Explanipedia

Angiotensin receptors in GtoPdb v.2025.3 Open

Wayne Alexander, Sadashiva S. Karnik, Jacqueline Kemp, Luxmichan Laishram, Walter G. Thomas , et al. · 2025

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The octapeptide angiotensin …

Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue Open

Filip Hanak, J Swanson, Krzysztof Felczak, Kenneth E. Bernstein, Swati S. More , et al. · 2025

Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin peptides in the periphery, and can also regulate endogenous opioid signaling by degrading enkephalin peptides in the brain. ACE has two catalytic domains,…

Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme Open

Delia Oosthuizen, Tariq Ganief, Kenneth E. Bernstein, Edward D. Sturrock · 2024

Angiotensin converting enzyme (ACE) exerts strong modulation of myeloid cell function independently of its cardiovascular arm. The success of the ACE-overexpressing murine macrophage model, ACE 10/10, in treating microbial infections and c…

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Open

S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair Mathie , et al. · 2023

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…

The effects of enhancing angiotensin converting enzyme in myelomonocytes on ameliorating Alzheimer’s-related disease and preserving cognition Open

Ron Danziger, Dieu‐Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn , et al. · 2023

This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer’s disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ 4…

Angiotensin receptors in GtoPdb v.2023.1 Open

Wayne Alexander, Kenneth E. Bernstein, Kevin Catt, Marc de Gasparo, Khuraijam Dhanachandra Singh , et al. · 2023

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin …

Knockout of ACE-N facilitates improved cardiac function after myocardial infarction Open

Hamid Suhail, Hongmei Peng, Jiang Xu, Hani N. Sabbah, Khalid Matrougui , et al. · 2022

Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACE-N). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. …

LOCL-11 EGFR-MUTATED NON-SMALL CELL LUNG CANCER (NSCLC) LEPTOMENINGEAL DISEASE (LMD) IN A LARGE STEREOTACTIC RADIOSURGERY PATIENT COHORT: INCIDENCE AND OUTCOME Open

Reed Mullen, Bernadine R. Donahue, Juan F. Álzate, Joshua S. Silverman, Assaf Berger , et al. · 2022

AIM Patients with EGFR-mutated NSCLC brain metastases (BM) treated with targeted agents +/- radiosurgery (SRS) have increasing life expectancies. Systemic treatment may become less effective in preventing CNS progression as survival is pro…

Single-cell profiling identifies ACE+granuloma macrophages as a non-permissive niche for intracellular bacteria during persistentSalmonellainfection Open

Trung H.M. Pham, Yuan Xue, Susan Brewer, Kenneth E. Bernstein, Stephen R. Quake , et al. · 2022

Macrophages mediate key antimicrobial responses against intracellular bacterial pathogens, such as Salmonella enterica . Yet, they can also act as a permissive niche for these pathogens to persist in infected tissues within granulomas, whi…

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors Open

S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair Mathie , et al. · 2021

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasi…

Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron Open

Jonathan W. Nelson, Alicia A. McDonough, Zhidan Xiang, Donna L. Ralph, Joshua A. Robertson , et al. · 2021

Our study defines a novel role for proximal tubule angiotensin receptors in regulating the abundance of Na + transporters throughout the nephron, thereby contributing to the integrated control of fluid balance in vivo.

Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO‐mediated mechanisms Open

Fernando P. Dominici, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, D. Quiroga , et al. · 2020

Background and Purpose The AT 2 receptor plays a role in metabolism by opposing the actions triggered by the AT 1 receptors. Activation of AT 2 receptors has been shown to enhance insulin sensitivity in both normal and insulin resistance a…

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors Open

S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair Mathie , et al. · 2019

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacolog…

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease Open

Maya Koronyo‐Hamaoui, Julia Sheyn, Eric Y. Hayden, Songlin Li, Dieu‐Trang Fuchs , et al. · 2019

Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral myelomonocytes (ACE10 model) substantially diminished Alzheimer’s-like disease in double-tran…

Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open

Wayne Alexander, Kenneth E. Bernstein, Kevin Catt, Marc de Gasparo, Khuraijam Dhanachandra Singh , et al. · 2019

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [61, 152]), which have around 30% sequence similarity. The decapeptide angiotensin …

Angiotensin‐converting enzyme inhibitor works as a scar formation inhibitor by down‐regulating Smad and TGF‐β‐activated kinase 1 (TAK1) pathways in mice Open

