Kenneth Caidahl
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View article: Plasma proteins associated with cardiovascular disease in relation to lung function in SCAPIS
Plasma proteins associated with cardiovascular disease in relation to lung function in SCAPIS Open
Multiple CVD-associated proteins, mainly reflecting inflammatory and metabolic processes, were associated with reduced FEV1 and FVC, supporting a link between systemic inflammation, adipokine metabolism and impaired lung functio…
View article: Association of myocardial bridging and LAD length with Takotsubo syndrome: A MINOCA cross-sectional study
Association of myocardial bridging and LAD length with Takotsubo syndrome: A MINOCA cross-sectional study Open
This study found no significant association between MB or LAD length and the occurrence of TTS. These results suggest that structural variations in the LAD are unlikely to play a major role in the development of TTS, underscoring the impor…
View article: Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle
Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle Open
MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes. Associated with EVs, extracellular miR-136-3p may serve as a molecular messenger to communicate i…
View article: Tricuspid Aortic Valve Regurgitation Associates With Ascending Aortic Aneurysm Through Endothelial Activation and Lipoprotein Infiltration
Tricuspid Aortic Valve Regurgitation Associates With Ascending Aortic Aneurysm Through Endothelial Activation and Lipoprotein Infiltration Open
BACKGROUND: An abnormal accumulation of immune cells and inflammation has been described in ascending aortic aneurysm, but the factor driving disease initiation remains elusive. Interestingly, ascending aortic dilatation often occurs along…
View article: Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes
Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes Open
Aims/hypothesis The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes undertaking high-intensity interval exercise. Additionally, the association between regular eating be…
View article: Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
Associations between physical activity and CVD-related metabolomic and proteomic biomarkers Open
Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify as…
View article: Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization
Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization Open
Importance COVID-19 can lead to long-term cardiopulmonary symptoms and is associated with coronary microvascular dysfunction (CMD). However, long-term data on CMD after severe COVID-19 are lacking. Objective To investigate long-term left v…
View article: Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities
Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities Open
Funding Agencies|European Research Council [ERC-STG-2018-801965]; Swedish Research Council [VR 2019-01471, 2019-01236]; Swedish Heart-Lung Foundation [Hjart-Lungfonden] [20190505, 20200173]; Swedish Government [ALFGBG-991828]; Swedish coun…
View article: Elevated lipoprotein(a) and progression of aortic stenosis measured by Doppler echocardiography: A population‐based cohort study
Elevated lipoprotein(a) and progression of aortic stenosis measured by Doppler echocardiography: A population‐based cohort study Open
View article: Incremental value of coronary computed tomography angiography in addition to invasive coronary angiography in MINOCA
Incremental value of coronary computed tomography angiography in addition to invasive coronary angiography in MINOCA Open
Patients with the working diagnosis myocardial infarction with nonobstructive coronary arteries (MINOCA) have diverse underlying causes warranting further investigations. Despite the documented superiority of coronary computed tomography a…
View article: Safety of Shear Wave Elastography as Evidenced From Carotid Artery Strain and Strain Rate Induced by Acoustic Radiation Force Impulse and Arterial Pulsations
Safety of Shear Wave Elastography as Evidenced From Carotid Artery Strain and Strain Rate Induced by Acoustic Radiation Force Impulse and Arterial Pulsations Open
Our results indicate that arterial SWE does not expose the arterial wall to any higher strain or strain rate than is experienced during normal arterial pulsation. Further research is required to validate the results in arteries containing …
View article: Proteins associated with preserved ratio impaired spirometry
Proteins associated with preserved ratio impaired spirometry Open
Background Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanism…
View article: Kynurenines and aerobic exercise capacity in chronic kidney disease: A cross-sectional and longitudinal study
Kynurenines and aerobic exercise capacity in chronic kidney disease: A cross-sectional and longitudinal study Open
Background The causes of reduced aerobic exercise capacity (ExCap) in chronic kidney disease (CKD) are multifactorial, possibly involving the accumulation of tryptophan (TRP) metabolites such as kynurenine (KYN) and kynurenic acid (KYNA), …
View article: Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization
Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization Open
Background Coronavirus disease 2019 (COVID-19) can lead to long-term cardiopulmonary symptoms and is associated to coronary microvascular dysfunction (CMD). However, long-term data on CMD following severe COVID-19 are lacking. Objective To…
