Kenneth D. Burman
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View article: Differentiated Thyroid Cancer Is Associated With Sex-specific Immune Response
Differentiated Thyroid Cancer Is Associated With Sex-specific Immune Response Open
Background Thyroid cancer (TC) exhibits sex-based disparities in incidence, progression, and outcomes, with women of reproductive age exhibiting more favorable prognoses than men. This study investigates sex differences in immune cell dyna…
View article: SUN-337 Aggressive Papillary Thyroid Carcinoma with Miliary Pulmonary Metastases and Unconventional Treatment Adaptations
SUN-337 Aggressive Papillary Thyroid Carcinoma with Miliary Pulmonary Metastases and Unconventional Treatment Adaptations Open
Disclosure: J.B. Ding: None. R. Pristoop: None. M.L. Pierce: None. A. Holley: None. O.O. Tannous: None. I.G. Veytsman: None. A. Omogbehin: None. D. Moreno Watashi: None. K.D. Burman: None. Introduction or Background: Papillary thyroid carc…
View article: SAT-386 Challenges of Management of Thyroid Storm in the Setting of Acute Liver Failure
SAT-386 Challenges of Management of Thyroid Storm in the Setting of Acute Liver Failure Open
Disclosure: A. Suresh: None. W. Kuenstner: None. K.D. Burman: None. Introduction: The management of thyroid storm involves thioamides, beta-blockers, inorganic iodine, and corticosteroids. However, downstream complications such as heart fa…
View article: PD-L1 Expression Varies in Thyroid Cancer Types and Is Associated with Decreased Progression Free Survival (PFS) in Patients with Anaplastic Thyroid Cancer
PD-L1 Expression Varies in Thyroid Cancer Types and Is Associated with Decreased Progression Free Survival (PFS) in Patients with Anaplastic Thyroid Cancer Open
Background: Thyroid cancer (TC) remains a significant clinical challenge worldwide, with a subset of patients facing aggressive disease progression and therapeutic resistance. Immune checkpoint inhibitors targeting programmed death-ligand …
View article: NTRK Fusion as an Acquired Mechanism of Resistance to Selpercatinib in RET Positive Thyroid Cancer
NTRK Fusion as an Acquired Mechanism of Resistance to Selpercatinib in RET Positive Thyroid Cancer Open
Background: Rearrangement during Transfection (RET) proto-oncogene is involved in the pathogenesis of various thyroid cancer subtypes and drugs that block the RET tyrosine kinase pathways are used in the management of locally advanced and …
View article: Association of Free Thyroxine With Progression-Free Survival in Intermediate and High-Risk Differentiated Thyroid Cancer
Association of Free Thyroxine With Progression-Free Survival in Intermediate and High-Risk Differentiated Thyroid Cancer Open
Context Supraphysiologic T4 doses are used in intermediate- and high-risk patients with differentiated thyroid cancer (IR/HR-DTC) to suppress tumor progression by TSH. However, preclinical data suggest that T4 can also act as a growth stim…
View article: Influence of Thyroglobulin Autoantibodies on Thyroglobulin Levels Measured by Different Methodologies: IMA, LC-MS/MS, and RIA
Influence of Thyroglobulin Autoantibodies on Thyroglobulin Levels Measured by Different Methodologies: IMA, LC-MS/MS, and RIA Open
Context Serum thyroglobulin (Tg) measured by immunometric assay (IMA) is prone to underestimation due to Tg autoantibody (TgAb) interference, often prompting reflex Tg measurement by liquid chromatography/tandem mass spectrometry (MS) or r…
View article: Sex-Specific Expression of Histone Lysine Demethylases (KDMs) in Thyroid Cancer
Sex-Specific Expression of Histone Lysine Demethylases (KDMs) in Thyroid Cancer Open
Background: The incidence of thyroid cancer in women is 3–4-fold higher than in men. To characterize sex-specific molecular alterations in thyroid cancer, we examined the expression of sex-biased genes in normal thyroids and thyroid tumors…
View article: A Rare Case of Persistent Multifocal Cribriform-Morular Thyroid Carcinoma
A Rare Case of Persistent Multifocal Cribriform-Morular Thyroid Carcinoma Open
View article: Efficacy of Levothyroxine Sodium Soft Gelatin Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors: An Open-Label Study
