Kenneth McIntosh
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View article: Vaccination against Hendra virus of previously unvaccinated mares and their foals demonstrates the effectiveness of the current prime and boost vaccination schedule for foals
Vaccination against Hendra virus of previously unvaccinated mares and their foals demonstrates the effectiveness of the current prime and boost vaccination schedule for foals Open
Hendra virus (HeV) is a high consequence pathogen that causes severe respiratory and/or neurological disease in both horses and humans with high mortality. The equine vaccine, Equivac® HeV, is a recombinant soluble version of the G glycopr…
View article: Catalase in Unexpected Places: Revisiting H2O2 Detoxification Pathways in Stallion Spermatozoa
Catalase in Unexpected Places: Revisiting H2O2 Detoxification Pathways in Stallion Spermatozoa Open
Oxidative stress plays a critical role in regulating sperm function, yet species-specific antioxidant mechanisms remain poorly understood. This study compared hydrogen peroxide (H2O2) tolerance in horse and human sperm and investigated the…
View article: A Comparative Analysis of the Antioxidant Profiles Generated by the RoXstaTM System for Diverse Biological Fluids Highlights the Powerful Protective Role of Human Seminal Plasma
A Comparative Analysis of the Antioxidant Profiles Generated by the RoXstaTM System for Diverse Biological Fluids Highlights the Powerful Protective Role of Human Seminal Plasma Open
(1) Background: The RoXstaTM system has been developed as a rapid, effective means of profiling different types of antioxidant activity. The purpose of this study was to examine its performance utilizing a diverse array of biological fluid…
View article: Comparative Analysis of the Antioxidant Profiles Associated Complex Biofluids, Highlights the Powerful Protective Role of Human Seminal Plasma
Comparative Analysis of the Antioxidant Profiles Associated Complex Biofluids, Highlights the Powerful Protective Role of Human Seminal Plasma Open
(1) Background: The RoXstaTM system has been developed as a potential diagnostic tool to profile the antioxidant activity of complex biological fluids. (2) Methods: This methodology was used to assess the ability of different biofluids (se…
View article: Proving Etiologic Relationships to Disease
Proving Etiologic Relationships to Disease Open
Ten years ago, I wrote an Editorial for the Pediatric Infectious Diseases Journal commenting on the difficulty of proving the pathogenicity of the common cold human coronaviruses (ccHCoVs) when asymptomatic infections were so common.1 The …
View article: Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)
Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338) Open
Background The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites (21 protease inhibi…
View article: Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana
Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana Open
Background: The World Health Organization HIV guidelines recommend either infant zidovudine (ZDV) or nevirapine (NVP) prophylaxis for the prevention of intrapartum motherto-child HIV transmission (MTCT) among formula-fed infants. No study …