Kenneth Iregbu
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View article: The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050
The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050 Open
Wellcome Trust, and the UK Department of Health and Social Care using aid funding managed by the Fleming Fund.
View article: Beyond the samples: Nigerian research staff perspectives on a multicentre neonatal sepsis study’s impact
Beyond the samples: Nigerian research staff perspectives on a multicentre neonatal sepsis study’s impact Open
Drawing on experiences of Nigerian healthcare staff in a multi-centre international study, we describe insights into capacity strengthening, patients’ engagement, and discuss long-term challenges in sustaining outcomes after project fundin…
View article: Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage Open
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths ann…
View article: Comparative evaluation of DNA extraction protocols for neonatal gut microbiota profiling in a resource-limited setting
Comparative evaluation of DNA extraction protocols for neonatal gut microbiota profiling in a resource-limited setting Open
Accurate and reproducible gut microbiome profiling depends heavily on the DNA extraction method, particularly in low-biomass samples such as neonatal stool. In this study, we evaluated the performance of three commercially available DNA ex…
View article: Global health equity and diagnosis of sepsis in low-income and middle-income countries
Global health equity and diagnosis of sepsis in low-income and middle-income countries Open
View article: Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria
Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria Open
Background Multidrug-resistant Escherichia coli poses a critical public health threat in Nigeria, where limited genomic surveillance hinders the understanding of virulence-resistance interplay. Methods This cross-sectional study employed w…
View article: The impact of the COVID-19 pandemic on antimicrobial usage: an international patient-level cohort study
The impact of the COVID-19 pandemic on antimicrobial usage: an international patient-level cohort study Open
Background This study aimed to evaluate the trends in antimicrobial prescription during the first 1.5 years of COVID-19 pandemic. Methods This was an observational, retrospective cohort study using patient-level data from Bangladesh, Brazi…
View article: Flies as carriers of antimicrobial resistant (AMR) bacteria in Nigerian hospitals: A workflow for surveillance of AMR bacteria carried by arthropod pests in hospital settings
Flies as carriers of antimicrobial resistant (AMR) bacteria in Nigerian hospitals: A workflow for surveillance of AMR bacteria carried by arthropod pests in hospital settings Open
The dissemination of antimicrobial resistant (AMR) bacteria by flies in hospitals is concerning as nosocomial AMR infections pose a significant threat to public health. This threat is compounded in low- and middle-income countries (LMICs) …
View article: Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 Open
Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care using UK aid funding managed by the Fleming Fund.
View article: Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria
Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria Open
Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- and middle-income countries (LMICs). During the BARNARDS study, hospital surfaces from neonata…
View article: Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria
Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria Open
View article: Mapping heterogeneity in family planning indicators in Burkina Faso, Kenya, and Nigeria, 2000–2020
Mapping heterogeneity in family planning indicators in Burkina Faso, Kenya, and Nigeria, 2000–2020 Open
Background Family planning is fundamental to women’s reproductive health and is a basic human right. Global targets such as Sustainable Development Goal 3 (specifically, Target 3.7) have been established to promote universal access to sexu…
View article: Flies as Carriers of Antimicrobial Resistant (Amr) Bacteria in Nigerian Hospitals: A Workflow for Surveillance of Amr Bacteria Carried by Arthropod Pests in Hospital Settings
Flies as Carriers of Antimicrobial Resistant (Amr) Bacteria in Nigerian Hospitals: A Workflow for Surveillance of Amr Bacteria Carried by Arthropod Pests in Hospital Settings Open
View article: The Impact of the COVID-19 Pandemic on Antimicrobial Usage: An International Patient-Level Cohort Study
The Impact of the COVID-19 Pandemic on Antimicrobial Usage: An International Patient-Level Cohort Study Open
View article: The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis
The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis Open
Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care using UK aid funding managed by the Fleming Fund.
