Kenneth P. Nephew
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Author Swipe
View article: Forward genetics identifies HN1L/JPT2 as a novel carboplatin resistance gene in ovarian cancer
Forward genetics identifies HN1L/JPT2 as a novel carboplatin resistance gene in ovarian cancer Open
View article: Supplementary Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Lamin B1 expression and nuclei morphology after tripartite treatment.
View article: Supplementary Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 modulation and responses to forskilin and olaparib.
View article: Supplementary Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 dependent actin reorganization.
View article: Supplementary Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Nuclei morphology following claudin-4 inhibition.
View article: Supplementary Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Confirmation of claudin-4 modulation via genetic and pharmacologic approaches.
View article: Supplementary Figure 8 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 8 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Reactive oxygen species positive control in cell lines.
View article: Supplementary Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Gating strategy for hypertetraploid aneuploidy in epithelial ovarian cancer cells.
View article: Supplementary Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 dependent cell cycle and Lamin expression.
View article: Data from ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer
Data from ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer Open
DNA methyltransferase (DNMT) and PARP inhibitors induce a stimulator of IFN gene–dependent pathogen mimicry response (PMR) in ovarian and other cancers. In this study, we showed that combining DNMT and PARP inhibitors upregulates expressio…
View article: Supplementary Data from ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer
Supplementary Data from ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer Open
Supplementary Figures
View article: Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity
Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity Open
View article: SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma
SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma Open
Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39…
View article: MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer
MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer Open
Ovarian cancer is a deadly gynecologic disease with frequent recurrence. Current treatments for patients include platinum-based therapy regimens with PARP inhibitors specific for homologous recombination–deficient high-grade serous ovarian…
View article: Supplementary Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 dependent cell cycle and Lamin expression.
View article: Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Cellular stress response evaluation in ovarian tumor cells treated with olaparib, FSK, and CMP. Ovarian tumor cells were treated with a tripartite combination of olaparib (600 nmol/L), FSK (5 µmol/L), and CMP (400 µmol/L) for 4 hours to an…
View article: Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 2 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4’s association with various forms of genome instability. Ovarian tumor cells were cultured for 24, 48, and 96 hours. Afterward, cells were PI-stained to quantify aneuploidy, a type of genomic instability in vitro. Likewise,…
View article: Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Cell-cycle progression during claudin-4 modulation. Ovarian tumor cells were cultured and stained for PI at 24, 48 (OVCAR8 and OVCA429 cells), and 96 hours (OVCAR3 cells). Subsequently, cell-cycle progression was evaluated via flow cytomet…
View article: Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Effect of combining olaparib, FSK, and CMP on LAT1 expression. Ovarian tumor cells were treated with a tripartite combination of olaparib (600 nmol/L), FSK (5 µmol/L), and CMP (400 µmol/L) for different time points. Subsequently, cell lysa…
View article: Data from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Data from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Alterations in the interplay between the nucleus and the cell cycle during cancer development lead to a state of genomic instability, often accompanied by observable morphologic aberrations. Tumor cells can regulate these aberrations to ev…
View article: Supplementary Figure 8 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 8 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Reactive oxygen species positive control in cell lines.
View article: Supplementary Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Gating strategy for hypertetraploid aneuploidy in epithelial ovarian cancer cells.
View article: Supplementary Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 7 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Lamin B1 expression and nuclei morphology after tripartite treatment.
View article: Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4’s effect on the actin cytoskeleton. Ovarian tumor cells were treated with CMP (400 µmol/L) for 48 hours and stained to mark the actin cytoskeleton using phalloidin. In addition, cells were engineered to express LifeAct to mark th…
View article: Supplementary Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 1 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Confirmation of claudin-4 modulation via genetic and pharmacologic approaches.
View article: Supplementary Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 modulation and responses to forskilin and olaparib.
View article: Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 6 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Impact of targeting claudin-4’s functional effects via CMP and FSK on ovarian cancer cell survival. Olaparib treatment was used as a reference (Supplementary Fig. S6D–S6F) to evaluate the effects of CMP and FSK on cell survival using the 7…
View article: Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Figure 3 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Remodeling of nuclear morphology and the nuclear lamina during claudin-4 disruption. Ovarian tumor cells were treated with CMP (400 µmol/L) for 48 hours, and then cells were stained to mark the nuclear lamina (using antibodies against lami…
View article: Supplementary Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 4 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Nuclei morphology following claudin-4 inhibition.
View article: Supplementary Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Supplementary Figure 5 from Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival Open
Claudin-4 dependent actin reorganization.