Kenneth L. Chiou
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View article: Single-cell, multi-region profiling of the macaque brain across the lifespan
Single-cell, multi-region profiling of the macaque brain across the lifespan Open
Brain aging is a complex process with profound health and societal consequences. However, the molecular and cellular pathways that govern its temporal progression–along with any cell type-, region-, and sex-specific heterogeneity in such p…
View article: Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions
Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions Open
Patterns of brain aging are generally conserved among primates; however, there is marked variation in the observed rate among individuals, species, and brain regions. The hippocampus is a region particularly susceptible to the aging proces…
View article: Age and early life adversity shape heterogeneity of the epigenome across tissues in macaques
Age and early life adversity shape heterogeneity of the epigenome across tissues in macaques Open
Age and early life adversity (ELA) are both key determinants of health, but whether they target similar physiological mechanisms across the body is unknown due to limited multi-tissue datasets from well-characterized cohorts. We generated …
View article: Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics
Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics Open
Western diets and social subordination are associated with increased risk of cardiovascular disease. In this study, we investigated the impact of Western versus Mediterranean diets and social status on atherogenesis and arterial transcript…
View article: SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection
SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection Open
View article: Immune gene regulation is associated with age and environmental adversity in a nonhuman primate
Immune gene regulation is associated with age and environmental adversity in a nonhuman primate Open
Phenotypic aging is ubiquitous across mammalian species, suggesting shared underlying mechanisms of aging. Aging is linked to molecular changes to DNA methylation and gene expression, and environmental factors, such as severe external chal…
View article: Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
Evolutionary and biomedical implications of sex differences in the primate brain transcriptome Open
View article: Marmosets contain multitudes
Marmosets contain multitudes Open
Single-cell RNA sequencing reveals the extent to which marmosets carry genetically distinct cells from their siblings.
View article: Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)
Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis) Open
View article: Mediterranean diet protects against neuroinflammation and degeneration in female nonhuman primates
Mediterranean diet protects against neuroinflammation and degeneration in female nonhuman primates Open
Background Mediterranean diets may reduce Alzheimer’s disease (AD) risk and preserve cognitive function relative to Western diets in part by protecting against neuroinflammation. In middle‐aged humans that subsequently develop AD, increase…
View article: Mediterranean diet protects against neuroinflammation and degeneration in female nonhuman primates
Mediterranean diet protects against neuroinflammation and degeneration in female nonhuman primates Open
Background Mediterranean diets may reduce Alzheimer’s disease (AD) risk and preserve cognitive function relative to Western diets in part by protecting against neuroinflammation. In middle‐aged humans that subsequently develop AD, increase…
View article: Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety
Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety Open
INTRODUCTION Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood. METHODS We assessed the effects of Western vs. Mediterranean-like diets o…
View article: A single-cell multi-omic atlas spanning the adult rhesus macaque brain
A single-cell multi-omic atlas spanning the adult rhesus macaque brain Open
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. …
View article: The biology of aging in a social world: Insights from free-ranging rhesus macaques
The biology of aging in a social world: Insights from free-ranging rhesus macaques Open
View article: Best practices for genotype imputation from low‐coverage sequencing data in natural populations
Best practices for genotype imputation from low‐coverage sequencing data in natural populations Open
Monitoring genetic diversity in wild populations is a central goal of ecological and evolutionary genetics and is critical for conservation biology. However, genetic studies of nonmodel organisms generally lack access to species‐specific g…
View article: Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons
Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons Open
Baboons (genus Papio ) are a morphologically and behaviorally diverse clade of catarrhine monkeys that have experienced hybridization between phenotypically and genetically distinct phylogenetic species. We used high-coverage whole-genome …
View article: Human microglia show unique transcriptional changes in Alzheimer’s disease
Human microglia show unique transcriptional changes in Alzheimer’s disease Open
View article: Vascularization underlies differences in sexually selected skin coloration in a wild primate
Vascularization underlies differences in sexually selected skin coloration in a wild primate Open
Male reproductive competition can select for condition‐dependent, conspicuous traits that signal some aspect of fighting ability and facilitate assessment of potential rivals. However, the underlying mechanisms that link the signal to a ma…
View article: Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons
Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons Open
Baboons (genus Papio ) are a morphologically and behaviorally diverse clade of catarrhine monkeys that have experienced hybridization between phenotypically and genetically distinct phylogenetic species. We used high coverage whole genome …
View article: The biology of aging in a social world: insights from free-ranging rhesus macaques
The biology of aging in a social world: insights from free-ranging rhesus macaques Open
Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for in…
View article: Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment Open
View article: A generalizable epigenetic clock captures aging in two nonhuman primates
A generalizable epigenetic clock captures aging in two nonhuman primates Open
Epigenetic clocks generated from DNA methylation array data provide important insights into biological aging, disease susceptibility, and mortality risk. However, these clocks cannot be applied to high-throughput, sequence-based datasets m…
View article: Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
Evolutionary and biomedical implications of sex differences in the primate brain transcriptome Open
Humans exhibit sex differences in the prevalence of many neurodevelopmental and neurodegenerative conditions. To better understand the translatability of a critical nonhuman primate model, the rhesus macaque, we generated one of the larges…
View article: A single-cell multi-omic atlas spanning the adult rhesus macaque brain
A single-cell multi-omic atlas spanning the adult rhesus macaque brain Open
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. A…
View article: Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer’s Disease and aged human brain
Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer’s Disease and aged human brain Open
Microglia contribute to Alzheimer’s Disease (AD) progression and are candidate therapeutic targets for disease modulation. Single cell transcriptomics demonstrate microglia adopt multiple phenotypes. However, identifying the human AD micro…
View article: Stronger maternal social bonds and higher rank are associated with accelerated infant maturation in Kinda baboons
Stronger maternal social bonds and higher rank are associated with accelerated infant maturation in Kinda baboons Open
View article: Social connections predict brain structure in a multidimensional free-ranging primate society
Social connections predict brain structure in a multidimensional free-ranging primate society Open
Reproduction and survival in most primate species reflects management of both competitive and cooperative relationships. Here, we investigated the links between neuroanatomy and sociality in free-ranging rhesus macaques. In adults, the num…
View article: Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas
Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas Open
View article: Natural disaster and immunological aging in a nonhuman primate
Natural disaster and immunological aging in a nonhuman primate Open
Significance Survivors of extreme adverse events, including natural disasters, often exhibit chronic inflammation and early onset of age-related diseases. Adversity may therefore accelerate aging via the immune system, which is sensitive t…
View article: Experiencing a Natural Disaster Accelerates Aging of the Immune System
Experiencing a Natural Disaster Accelerates Aging of the Immune System Open
Extreme adverse events such as natural disasters can accelerate disease progression and promote chronic inflammation. These phenotypes also increase in prevalence with age, suggesting that experiencing adversity might accelerate aging of t…