Kenneth R. Scott
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View article: A Comparative Study Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography to Investigate the In Vitro and In Vivo Metabolism of Five Selenium-Containing Cathinone Derivatives
A Comparative Study Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography to Investigate the In Vitro and In Vivo Metabolism of Five Selenium-Containing Cathinone Derivatives Open
Background/Objectives: The emergence of cathinone-based psychostimulants necessitates ongoing research and analysis of the characteristics and properties of novel derivatives. The metabolic fate of five novel cathinone-derived substances (…
View article: Bioisosteric analogs of <scp>MDMA</scp> : Improving the pharmacological profile?
Bioisosteric analogs of <span>MDMA</span> : Improving the pharmacological profile? Open
3,4‐Methylenedioxymethamphetamine (MDMA, ‘ ecstasy’ ) is re‐emerging in clinical settings as a candidate for the treatment of specific neuropsychiatric disorders (e.g. post‐traumatic stress disorder) in combination with psychotherapy. MDMA…
View article: Bioisosteric analogs of MDMA with improved pharmacological profile
Bioisosteric analogs of MDMA with improved pharmacological profile Open
3,4-Methylenedioxymethamphetamine (MDMA, ‘ ecstasy’ ) is re-emerging in clinical settings as a candidate for the treatment of specific psychiatric disorders (e.g. post-traumatic stress disorder) in combination with psychotherapy. MDMA is a…
View article: The Essentiality of the Vinyl Proton in Anticonvulsant Enaminones
The Essentiality of the Vinyl Proton in Anticonvulsant Enaminones Open
Enaminones are chemical compounds consisting of an amino group linked through a C=C bond to a keto group. Enaminones analogs and have been extensively studied in anticonvulsant therapy. They appear to act through two mechanisms, (a) inhibi…