Kenneth A. Skinner
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View article: Protein Sequencing with Single Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms
Protein Sequencing with Single Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms Open
Protein variants of the same gene─proteoforms─can have high molecular similarity yet exhibit different biological functions. Thus, the identification of unique peptides that unambiguously map to proteoforms can provide crucial biological i…
View article: Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6
Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6 Open
The vast complexity of the proteome currently overwhelms any single analytical technology in capturing the full spectrum of proteoform diversity. In this study, we evaluated the complementarity of two cutting-edge proteomic technologies—si…
View article: Protein sequencing with single amino acid resolution discerns peptides that discriminate tropomyosin proteoforms
Protein sequencing with single amino acid resolution discerns peptides that discriminate tropomyosin proteoforms Open
Protein variants of the same gene—proteoforms—can have high molecular similarity yet exhibit different biological functions. Thus, identifying unique peptides that unambiguously map to proteoforms can provide crucial biological insights. I…
View article: Efficient and Flexible Synthesis of New Photoactivatable Propofol Analogs
Efficient and Flexible Synthesis of New Photoactivatable Propofol Analogs Open
Propofol is a widely used general anesthetic, which acts by binding to and modulating several neuronal ion channels. We describe the synthesis of photoactivatable propofol analogs functionalized with an alkyne handle for bioorthogonal chem…
View article: Efficient and Flexible Synthesis of New Photoactivatable Propofol Analogs
Efficient and Flexible Synthesis of New Photoactivatable Propofol Analogs Open
Propofol is a widely used general anesthetic, which acts by binding to and modulating several neuronal ion channels. We describe the synthesis of photoactivatable propofol analogs functionalized with an alkyne handle for bioorthogonal chem…