Kenneth Ng
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View article: The impact of socioeconomic status with overall survival in hepatocellular carcinoma: a systematic review and meta-analysis
The impact of socioeconomic status with overall survival in hepatocellular carcinoma: a systematic review and meta-analysis Open
View article: An engineered redox‐switchable streptavidin mutein enables the high‐affinity capture and efficient elution of biotinylated ligands
An engineered redox‐switchable streptavidin mutein enables the high‐affinity capture and efficient elution of biotinylated ligands Open
Although the high affinity and specificity of the interaction between streptavidin and biotin are widely utilized to isolate biotinylated ligands, their elution over practical timescales requires the use of strongly denaturing conditions t…
View article: Maternal den preferences, reproductive behavior, and spatial use of a wild Manis javanica during maternal and non-maternal stages in Sabah, Borneo
Maternal den preferences, reproductive behavior, and spatial use of a wild Manis javanica during maternal and non-maternal stages in Sabah, Borneo Open
We present a comprehensive long-term (176 d) report on a wild nursing female (6.4 kg, total length: 99 cm) Sunda pangolin Manis javanica in a highly fragmented area of Borneo. Using VHF tracking and camera trap monitoring, we aimed to addr…
View article: Protocol to implement saturation mutagenesis-reinforced functional assays to resolve small-sized variants in disease-related genes
Protocol to implement saturation mutagenesis-reinforced functional assays to resolve small-sized variants in disease-related genes Open
Determining the functional impacts of disease-causing genetic variants presents consistent challenges in the genetic disease field. Here, we present a protocol for implementing saturation mutagenesis-reinforced functional assays to generat…
View article: <i>Campylobacter jejuni</i> resistance to human milk involves the acyl carrier protein AcpP
<i>Campylobacter jejuni</i> resistance to human milk involves the acyl carrier protein AcpP Open
Campylobacter jejuni is a common foodborne pathogen worldwide that is associated with high rates of morbidity and mortality among infants in low- to middle-income countries (LMICs). Human milk provides infants with an important source of n…
View article: Editorial: Engineering antibodies and bacteriophages to manage and diagnose microbial infections
Editorial: Engineering antibodies and bacteriophages to manage and diagnose microbial infections Open
View article: Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border
Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border Open
Conventional metrics for tracking infectious diseases, including case and outbreak data and syndromic surveillance, can be resource-intensive, misleading, and comparatively slow with prolonged data collection, analysis and authentication. …
View article: Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution
Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution Open
View article: Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy
Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy Open
Several proteins from plant pathogenesis-related family 10 (PR10) are highly abundant in the latex of opium poppy and have recently been shown to play diverse and important roles in the biosynthesis of benzylisoquinoline alkaloids (BIAs). …
View article: Wastewater Surveillance to Confirm Differences in Influenza A Infection between Michigan, USA, and Ontario, Canada, September 2022–March 2023
Wastewater Surveillance to Confirm Differences in Influenza A Infection between Michigan, USA, and Ontario, Canada, September 2022–March 2023 Open
Wastewater surveillance is an effective way to track the prevalence of infectious agents within a community and, potentially, the spread of pathogens between jurisdictions. We conducted a retrospective wastewater surveillance study of the …
View article: Evaluating and optimizing Acid-pH and Direct Lysis RNA extraction for SARS-CoV-2 RNA detection in whole saliva
Evaluating and optimizing Acid-pH and Direct Lysis RNA extraction for SARS-CoV-2 RNA detection in whole saliva Open
View article: Optimized Recombinant Expression and Purification of the SARS‐CoV‐2 Polymerase Complex
Optimized Recombinant Expression and Purification of the SARS‐CoV‐2 Polymerase Complex Open
An optimized protocol has been developed to express and purify the core RNA‐dependent RNA polymerase (RdRP) complex from the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). The expression and purification of active core SARS‐…
View article: <i>Campylobacter jejuni</i> uses energy taxis and a dehydrogenase enzyme for <scp>l</scp> -fucose chemotaxis
<i>Campylobacter jejuni</i> uses energy taxis and a dehydrogenase enzyme for <span>l</span> -fucose chemotaxis Open
Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide, and infection in infants is associated with growth stunting in low- and middle-income countries. Approximately half of all C. jejuni isolates are asaccharolytic, whil…
View article: 949 Flexible control of T cell memory and self-renewal by a reversible epigenetic switch
949 Flexible control of T cell memory and self-renewal by a reversible epigenetic switch Open
Background Self-renewing T cells maintain robust immune responses against pathogens and tumors. In acute infections, T cells maintain self-renewal capabilities after pathogen clearance to generate memory. In chronic infections and tumors, …
View article: Actionable wastewater surveillance: application to a university residence hall during the transition between Delta and Omicron resurgences of COVID-19
Actionable wastewater surveillance: application to a university residence hall during the transition between Delta and Omicron resurgences of COVID-19 Open
Wastewater surveillance has gained traction during the COVID-19 pandemic as an effective and non-biased means to track community infection. While most surveillance relies on samples collected at municipal wastewater treatment plants, surve…
View article: A bioorthogonal antibody-based chemically-induced-dimerization switch for therapeutic application
A bioorthogonal antibody-based chemically-induced-dimerization switch for therapeutic application Open
We present the Indinavir Ligand Induced Transient Engagement switch (IDV LITE Switch), a fully synthetic Chemically Induced Dimerization (CID) system wherein two humanized antibody fragments are heterodimerized by the antiviral drug indina…
View article: Supplementary Table from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Table from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Table S1
View article: Data from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Data from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3–ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm…
View article: Supplementary Methods from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Methods from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Supplementary Methods
View article: Supplementary Methods from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Methods from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Supplementary Methods
View article: Supplementary Table from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Table from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Table S1
View article: Supplementary Figures from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Figures from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Figures S1, S2, S3, S4, and S5
View article: Supplementary Figures from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Supplementary Figures from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
Figures S1, S2, S3, S4, and S5
View article: Data from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers
Data from Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i>-Rearranged Cancers Open
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3–ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm…
View article: Figure S2 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Figure S2 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Oncoprint of all somatic alterations detected on MSK-IMPACT
View article: Figure S2 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Figure S2 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Oncoprint of all somatic alterations detected on MSK-IMPACT
View article: Supplementary Tables from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Supplementary Tables from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Tables S1-S6
View article: Supplementary Tables from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Supplementary Tables from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Tables S1-S6
View article: Data from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Data from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Purpose:Gemcitabine and albumin-bound paclitaxel (ABP) exhibit synergistic antitumor efficacy, with ABP serving to increase the intratumoral gemcitabine concentration. Both drugs are active in squamous cell lung cancers (SQCLC) and are con…
View article: Figure S1 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Figure S1 from A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers Open
Survival plots