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View article: Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease
Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease Open
Pelvic inflammatory disease (PID), which involves infection and inflammation of the female reproductive tract, can lead to sequelae including chronic pelvic pain, ectopic pregnancy and tubal factor infertility. A causative pathogen is not …
View article: AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH and AIH
AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH and AIH Open
Aims Annotation of liver biopsies for disease staging is increasingly aided by digital pathology; however, existing systems do not quantify inflammation and steatosis within an anatomical framework. We hypothesise that an artificial intell…
View article: AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH, and AIH
AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH, and AIH Open
Background & Aims Annotation of liver biopsies, for disease staging is increasingly aided by digital pathology, however existing systems do not quantify inflammation and steatosis within an anatomical framework. We developed an AI system t…
Preserving the Midwifery Model of Care on a High Acuity Labor and Delivery Unit: Midwives’ Perspectives Working in a US Tribal Health System Open
Today nearly 9 out of 10 certified nurse‐midwives/certified midwives (CNMs/CMs) attend births in hospitals. As the demand for hospital midwifery care has increased over the last quarter century, CNM/CMs' scope of practice has expanded to i…
Lipidomic Analysis of Flt3-ITD AML Cells Treated with Intensive Chemotherapy and Independent of Concomitant Sorafenib Display a Profile of Increased Susceptibility to Ferroptosis Open
Introduction The randomised trial of (pre-allogeneic transplant) 2:1 sorafenib to placebo plus intensive chemotherapy in Flt3-ITD AML (Blood, 2023 Dec 7) did not meet the primary end-point of improved event-free survival (EFS) after a medi…
Development of an online teaching platform to improve access to postgraduate pathology training in sub-Saharan Africa Open
Background Resource barriers to the provision of accessible training in cancer diagnosis in lower- and middle-income countries (LMICs) limit the potential of African health systems. Long-term provision via teaching visits from senior patho…
Quantitative digital pathology enables automated and quantitative assessment of inflammatory activity in patients with autoimmune hepatitis Open
Quantitative assessment of liver biopsy using quantitative digital pathology metrics correlates well with traditional pathology scores and key biochemical markers. Whole-slide quantification of disease can support stratification and identi…
View article: Improved pathology reporting in NAFLD/NASH for clinical trials
Improved pathology reporting in NAFLD/NASH for clinical trials Open
Non-alcoholic fatty liver disease (NAFLD), a disorder characterised by pathological accumulation of non-visible free fatty acids and visible triglyceride in hepatocytes, is on the rise globally in both adult and paediatric populations.1 Ev…
Evaluating urban–rural access to pathology and laboratory medicine services in Tanzania Open
Placement of pathology and laboratory medicine (PALM) services requires balancing efficiency (maximizing test volume) with equitable urban–rural access. We compared the association between population density (proxy for efficiency) and trav…
Geographic Variation in Access to Pathology and Laboratory Services in Tanzania: A Cross-Sectional Geospatial Analysis Open
PURPOSE Increasing noncommunicable disease burden in sub-Saharan Africa requires the urgent scale-up of pathology and laboratory medicine (PALM) services. To identify service gaps at the district level, we studied geographic variation in t…
Establishing the College of Pathologists of East, Central and Southern Africa – The Regional East Central and Southern Africa College of Pathology Open
This paper describes the journey that COPECSA has made towards standardising the practice and training of pathology in the East Central and Southern Africa region.
Addressing the shortage of pathologists in Africa: Creation of a MMed Programme in Pathology in Zambia Open
Background: With approximately one pathologist for one million people compared to ratios of approximately 1 to 25 000 in the United States and United Kingdom, there is a severe shortage of pathologists in much of Africa. The situation is p…
Effective coding is key to the development and use of the WHO Essential Diagnostics List Open
The WHO new Essential Diagnostics List (EDL) aims to provide a structure for identifying, promoting, and increasing the supply and availability of the most effective and important in-vitro diagnostics (a full list of the included diagnosti…
Pathology and cancer in Africa Open
In high-income countries, it would be inconceivable to treat a tumour when its pathology is unknown. However, this can be the case among patients in sub-Saharan Africa. The absence of pathologists and the resultant delays in reporting cont…
The Top 25 Laboratory Tests by Volume and Revenue in Five Different Countries Open
Most of the most common tests also appear in the new Essential Diagnostics List. This may inform plans for universal health coverage.
Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores Open
These results suggest that DIA-CPA is the most robust method for assessing liver fibrosis followed by visual-CPA. Categorical scores perform less well than both the quantitative CPA scores assessed here.
Improving Global Access to Diagnostic Testing Open
The deep problems of lack of good-quality pathology in many countries across the globe are being increasingly documented and solutions proposed.1 A key cause has been the “cloak of invisibility” that has surrounded the need for, and the ne…
Multiparametric magnetic resonance imaging for the assessment of non‐alcoholic fatty liver disease severity Open
Background & Aims The diagnosis of non‐alcoholic steatohepatitis and fibrosis staging are central to non‐alcoholic fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment of non‐alcoholic steatohep…
An Essential Pathology Package for Low- and Middle-Income Countries Open
Pathology is an essential component of good universal health care.
Multiorgan Dysfunction Syndrome from Strongyloides stercoralis Hyperinfection in a Patient with Human T-Cell Lymphotropic Virus-1 Coinfection After Initiation of Ivermectin Treatment Open
Strongyloides stercoralis is well known to cause hyperinfection syndrome during the period of immunosuppression; but dissemination, worsening hyperinfection, and development of multiorgan dysfunction syndrome after initiation of ivermectin…