Explanipedia

Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort Open

Bryan A. Bassig, Lawrence S. Engel, Hilde Langseth, Tom K. Grimsrud, Kenneth P. Cantor , et al. · 2023

Data from Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure Open

Craig Steinmaus, Catterina Ferreccio, Johanna Acevedo, Yan Yuan, Jane Liaw , et al. · 2023

Background: From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life…

Data from Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure Open

Craig Steinmaus, Catterina Ferreccio, Johanna Acevedo, Yan Yuan, Jane Liaw , et al. · 2023

Background: From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life…

Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure Open

Craig Steinmaus, Catterina Ferreccio, Johanna Acevedo, Yan Yuan, Jane Liaw , et al. · 2023

PDF - 115K, Table S1. Comparison of subjects included in this analysis to subjects excluded because they had high exposures both in early life and adulthood. Table S2. Comparison of residences of the Chile case control study controls at th…

Supplementary Table 1 from Selenium and Bladder Cancer Risk: a Meta-analysis Open

André F.S. Amaral, Kenneth P. Cantor, Debra T. Silverman, Núria Malats · 2023

Supplementary Table 1 from Selenium and Bladder Cancer Risk: a Meta-analysis

Supplementary Table 1 from Selenium and Bladder Cancer Risk: a Meta-analysis Open

André F.S. Amaral, Kenneth P. Cantor, Debra T. Silverman, Núria Malats · 2023

Supplementary Table 1 from Selenium and Bladder Cancer Risk: a Meta-analysis

Data from Selenium and Bladder Cancer Risk: a Meta-analysis Open

André F.S. Amaral, Kenneth P. Cantor, Debra T. Silverman, Núria Malats · 2023

Background: Selenium is considered to be an antioxidant, and its high levels have been inversely associated with cancer risk of several sites. This meta-analysis examined the relationship between levels of selenium measured in serum…

Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure Open

Craig Steinmaus, Catterina Ferreccio, Johanna Acevedo, Yan Yuan, Jane Liaw , et al. · 2023

PDF - 115K, Table S1. Comparison of subjects included in this analysis to subjects excluded because they had high exposures both in early life and adulthood. Table S2. Comparison of residences of the Chile case control study controls at th…

Data from Selenium and Bladder Cancer Risk: a Meta-analysis Open

André F.S. Amaral, Kenneth P. Cantor, Debra T. Silverman, Núria Malats · 2023

Background: Selenium is considered to be an antioxidant, and its high levels have been inversely associated with cancer risk of several sites. This meta-analysis examined the relationship between levels of selenium measured in serum…

Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case–Control Studies Open

Laura E. Beane Freeman, Manolis Kogevinas, Kenneth P. Cantor, Cristina M. Villanueva, Ludmila Prokunina‐Olsson , et al. · 2022

We found novel suggestive evidence for a multiplicative interaction between a putative bladder carcinogen, TTHMs, and genotypes of rs907611. Given the ubiquitous exposure to THMs, further work is needed to replicate and extend this finding…

Drinking water disinfection byproducts and ingested nitrate with the risk of endometrial cancer in postmenopausal women Open

Danielle N. Medgyesi, Britton Trabert, Joshua N. Sampson, Peter J. Weyer, Kenneth P. Cantor , et al. · 2021

BACKGROUND AND AIM: Disinfection by-products (DBPs) and {N}-nitroso compounds, formed endogenously after nitrate/nitrite ingestion, are suspected endometrial carcinogens but epidemiologic studies are limited. We investigated their relation…

Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case–control study Open

Cindy M. Chang, Jane C. Schroeder, Wen‐Yi Huang, Cherie H. Dunphy, Ralph S. Baric , et al. · 2020

We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified i…

IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans Open

Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen , et al. · 2020

Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these e…

A case–control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression Open

Cindy M. Chang, Jane C. Schroeder, Andrew F. Olshan, Cherie H. Dunphy, Wen‐Yi Huang , et al. · 2020

We re-evaluated reported associations between tobacco use and other factors and non-Hodgkin lymphoma (NHL) t(14;18)-subtypes based on fluorescence in situ hybridization (FISH) assays believed to be more sensitive than polymerase chain reac…

Lifetime exposure to disinfection by-products and risk of cancer at six anatomic sites in Iowa, USA Open

Rena R. Jones, Mariana Hildesheim, Laura E. Beane Freeman, Charles F. Lynch, Peter J. Weyer , et al. · 2020

Background: Disinfection by-products (DBPs) are suspected risk factors for multiple cancers. In our population-based case-control study in Iowa, we previously found moderate risks of bladder, brain, and rectal (but not colon, kidney, or pa…

Insecticide use and risk of non‐Hodgkin lymphoma subtypes: A subset meta‐analysis of the North American Pooled Project Open

Linda Kachuri, Laura E. Beane Freeman, John J. Spinelli, Aaron Blair, Manisha Pahwa , et al. · 2020

