Kenneth D. Candido
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View article: Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology
Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology Open
The most common cause of radicular leg pain is lumbar disc herniation (LDH). LDH occurs when the central disc material, predominantly the nucleus pulposus, is displaced beyond the margins of the disc, compressing the spinal nerve roots and…
View article: The Effect of Local Skin Precooling on Alleviating Injection Site Pain in Patients With Androgenetic Alopecia Receiving a Scalp Nerve Block
The Effect of Local Skin Precooling on Alleviating Injection Site Pain in Patients With Androgenetic Alopecia Receiving a Scalp Nerve Block Open
BACKGROUND: Scalp platelet-rich plasma (PRP) mesotherapy is commonly used to increase hair density and improve scalp health in patients with androgenetic alopecia. While PRP therapy is favored for its lower risk of adverse effects and redu…
View article: In Memoriam: Dr. Jorge Antonia ("Tony") Aldrete 1937-2025
In Memoriam: Dr. Jorge Antonia ("Tony") Aldrete 1937-2025 Open
Professor Jorge Antonio “Tony” Aldrete, 1937-2025, was a pioneer in anesthesiology and pain medicine, having led a distinguished career spanning more than 5 decades. Originally interested in creating pathways for the first liver transplant…
View article: Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation
Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation Open
Study Design. An exploratory analysis of a randomized, double-blind, sham-controlled, phase three study. Objective. To evaluate the impact of SI-6603 (condoliase) on health-related quality of life (HRQoL)-related outcomes in patients with …
View article: Exosome-rich mesenchymal stem cell secretome improves strength in patients with amyotrophic lateral sclerosis, Kennedy disease, congenital myasthenic syndrome and Lewy body dementia
Exosome-rich mesenchymal stem cell secretome improves strength in patients with amyotrophic lateral sclerosis, Kennedy disease, congenital myasthenic syndrome and Lewy body dementia Open
Intranasally-instilled AlloEx Exosomes® are completely safe, attenuate progression, and improve strength in ALS, Kennedy Disease, CMS, and LBD.
View article: A phase 3, randomized, double-blind, sham-controlled trial of SI-6603 (condoliase) in patients with radicular leg pain associated with lumbar disc herniation
A phase 3, randomized, double-blind, sham-controlled trial of SI-6603 (condoliase) in patients with radicular leg pain associated with lumbar disc herniation Open
Condoliase met its primary endpoint of significantly improving radicular leg pain at Week 13 and was generally well tolerated in patients with LDH. Chemonucleolysis with condoliase has the potential to provide a less invasive treatment opt…
View article: Surgical treatment of refractory low back pain using implanted BurstDR spinal cord stimulation (SCS) in a cohort of patients without options for corrective surgery: Findings and results from the DISTINCT study, a prospective randomized multi-center-controlled trial
Surgical treatment of refractory low back pain using implanted BurstDR spinal cord stimulation (SCS) in a cohort of patients without options for corrective surgery: Findings and results from the DISTINCT study, a prospective randomized multi-center-controlled trial Open
View article: A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain Open
Epidural steroid injections are used to treat lumbosacral radicular pain. However, there are no Food and Drug Administration–approved corticosteroids for lumbosacral radicular pain and all currently available injectable corticosteroids car…
View article: Treatment of Refractory Low Back Pain Using Passive Recharge Burst in Patients Without Options for Corrective Surgery: Findings and Results From the DISTINCT Study, a Prospective Randomized Multicenter Controlled Trial
Treatment of Refractory Low Back Pain Using Passive Recharge Burst in Patients Without Options for Corrective Surgery: Findings and Results From the DISTINCT Study, a Prospective Randomized Multicenter Controlled Trial Open
View article: The unconventional successful use of epinephrine for the intraoperative management of patient with preoperatively diagnosed Takotsubo syndrome
The unconventional successful use of epinephrine for the intraoperative management of patient with preoperatively diagnosed Takotsubo syndrome Open
View article: Long-term Safety of Spinal Cord Stimulation Systems in A Prospective, Global Registry of Patients With Chronic Pain
Long-term Safety of Spinal Cord Stimulation Systems in A Prospective, Global Registry of Patients With Chronic Pain Open
Aim: The availability of long-term (>2 years) safety outcomes of spinal cord stimulation (SCS) remains limited. We evaluated safety in a global SCS registry for chronic pain. Methods: Participants were prospectively enrolled …
View article: Circadian pain patterns in human pain conditions – A systematic review
Circadian pain patterns in human pain conditions – A systematic review Open
Background Chronobiology is the science of how physiological processes in the body follow a pattern of time. Pain has been shown to follow a circadian rhythm, with different types of pain having variable expression along this rhythm. Objec…
View article: Parasagittal Approach of Epidural Steroid Injection as a Treatment for Chronic Low Back Pain: A Systematic Review and Meta-Analysis
Parasagittal Approach of Epidural Steroid Injection as a Treatment for Chronic Low Back Pain: A Systematic Review and Meta-Analysis Open
Background: Epidural steroid injection (ESI) has proven benefits in controlling chronic low back pain and can be performed via the midline interlaminar (MIL) or transforaminal (TF) approach. A modified interlaminar approach, the parasagitt…
View article: Low back pain
Low back pain Open
View article: Combination of the T7 Unilateral Erector Spinae Plane Block and T10 Bilateral Retrolaminar Blocks in a Patient with Multiple Rib Fractures on the Right and T10–12 Vertebral Compression Fractures: A Case Report
Combination of the T7 Unilateral Erector Spinae Plane Block and T10 Bilateral Retrolaminar Blocks in a Patient with Multiple Rib Fractures on the Right and T10–12 Vertebral Compression Fractures: A Case Report Open
