Kenneth B. Adler
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View article: MARCKS protein is a potential target in a naturally occurring equine model of neutrophilic asthma
MARCKS protein is a potential target in a naturally occurring equine model of neutrophilic asthma Open
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Issue Information Open
View article: Peptide Inhibitors of MARCKS Suppress Endotoxin Induced Uveitis in Rats
Peptide Inhibitors of MARCKS Suppress Endotoxin Induced Uveitis in Rats Open
Purpose: To determine if inhibition of Myristoylated Alanine Rich C Kinase Substrate (MARCKS) protein, using novel MARCKS inhibitor peptides, will reduce the severity of endotoxin-induced uveitis (EIU) in rats. Methods:…
View article: Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain
Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain Open
View article: Peptide Inhibitors of MARCKS Reverse Endotoxin Induced Uveitis in Rats
Peptide Inhibitors of MARCKS Reverse Endotoxin Induced Uveitis in Rats Open
View article: An Inhaled MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) - Inhibitory Drug, BIO-11006, Elicited a Statistically-Significant Result (p= 0.02) in Overall Response Rate (ORR) After 3 Months Compared to Standard of Care Chemotherapy in a Phase 2 Trial of Late Stage Non Small Cell Lung Cancer (NSCLC)
An Inhaled MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) - Inhibitory Drug, BIO-11006, Elicited a Statistically-Significant Result (p= 0.02) in Overall Response Rate (ORR) After 3 Months Compared to Standard of Care Chemotherapy in a Phase 2 Trial of Late Stage Non Small Cell Lung Cancer (NSCLC) Open
View article: Deconstruct Lung Regenerative Medicine: From Cell Therapy to Secretome and Exosomes
Deconstruct Lung Regenerative Medicine: From Cell Therapy to Secretome and Exosomes Open
View article: A pre-investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis
A pre-investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis Open
Idiopathic pulmonary fibrosis is a lethal interstitial lung disease with unknown etiology, no cure, and few treatment options. Herein, a therapy option is presented that makes use of a heterogeneous population of lung cells, including prog…
View article: Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis Open
View article: MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network
MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network Open
View article: Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies
Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies Open
Here, for the first time, we demonstrated that direct culture and expansion of human lung progenitor cells from pulmonary tissues, acquired through a minimally invasive biopsy, is possible and straightforward with a three-dimensional cultu…
View article: Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies
Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies Open
BACKGROUND: Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source…
View article: An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice
An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice Open
Intratracheal instillation of bacterial LPS is a well-established model of acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Because the myristoylated alanine-rich C kinase substrate (MARCKS) protein is involved in…
View article: <scp>MARCKS</scp>‐dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
<span>MARCKS</span>‐dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging Open
Summary Ependymal cells ( EC s) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in EC s dec…