Insecticide use has been linked to increased risk of non‐Hodgkin lymphoma (NHL), however, findings of epidemiologic studies have been inconsistent, particularly for NHL subtypes. We analyzed 1690 NHL cases and 5131 controls in the North Am…

Prediagnostic serum concentrations of organochlorine pesticides and non-Hodgkin lymphoma: A nested case–control study in the Norwegian Janus Serum Bank Cohort Open

Dazhe Chen, Tom K. Grimsrud, Hilde Langseth, Dana Boyd Barr, Bryan A. Bassig , et al. · 2020

Pesticide use and risk of Hodgkin lymphoma: results from the North American Pooled Project (NAPP) Open

Lidija Latifovic, Laura E. Beane Freeman, John J. Spinelli, Manisha Pahwa, Linda Kachuri , et al. · 2020

Purpose The purpose of this study was to investigate associations between pesticide exposures and risk of Hodgkin lymphoma (HL) using data from the North American Pooled Project (NAPP). Methods Three population-based studies conducted in K…

Ingested Nitrate and Nitrite and Bladder Cancer in Northern New England Open

Kathryn Hughes Barry, Rena R. Jones, Kenneth P. Cantor, Laura E. Beane Freeman, David C. Wheeler , et al. · 2019

Background: N -nitroso compounds are hypothesized human bladder carcinogens. We investigated ingestion of N -nitroso compound precursors nitrate and nitrite from drinking water and diet and bladder cancer in the New England Bladder Cancer …

Ingested nitrate and nitrite and bladder cancer in Northern New England Open

Mary H. Ward, Kathryn Hughes Barry, Ryan Jones, Kenneth P. Cantor, Beane Freeman L , et al. · 2019

OPS 36: Health effects of dietary exposures, Room 210, Floor 2, August 27, 2019, 4:30 PM - 5:30 PM Background/Aim: N-nitroso compounds (NOCs) are hypothesized human bladder carcinogens. Nitrate and nitrite are NOC precursors; sources inclu…

Validity of retrospective occupational exposure estimates of lead and manganese in a case–control study Open

Jean‐François Sauvé, Joemy M. Ramsay, Sarah J. Locke, Pamela J. Dopart, Pabitra R Josse , et al. · 2019

Objectives The validity of surrogate measures of retrospective occupational exposure in population-based epidemiological studies has rarely been evaluated. Using toenail samples as bioindicators of exposure, we assessed whether work tasks …

Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project Open

Manisha Pahwa, Laura E. Beane Freeman, John J. Spinelli, Aaron Blair, Esther M. John , et al. · 2019

Objectives Some epidemiological studies have suggested positive associations between glyphosate use and non-Hodgkin lymphoma (NHL), but evidence is inconsistent and few studies could evaluate histological sub-types. Here, associations betw…

Epidemiologic Research Priorities on the Health Risk of Drinking Water Contaminants Open

Kenneth P. Cantor · 2019

This chapter reviews the evidence linking drinking water contaminants with human disease, and suggests areas for further research. Traces of natural and man-made radioactivity from radionuclides are found in drinking water supplies through…

Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project Open

Stella Koutros, Shelley A. Harris, John J. Spinelli, Aaron Blair, John McLaughlin , et al. · 2019

Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort Open

Rena R. Jones, Curt T. DellaValle, Peter J. Weyer, Kim Robien, Kenneth P. Cantor , et al. · 2019

Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort Open

Bryan A. Bassig, Lawrence S. Engel, Hilde Langseth, Tom K. Grimsrud, Kenneth P. Cantor , et al. · 2019

Ingested nitrate and nitrite, disinfection by‐products, and pancreatic cancer risk in postmenopausal women Open

Arbor Quist, Maki Inoue‐Choi, Peter J. Weyer, Kristin E. Anderson, Kenneth P. Cantor , et al. · 2017

Nitrate and nitrite are precursors of N ‐nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by‐products (DBP) exposures have also been linked with digestive system cancers, but few stu…

Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case–Control Study (New England, USA) Open

Laura E. Beane Freeman, Kenneth P. Cantor, Dalsu Baris, John R. Nuckols, Alison Johnson , et al. · 2017

We observed a modest association between ingestion of water with higher THMs (>95th percentile vs.<25th percentile) and bladder cancer. Brominated THMs have been a particular concern based on toxicologic evidence, and our suggestive findin…

Ingested Nitrate, Disinfection By-products, and Kidney Cancer Risk in Older Women Open

Rena R. Jones, Peter J. Weyer, Curt T. DellaValle, Kim Robien, Kenneth P. Cantor , et al. · 2017

Relatively high nitrate levels in public water supplies were associated with increased risk of renal cancer. Our results also suggest that nitrite from processed meat is a renal cancer risk factor.

Atrazine in public water supplies and risk of ovarian cancer among postmenopausal women in the Iowa Women's Health Study Open

Maki Inoue‐Choi, Peter J. Weyer, Rena R. Jones, Benjamin J. Booth, Kenneth P. Cantor , et al. · 2016

In our study with low atrazine detection rates, we found no association between atrazine in PWS and postmenopausal ovarian cancer risk.

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