View article: Chronic Airflow Limitation, Emphysema, and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-aged Population
Chronic Airflow Limitation, Emphysema, and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-aged Population Open
Rationale: Chronic obstructive pulmonary disease (COPD) includes respiratory symptoms and chronic airflow limitation (CAL). In some cases, emphysema and impaired diffusing capacity of the lung for carbon monoxide (DlCO) a…
View article: Lipoprotein retention and inflammation due to regurgitant blood flow as part of the natural history of degenerative ascending aortic aneurysms
Lipoprotein retention and inflammation due to regurgitant blood flow as part of the natural history of degenerative ascending aortic aneurysms Open
BACKGROUND An abnormal accumulation of immune cells and a disrupted lipoprotein metabolism has previously been described as part of the pathogenesis of ascending aortic aneurysm in patients with tricuspid aortic valves. The factor driving …
View article: Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50–64 Years
Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50–64 Years Open
Rationale: Knowledge regarding the prevalence and shared and unique characteristics of the restrictive spirometric pattern (RSP) and preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with p…
View article: Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women Open
View article: Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study
Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study Open
Objectives The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). Design and setting A prospec…
View article: Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life
Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life Open
Background Arterial stiffening and increased intima‐media thickness can be seen as early as childhood and are associated with increased risk of cardiovascular events in adult life. The authors hypothesized that exposure to prenatal smokele…
View article: Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications Open
View article: Editors’ highlight picks from 2023 in <i>EHJ Open</i>
Editors’ highlight picks from 2023 in <i>EHJ Open</i> Open
peer reviewed
View article: Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M Open
The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, and the role in mediating beneficial effects of exercise. We studied the adipose tissue …
View article: Prognostic utility and characterization of left ventricular hypertrophy using global thickness
Prognostic utility and characterization of left ventricular hypertrophy using global thickness Open
View article: A multi-pulse ultrasound technique for imaging of thick-shelled microbubbles demonstrated in vitro and in vivo
A multi-pulse ultrasound technique for imaging of thick-shelled microbubbles demonstrated in vitro and in vivo Open
Contrast enhanced ultrasound is a powerful diagnostic tool and ultrasound contrast media are based on microbubbles (MBs). The use of MBs in drug delivery applications and molecular imaging is a relatively new field of research which has ga…
View article: Health-related quality-of-life up to one year after myocardial infarction with non-obstructive coronary arteries
Health-related quality-of-life up to one year after myocardial infarction with non-obstructive coronary arteries Open
Aims Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) are a heterogenous group and previous studies indicate a decreased Health-related quality-of-life (HRQoL) compared with patients with myocardial infar…
View article: Cardiovascular magnetic resonance imaging after normal echocardiography in myocardial infarction with nonobstructed coronary arteries
Cardiovascular magnetic resonance imaging after normal echocardiography in myocardial infarction with nonobstructed coronary arteries Open
Background In patients with myocardial infarction with nonobstructive coronary arteries (MINOCA), cardiovascular magnetic resonance imaging (CMR) can often establish a causal diagnosis. It is unknown if CMR is warranted in patients with no…
View article: Left ventricular mass and global wall thickness – prognostic utility and characterization of left ventricular hypertrophy
Left ventricular mass and global wall thickness – prognostic utility and characterization of left ventricular hypertrophy Open
AIMS Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, which is associated with morbidity and mortality. Several measures related to LV wall thickness exist, with uncertain relative prognostic stren…
View article: Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes Open
Mechanistic insights into the molecular events by which exercise enhances the skeletal muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here, we unravel a fundamental role for exercise-responsive cytokines ( ex…
View article: Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients – A randomized crossover trial
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients – A randomized crossover trial Open
We provide a comprehensive analysis of a multi-tissue metabolomic and skeletal muscle proteomic responses to training at different times of the day in men with type 2 diabetes. Increased circulating lipids and changes in adipose tissue lip…