Multiple vertebral compression and rib fractures in elderly patients with pre-existing chronic obstructive pulmonary disease is a common scenario associated with significant morbidity and mortality. Severe pain prevents normal ventilation …
View article: A novel checklist for anesthesia in neurosurgical cases
A novel checklist for anesthesia in neurosurgical cases Open
Throughout their training, anesthesiology residents are exposed to a variety of surgical subspecialties, many of which have specific anesthetic considerations. According to the Accreditation Council for Graduate Medical Education requireme…
View article: The Successful Use of Left-Sided Stellate Ganglion Block in Patients That Fail to Respond to Right-Sided Stellate Ganglion Block for the Treatment of Post-Traumatic Stress Disorder Symptoms: A Retrospective Analysis of 205 Patients
The Successful Use of Left-Sided Stellate Ganglion Block in Patients That Fail to Respond to Right-Sided Stellate Ganglion Block for the Treatment of Post-Traumatic Stress Disorder Symptoms: A Retrospective Analysis of 205 Patients Open
View article: Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia
Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia Open
BACKGROUND: Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to insulin. IR has been associated with multiple conditions, including chronic pain. Fibromyalgia (FM) is one of the common generalized…
View article: Herbal Medicine for Pain Management: Efficacy and Drug Interactions
Herbal Medicine for Pain Management: Efficacy and Drug Interactions Open
Complementary and alternative medicines such as herbal medicines are not currently part of the conventional medical system. As the popularity of and global market for herbal medicine grows among all age groups, with supporting scientific d…
View article: Interventionist performs a “sham” lumbar microdiscectomy: Should interventionalists be performing spinal surgery?
Interventionist performs a “sham” lumbar microdiscectomy: Should interventionalists be performing spinal surgery? Open
Background: Neurosurgeons and orthopedists, who have received specific training, should be the ones performing spinal surgery. Here, we present a case in which spinal surgeons secondarily (e.g., 6 months later) found that a patient’s first…
View article: Innovative overhead transparent plastic barrier with powered suction technique intended to limit coronavirus disease 2019 aerosols spread during fiber-optic intubation and throughout the surgery
Innovative overhead transparent plastic barrier with powered suction technique intended to limit coronavirus disease 2019 aerosols spread during fiber-optic intubation and throughout the surgery Open
Background: In the context of the current coronavirus pandemic, we propose an inexpensive, innovative overhead transparent plastic barrier with powered suction (OTPBPS) technique using materials that are ubiquitous in the hospital, easy to…
View article: Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?
Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain? Open
Etiology of back pain is multifactorial and not completely understood, and for the majority of people who suffer from chronic low back pain (cLBP), the precise cause cannot be determined. We know that back pain is somewhat heritable, chron…
View article: Physiologically Difficult Airway in the Patient with Severe Hypotension and Metabolic Acidosis
Physiologically Difficult Airway in the Patient with Severe Hypotension and Metabolic Acidosis Open
The expertise to recognize and manage the difficult airway is essential in anesthesiology. Conventionally, this refers to anatomical concerns causing difficulties with facemask ventilation and/or with tracheal intubation. Severe derangemen…
View article: Management of CRPS secondary to preganglionic C8 nerve root avulsion: A case report and literature review
Management of CRPS secondary to preganglionic C8 nerve root avulsion: A case report and literature review Open
Background: Cervical nerve root avulsion is a well-documented result of high-velocity motor vehicle accidents (MVAs). In up to 21% of cases, preganglionic cervical root avulsion can result in a complex regional pain syndrome (CRPS) impacti…
View article: The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents
The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents Open
Tryptophan (TRP) is an essential, aromatic amino acid catabolized by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) enzymes into kynurenine. The IDO enzyme is expressed in peripheral tissues and the central nervous …
View article: Improved Psychosocial and Functional Outcomes and Reduced Opioid Usage Following Burst Spinal Cord Stimulation
Improved Psychosocial and Functional Outcomes and Reduced Opioid Usage Following Burst Spinal Cord Stimulation Open
View article: Recent decline in the use of invasive neurocritical care monitoring for traumatic brain injury: A case report
Recent decline in the use of invasive neurocritical care monitoring for traumatic brain injury: A case report Open
Background: In this article, we discuss the dramatic decline in the utilization of invasive cranial monitoring of patients with traumatic brain injury (TBI). Case Description: A 52-year-old male presented with a severe TBI following a moto…
View article: SNI case of the week: Initial concomitant use of gabapentin, clonidine, and prednisone may enhance suicidal ideation: A case report
SNI case of the week: Initial concomitant use of gabapentin, clonidine, and prednisone may enhance suicidal ideation: A case report Open
Background: Suicide cases are the end product of a combination of biological, clinical, psychological, social, and cultural risk/protective factors, and attempts to remain unpredictable. Case Description: A 43-year-old male presented to th…
View article: Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers
Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers Open
Introduction: Neuropathic pain is a chronic condition that significantly affects the quality of life of millions of people globally. Most of the pharmacologic treatments currently in use demonstrate modest efficacy and over half of …