Efficacy of Levothyroxine Sodium Soft Gelatin Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors: An Open-Label Study Open
Background: Treatment with proton pump inhibitors (PPIs) and antacids affects the gastrointestinal absorption of levothyroxine sodium (LT4) tablets. Patients with hypothyroidism taking LT4 and PPIs or antacids, thus, require …
View article: SAT519 Association of Free Thyroxine Level With Survival Outcome In Patients With Intermediate And High-Risk Differentiated Thyroid Cancer
SAT519 Association of Free Thyroxine Level With Survival Outcome In Patients With Intermediate And High-Risk Differentiated Thyroid Cancer Open
Disclosure: R. Ghosh: None. S. Auh: None. S. Gubbi: None. P. Veeraraghavan: None. C. Cochran: None. L. Shobab: None. K.D. Burman: None. L. Wartofsky: None. J. Klubo-Gwiezdzinska: None. Background Total thyroidectomy followed by radioiodine…
View article: Characteristics, staging and outcomes of differentiated thyroid cancer in patients with and without Graves’ disease
Characteristics, staging and outcomes of differentiated thyroid cancer in patients with and without Graves’ disease Open
We found patients with GD had smaller tumor size, early-stage DTC when compared to patients without GD and potentially favorable prognosis. More data is needed to understand whether this is due to pathogenesis like Graves antibodies promot…
View article: Table of Contents (4 pgs)
Table of Contents (4 pgs) Open
View article: Response to Letter to the Editor from Zandee and Links: “Metastatic Differentiated Thyroid Cancer Survival Is Unaffected by Mode of Preparation for 131I Administration”
Response to Letter to the Editor from Zandee and Links: “Metastatic Differentiated Thyroid Cancer Survival Is Unaffected by Mode of Preparation for 131I Administration” Open
View article: RF23 | PSAT365 An Open-Label Therapeutic Efficacy Study of Tirosint (Levothyroxine Sodium) Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors
RF23 | PSAT365 An Open-Label Therapeutic Efficacy Study of Tirosint (Levothyroxine Sodium) Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors Open
Levothyroxine sodium (LT4) absorption is known to be affected by proton pump inhibitors (PPIs). Normal gastric acid secretion is important for the subsequent intestinal absorption of LT4. A reduced gastric acidity may diminish the dissolut…
View article: Metastatic Differentiated Thyroid Cancer Survival Is Unaffected by Mode of Preparation for 131I Administration
Metastatic Differentiated Thyroid Cancer Survival Is Unaffected by Mode of Preparation for 131I Administration Open
Context Recombinant human thyrotropin (rhTSH) is currently not Food and Drug Administration approved for the treatment of high-risk patients with differentiated thyroid cancer (DTC). Objective The goal of our study was to compare the outco…
View article: Do Ultrasound Patterns and Clinical Parameters Inform the Probability of Thyroid Cancer Predicted by Molecular Testing in Nodules with Indeterminate Cytology?
Do Ultrasound Patterns and Clinical Parameters Inform the Probability of Thyroid Cancer Predicted by Molecular Testing in Nodules with Indeterminate Cytology? Open
Background: Molecular testing (MT) is commonly used to refine cancer probability in thyroid nodules with indeterminate cytology. Whether or not ultrasound (US) patterns and clinical parameters can further inform the risk of t…
View article: Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin
Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin Open
Background: Biotin has been reported to interfere with several commonly used laboratory assays resulting in misleading values and possible erroneous diagnosis and treatment. This report describes a prospective study of possib…
View article: Resolution of hyperthyroidism and thyroid antibodies following struma ovarii resection: an uncommon entity
Resolution of hyperthyroidism and thyroid antibodies following struma ovarii resection: an uncommon entity Open
We report a case of 34-year-old clinically asymptomatic woman who had been followed for 6 years for hyperthyroidism with thyroid stimulating hormone <0.006 uIU/mL, free T4 1.98 ng/mL, free T3 5.3 pg/mL, elevated thyroid stimulating immunog…
View article: Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ?