Wei‐Qiang Tan, Qing‐Qing Fang, Xiao Z. Shen, Jorge F. Giani, Tuantuan Zhao , et al. · 2018

Background and Purpose Angiotensin‐converting enzyme (ACE), an important part of the renin‐angiotensin system, is implicated in stimulating the fibrotic processes in the heart, lung, liver and kidney, while an ACE inhibitor (ACEI) promotes…

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis Open

Philip O’Reilly, Qiang Ding, Samia Akthar, Guoqiang Cai, Kristopher R. Genschmer , et al. · 2017

The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A4 hydrolase (LT…

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation Open

You Li, Xiao Z. Shen, Liang Li, Tuantuan Zhao, Kenneth E. Bernstein , et al. · 2017

Background and Purpose— Hypertension is the major risk factor for stroke. Recent work unveiled that hypertension is associated with chronic neuroinflammation; microglia are the major players in neuroinflammation, and the activated microgli…

Angiotensin-converting enzyme affects the presentation of MHC class II antigens Open

Tuantuan Zhao, Kenneth E. Bernstein, Jianmin Fang, Xiao Z. Shen · 2017

Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity Open

Jorge F. Giani, Masahiro Eriguchi, Ellen A. Bernstein, Makoto Katsumata, Xiao Z. Shen , et al. · 2016

Immune activation caused by vascular oxidation promotes fibrosis and hypertension Open

Jing Wu, Mohamed A. Saleh, Annet Kirabo, Hana A. Itani, Kim Ramil C. Montaniel , et al. · 2016

During the assembly of Figure 10B, incorrect flow cytometry panels were inadvertently included for the Tg sm/p22phox + tempol sample.In addition, a different replicate is now provided for the Tg sm/p22phox sample in Figure 10A.The correct …

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response Open

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Tuantuan Zhao, Masahiro Eriguchi , et al. · 2016

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleave…

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli Open

Hana A. Itani, Liang Xiao, Mohamed A. Saleh, Jing Wu, Mark A. Pilkinton , et al. · 2016

Rationale: Accumulating evidence supports a role of adaptive immunity and particularly T cells in the pathogenesis of hypertension. Formation of memory T cells, which requires the costimulatory molecule CD70 on antigen-presenting cells, is…

Immune activation caused by vascular oxidation promotes fibrosis and hypertension Open

Jing Wu, Mohamed A. Saleh, Annet Kirabo, Hana A. Itani, Kim Ramil C. Montaniel , et al. · 2015

Vascular oxidative injury accompanies many common conditions associated with hypertension. In the present study, we employed mouse models with excessive vascular production of ROS (tg(sm/p22phox) mice, which overexpress the NADPH oxidase s…

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension Open

Kandarp H. Shah, Peng Shi, Jorge F. Giani, Tea Janjulia, Ellen A. Bernstein , et al. · 2015

Rationale : Chronic inflammation is a major contributor to the progressive pathology of hypertension, and T-cell activation is required for the genesis of hypertension. However, the precise role of myeloid cells in this process is unclear.…

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme Open

Jorge F. Giani, Kenneth E. Bernstein, Tea Janjulia, Jiyang Han, Jorge E. Toblli , et al. · 2015

Recent evidence indicates that salt-sensitive hypertension can result from a subclinical injury that impairs the kidneys’ capacity to properly respond to a high-salt diet. However, how this occurs is not well understood. Here, we showed th…

Microglia Participate in Neurogenic Regulation of Hypertension Open

Xiao Z. Shen, You Li, Liang Li, Kandarp H. Shah, Kenneth E. Bernstein , et al. · 2015

Hypertension is associated with neuroinflammation and increased sympathetic tone. Interference with neuroinflammation by an anti-inflammatory reagent or overexpression of interleukin-10 in the brain was found to attenuate hypertension. How…

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension Open

Víctor Garcia, Gregory Joseph, Brian Shkolnik, Yan Ding, Frank Fan Zhang , et al. · 2015

Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin-converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase ex…

The intrarenal generation of angiotensin II is required for experimental hypertension Open

Jorge F. Giani, Kandarp H. Shah, Zakir Khan, Ellen A. Bernstein, Xiao Z. Shen , et al. · 2015

Kenneth E. Bernstein YOU? Author Swipe