Kenneth F. Bradstock
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View article: Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
Sphingosine kinase 2 (SK2) may have utility as a prognostic marker in inflammatory diseases such as cancer in which it has been rationalized as a candidate therapeutic target. Here, we show that SK2 has an oncogenic role in acute lymphobla…
View article: Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
Sphingosine kinase 2 (SK2) may have utility as a prognostic marker in inflammatory diseases such as cancer in which it has been rationalized as a candidate therapeutic target. Here, we show that SK2 has an oncogenic role in acute lymphobla…
View article: Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
PDF file - 1070KB, Supplementary methods, Tables S1-S5 and Figures S1-S14 Table S1. Patient Information Table S2. Primers. Table S3. Regulation of c-Myc Target Genes by SK2 Inhibition Table S4. Gene Enrichment Analysis for All Nine Cell Li…
View article: Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
PDF file - 1070KB, Supplementary methods, Tables S1-S5 and Figures S1-S14 Table S1. Patient Information Table S2. Primers. Table S3. Regulation of c-Myc Target Genes by SK2 Inhibition Table S4. Gene Enrichment Analysis for All Nine Cell Li…
View article: An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL Open
Pediatric regimens have improved outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL). However, results remain inferior to children with ALL. The Australasian Leukaemia and Lymphoma Group (ALLG) ALL06 study (anzc…
View article: RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML
RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML Open
First reported in 1999, germline runt-related transcription factor 1 (RUNX1) mutations are a well-established cause of familial platelet disorder with predisposition to myeloid malignancy (FPD-MM). We present the clinical phenotypes and ge…
View article: <scp>CD</scp>300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation
<span>CD</span>300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation Open
Antibody‐based therapy in acute myeloid leukemia ( AML ) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells ( HSPC s). Achieving greater success with therapeutic antibodies …
View article: Activating killer‐cell immunoglobulin‐like receptor haplotype influences clinical outcome following HLA‐matched sibling haematopoietic stem cell transplantation
Activating killer‐cell immunoglobulin‐like receptor haplotype influences clinical outcome following HLA‐matched sibling haematopoietic stem cell transplantation Open
Natural killer cells are thought to influence the outcome of haematopoietic stem cell transplant (HSCT), impacting on relapse, overall survival, graft vs host disease (GvHD) and the control of infection, in part through the complex interpl…
View article: Bone Marrow Graft-Versus-Host Disease in Reduced Intensity Conditioned Major Histocompatibility Complex Matched Murine Allogeneic Hematopoietic Cell Transplantation
Bone Marrow Graft-Versus-Host Disease in Reduced Intensity Conditioned Major Histocompatibility Complex Matched Murine Allogeneic Hematopoietic Cell Transplantation Open
Background: The majority of clinical allogeneic haemopoietic cell transplants (alloHCT) are now performed using reduced intensity conditioning (RIC) instead of myeloablative conditioning (MAC). However, the biology underlying RIC treatment…
View article: Identification of sphingosine kinase 1 as a therapeutic target in B‐lineage acute lymphoblastic leukaemia
Identification of sphingosine kinase 1 as a therapeutic target in B‐lineage acute lymphoblastic leukaemia Open
Sphingosine 1-phosphate (S1P) is generated from the phosphorylation of sphingosine by sphingosine kinase 1 (SPHK1) or sphingosine kinase 2 (SPHK2) (Pyne et al, 2016). Overexpression of SPHK1 has indisputable tumour-promoting properties (Py…
View article: The immunogenicity of 7‐valent pneumococcal conjugate vaccine (PCV7) in adult bone marrow transplant patients
The immunogenicity of 7‐valent pneumococcal conjugate vaccine (PCV7) in adult bone marrow transplant patients Open
Haematopoietic stem cell transplant (HSCT) and bone marrow transplant (BMT) recipients are at increased risk of developing infections, including invasive pneumococcal disease (IPD) (Kulkarni et al, 2000; Johnston & Conly, 2002). The use of…
View article: CMRF-56<sup>+</sup>blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses
CMRF-56<sup>+</sup>blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses Open
There are numerous transcriptional, proteomic and functional differences between monocyte-derived dendritic cells (Mo-DC) and primary blood dendritic cells (BDC). The CMRF-56 monoclonal antibody (mAb) recognizes a cell surface marker, whic…
View article: A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset
A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset Open
Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in …
View article: Identifying the Need for a Regional Nurse–Led Allogeneic Haematopoietic Stem Cell Transplant (allo-HSCT) Late Effects Follow Up Program
Identifying the Need for a Regional Nurse–Led Allogeneic Haematopoietic Stem Cell Transplant (allo-HSCT) Late Effects Follow Up Program Open
Advances in allo-HSCT technologies have improved survival in patients. Wingard (2011) identified allo-HSCT recipients alive at 2 years post allo-HSCT had an 80-92% survival at 10 years. As a result patients experience chronic and late comp…
View article: The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent
The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent Open
The presence of activated CMRF-44+ (Lau, 2007, Transplantation, 83:839) and CCR5+ CD16+ (Shahin, 2013, Transplantation, 96:753) dendritic cells (DC) predicted for acute graft versus host disease (GVHD) after clinical allogeneic hematopoiet…