Kenneth G. Sexton
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View article: A case of occult obstructive sleep apnea
A case of occult obstructive sleep apnea Open
View article: Supplementary Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Supplementary Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Open
Supplementary data
View article: Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Open
Purpose:Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-ta…
View article: Supplementary Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Supplementary Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Open
Supplementary data
View article: Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Data from Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Open
Purpose:Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-ta…
View article: Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors Open
Purpose: Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-t…
View article: TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors
TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors Open
T cells have a unique capability to eliminate cancer cells and fight malignancies. Cancer cells have adopted multiple immune evasion mechanisms aimed at inhibiting T cells. Dramatically improved patient outcomes have been achieved with the…
View article: Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas
Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas Open
Atmospheric pollution represents a complex mixture of air chemicals that continually interact and transform, making it difficult to accurately evaluate associated toxicity responses representative of real-world exposure. This study leverag…
View article: Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice
Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice Open
This study was designed to compare the cardiovascular effects of inhaled photochemically altered diesel exhaust (aged DE) to freshly emitted DE (fresh DE) in female C57Bl/6 mice. Mice were exposed to either fresh DE, aged DE, or filtered a…
View article: Construction and Characterization of an Indoor Smog Chamber for Measuring the Optical and Physicochemical Properties of Aging Biomass Burning Aerosols
Construction and Characterization of an Indoor Smog Chamber for Measuring the Optical and Physicochemical Properties of Aging Biomass Burning Aerosols Open
We describe here the construction and characterization of a new combustion-chamber system (the NCAT chamber) for studying the optical and physicochemical properties of biomass burning (BB) aerosols. This system is composed of a ~9 m3 fluor…
View article: Construction and Characterization of an Indoor Smog Chamberfor the Measurement of the Optical and PhysicochemicalProperties of Aging Biomass Burning Aerosols Native to sub-Saharan Africa
Construction and Characterization of an Indoor Smog Chamberfor the Measurement of the Optical and PhysicochemicalProperties of Aging Biomass Burning Aerosols Native to sub-Saharan Africa Open
We describe here the construction and characterization of a new smog chamber facility (NCAT chamber) for studying the chemical and optical properties of biomass burning (BB) aerosols from biomass fuels native to sub-Saharan Africa. This fa…
View article: Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice Open
These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a "compensation" for underlying genetic-driven interindividual differences in the baseline chromatin and transcripti…
View article: Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution
Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution Open
LDH and IL-8 are robust endpoints for assessing toxicity in A549 cells. The EpiAirway™ cells show minimal adverse effects after exposure suggesting that they are more toxicologically resistant compared to A549 cells. Higher concentrations …
View article: Test beam evaluation of newly developed n-in-p planar pixel sensors for use in a high radiation environment
Test beam evaluation of newly developed n-in-p planar pixel sensors for use in a high radiation environment Open
Radiation-tolerant n-in-p planar pixel sensors have been under development in cooperation with Hamamatsu Photonics K.K. (HPK). This is geared towards applications in high-radiation environments, such as for the future Inner Tracker (ITk) p…
View article: In Vitro Exposures in\nDiesel Exhaust Atmospheres:\nResuspension of PM from Filters versus Direct Deposition of PM from\nAir
In Vitro Exposures in\nDiesel Exhaust Atmospheres:\nResuspension of PM from Filters versus Direct Deposition of PM from\nAir Open
One of the most widely used in vitro particulate\nmatter (PM) exposures methods is the collection of PM on filters,\nfollowed by resuspension in a liquid medium, with subsequent addition\nonto a cell culture. To avoid disruption of …
View article: Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution
Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution Open
EpiAirway™ 3-D constructs are human-derived cell cultures of differentiated airway epithelial cells that may represent a more biologically relevant model of the human lung. However, limited information is available of its utility for expos…
View article: In Vitro Exposure to Isoprene-Derived Secondary Organic Aerosol by Direct Deposition and its Effects on COX-2 and IL-8 Gene Expression
In Vitro Exposure to Isoprene-Derived Secondary Organic Aerosol by Direct Deposition and its Effects on COX-2 and IL-8 Gene Expression Open
Atmospheric oxidation of isoprene, the most abundant non-methane hydrocarbon emitted into Earth's atmosphere primarily from terrestrial vegetation, is now recognized as a major contributor to the global secondary organic aerosol (SOA) burd…
View article: Assessment of SAPRC07 with updated isoprene chemistry against outdoor chamber experiments
Assessment of SAPRC07 with updated isoprene chemistry against outdoor chamber experiments Open
Isoprene, the most emitted non-methane hydrocarbon, is known to influence ozone (O3) formation in urban areas rich with biogenic emissions. To keep up with the recent advance on isoprene oxidation chemistry including the identification of …
View article: From the Field to the Laboratory: Air Pollutant-Induced Genomic Effects in Lung Cells
From the Field to the Laboratory: Air Pollutant-Induced Genomic Effects in Lung Cells Open
Current in vitro studies do not typically assess cellular impacts in relation to real-world atmospheric mixtures of gases. In this study, we set out to examine the feasibility of measuring biological responses at the level of gene expressi…