View article: The CLIMIDSON Manual for Antimicrobial Stewardship Programmes in Nigerian Health Care Facilities
The CLIMIDSON Manual for Antimicrobial Stewardship Programmes in Nigerian Health Care Facilities Open
Antimicrobial stewardship (AMS) remains a cornerstone of efforts aimed at improving antimicrobial-related patient safety. It slows the development and spread of antimicrobial resistance (AMR), while helping clinicians to improve clinical o…
View article: The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis
The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis Open
View article: Colonisation of extended spectrum β-lactamase- and carbapenemase-producing bacteria on hospital surfaces from low-/middle-income countries
Colonisation of extended spectrum β-lactamase- and carbapenemase-producing bacteria on hospital surfaces from low-/middle-income countries Open
Inanimate surfaces in hospital settings can harbour bacterial pathogens, which can disseminate and cause nosocomial infections, resulting in unacceptable mortality in low- and middle-income countries (LMICs). As part of the BARNARDS study,…
View article: Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study
Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study Open
View article: Circumstances for treatment and control of invasive Enterobacterales infections in eight hospitals across sub-Saharan Africa: a cross-sectional study
Circumstances for treatment and control of invasive Enterobacterales infections in eight hospitals across sub-Saharan Africa: a cross-sectional study Open
Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation in circumstances for management of such resist…
View article: Mortality Associated with 3<sup>rd</sup> Generation Cephalosporin Resistance in <i>Enterobacterales</i> Bloodstream Infections at Eight Sub-Saharan African Hospitals, a Prospective Cohort Study (MBIRA)
Mortality Associated with 3<sup>rd</sup> Generation Cephalosporin Resistance in <i>Enterobacterales</i> Bloodstream Infections at Eight Sub-Saharan African Hospitals, a Prospective Cohort Study (MBIRA) Open
View article: A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria
A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria Open
Background: The family Enterobacteriaceae belongs to the order Enterobacterales, a large diverse group of Gramnegative, facultatively anaerobic bacteria that sometimes cause multidrug-resistant infections which treatment options are often …
View article: Retrospective Characterization of Noma Cases Found Incidentally across Nigeria during Outreach Programs for Cleft Lip from 2011–2020
Retrospective Characterization of Noma Cases Found Incidentally across Nigeria during Outreach Programs for Cleft Lip from 2011–2020 Open
Reports of cases of noma in Nigeria remain scarce despite its known and devastating effects on victims. This report presents a retrospective cross-sectional study based on data regarding on patients with noma encountered incidentally durin…
View article: Treatment and control of invasive Gram-negative bacterial infection in eight hospitals across sub-Saharan Africa: a cross-sectional study
Treatment and control of invasive Gram-negative bacterial infection in eight hospitals across sub-Saharan Africa: a cross-sectional study Open
Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation in circumstances for management of such resist…
View article: Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria
Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria Open
View article: Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria Open
View article: Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries
Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries Open
Early development of the microbiome has been shown to affect general health and physical development of the infant and, although some studies have been undertaken in high-income countries, there are few studies from low- and middle-income …
View article: Antibiotic Susceptibility Profiles and Detection of Genes Mediating Extended-Spectrum β-Lactamase (Esbl) Production in Escherichia Coli Isolates from National Hospital, Abuja
Antibiotic Susceptibility Profiles and Detection of Genes Mediating Extended-Spectrum β-Lactamase (Esbl) Production in Escherichia Coli Isolates from National Hospital, Abuja Open
Background: Extended-spectrum beta-lactamases (ESBL) are the most widespread of the new beta-lactamases and are a significant threat to patient care in the hospital and the community. Aim: The study assessed the prevalence, antibiotic susc…
View article: Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries
Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries Open
Background In low- and middle-income countries (LMIC) Staphylococcus aureus is regarded as one of the leading bacterial causes of neonatal sepsis, however there is limited knowledge on the species diversity and antimicrobial resistance cau…
View article: Treatment and control of invasive Gram-negative bacterial infection in eight hospitals across sub-Saharan Africa: a cross-sectional study
Treatment and control of invasive Gram-negative bacterial infection in eight hospitals across sub-Saharan Africa: a cross-sectional study Open
Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation in circumstances for management of such resist…