chang Chuang, Ya-Han Yang , et al. · 2021

The high mortality of pancreatic cancer is attributed to the insidious progression of this disease, which results in a delayed diagnosis and advanced disease stage at diagnosis. More than 35% of patients with pancreatic cancer are in stage…

Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo Open

Chia‐Chen Ku, Kenly Wuputra, Kohsuke Kato, Jia-Bin Pan, Chia-Pei Li , et al. · 2021

Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts Open

Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Ya-Han Yang, Jia-Bin Pan , et al. · 2021

Redox control in the pathophysiology of influenza virus infection Open

Ker-Kong Chen, Moeko Minakuchi, Kenly Wuputra, Chia‐Chen Ku, Jia-Bin Pan , et al. · 2020

Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation Open

Chia‐Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen‐Hsin Lin, Jia-Bin Pan , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells Open

Kenly Wuputra, Chia‐Chen Ku, Deng‐Chyang Wu, Ying‐Chu Lin, Shigeo Saito , et al. · 2020

Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation Open

Chia‐Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen‐Hsin Lin, Jia-Bin Pan , et al. · 2020

Potential application of cell reprogramming techniques for cancer research Open

Shigeo Saito, Ying‐Chu Lin, Yukio Nakamura, Richard Eckner, Kenly Wuputra , et al. · 2018

Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16<sup>Ink4a</sup>‐pRb and Arf‐p53 pathways Open

Koji Nakade, Chang‐Shen Lin, Xiaoyu Chen, Ming‐Ho Tsai, Kenly Wuputra , et al. · 2017

The main regulators of replicative senescence in mice are p16 Ink4a and Arf, inhibitors of cell cycle progression. Jun dimerization protein 2 (JDP2)‐deficient mouse embryonic fibroblasts are resistant to replicative senescence through recr…

Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Open

Deng-Chyang Wu, Sophie S.W. Wang, Chung‐Jung Liu, Kenly Wuputra, Kohsuke Kato , et al. · 2017

Reprogramming of cancer cells into induced pluripotent stem cells (iPSCs) is a compelling idea for inhibiting oncogenesis, especially through modulation of homeobox proteins in this reprogramming process. We examined the role of various lo…

Application of Cancer Cell Reprogramming Technology to Human Cancer Research Open

Xiu-Yang Pan, Ming-Ho Tsai, Kenly Wuputra, Chia‐Chen Ku, Wen‐Hsin Lin , et al. · 2017

The cancer stem cell (CSC) hypothesis is an evolving concept of oncogenesis that has recently gained wide acceptance. By definition, CSCs exhibit continuous proliferation and self-renewal, and they have been proposed to play significant ro…

Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells Open

Kenly Wuputra, Chang‐Shen Lin, Ming-Ho Tsai, Chia‐Chen Ku, Wen‐Hsin Lin , et al. · 2017

The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identification that CSCs are responsible…

Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer Open

Kung‐Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying‐Chu Lin , et al. · 2016

The network of stemness genes and oncogenes in human patient-specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer. HepG2-derived induced pluripotent stem cell-like cells (HepG2-iPS-like cells) were gen…

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