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? Open
Management of metastatic radioiodine refractory differentiated thyroid cancer (DTC) can be a therapeutic challenge. Generally, little is known about the paired molecular profile of the primary tumor and the metastases and whether they harb…
View article: Response to Letter to the Editor from Sukor et al.: “Evaluation and Treatment of Amiodarone-induced Thyroid Disorders”
Response to Letter to the Editor from Sukor et al.: “Evaluation and Treatment of Amiodarone-induced Thyroid Disorders” Open
View article: Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses
Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses Open
BACKGROUND: Immune checkpoint inhibitors (ICPi) cause various immune-related adverse events (irAE) with thyroid dysfunction as a commonly reported abnormality. There is increasing evidence showing positive association with development of i…
View article: Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland
Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland Open
View article: Cytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic Target for the Treatment of Medullary Thyroid Cancer
Cytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic Target for the Treatment of Medullary Thyroid Cancer Open
The nuclear-encoded subunit 4 of cytochrome c oxidase (COX4) plays a role in regulation of oxidative phosphorylation and contributes to cancer progression. We sought to determine the role of COX4 in differentiated (DTC) and medullary (MTC)…
View article: Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy
Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy Open
The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the BRAFV600E mutations (cfBRAFV600E) in …
View article: 30 mCi exploratory scan for two-step dosimetric 131I therapy in differentiated thyroid cancer patients: A novel approach and case report
30 mCi exploratory scan for two-step dosimetric 131I therapy in differentiated thyroid cancer patients: A novel approach and case report Open
Differentiated thyroid cancer patients with significantly elevated or rapidly rising serum thyroglobulin (Tg) levels and negative diagnostic radioiodine scans (DxScan) often present a therapeutic dilemma in deciding whether or not to admin…
View article: MON-LB79 Do Ultrasound Patterns and Clinical Parameters Modify the Probability of Thyroid Cancer Predicted by Molecular Testing in Thyroid Nodules With Indeterminate Cytology?
MON-LB79 Do Ultrasound Patterns and Clinical Parameters Modify the Probability of Thyroid Cancer Predicted by Molecular Testing in Thyroid Nodules With Indeterminate Cytology? Open
Background: Molecular testing (MT) is commonly used to refine cancer probability in thyroid nodules with indeterminate cytology. Whether or not ultrasound (US) patterns and clinical parameters can further modify the risk of cancer in nodul…
View article: MON-514 Detection of RAS Mutations and RET/PTC Fusions in Thyroid Cancer Using Microfluidic Digital PCR
MON-514 Detection of RAS Mutations and RET/PTC Fusions in Thyroid Cancer Using Microfluidic Digital PCR Open
Background: The identification of somatic mutations and gene fusions is crucial for guiding therapeutic decisions in patients with thyroid cancer. Microfluidic digital PCR is currently considered as a technique of choice for highly sensiti…
View article: Assessment of Thyroid Function in Patients With Alkaptonuria
Assessment of Thyroid Function in Patients With Alkaptonuria Open
The high prevalence of primary hypothyroidism noted in patients with alkaptonuria in this study suggests that serial screening in this population should be considered and prioritized.
View article: Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous <i>SBP2</i> (<i>SECISBP2</i>) Mutations
Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous <i>SBP2</i> (<i>SECISBP2</i>) Mutations Open
Context Selenocysteine insertion sequence binding protein 2 (SECISBP2, SBP2) is an essential factor for selenoprotein synthesis. Individuals with SBP2 defects have characteristic thyroid function test (TFT) abnormalities resulting from def…