Kenneth Rockwood
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View article: Diagnostic utility of speech-based biomarkers in mild cognitive impairment: a systematic review and meta-analysis
Diagnostic utility of speech-based biomarkers in mild cognitive impairment: a systematic review and meta-analysis Open
Background Among various tools developed for mild cognitive impairment (MCI) detection, analysing speech features is a non-invasive and cost-effective approach that shows promise for early detection. This review aimed to systematically syn…
View article: Epigenetic signature of heterogeneity in aging: Findings from the Canadian Longitudinal Study on Aging
Epigenetic signature of heterogeneity in aging: Findings from the Canadian Longitudinal Study on Aging Open
Human aging does not follow a single trajectory. Epigenetic changes offer insight into the heterogeneity in aging by reflecting the combined influence of genetic, environmental, and lifestyle factors on the timing and progression of age-re…
View article: Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms
Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms Open
Engaging in MVPA and limiting stationary time may be more beneficial on knee osteoarthritis pain and stiffness among frailer older adults.
View article: Can laboratory test-based frailty indices contribute to frailty screening in emergency departments?
Can laboratory test-based frailty indices contribute to frailty screening in emergency departments? Open
Background Laboratory-based frailty indices (FI-Labs) offer potential adjuncts and alternatives to clinical assessments. Still, their optimal configuration and construct validity compared with nurse-assessed Clinical Frailty Scale (CFS) sc…
View article: Validation of the hospital frailty risk score in China
Validation of the hospital frailty risk score in China Open
View article: Validation of the Hospital Frailty Risk Score in China
Validation of the Hospital Frailty Risk Score in China Open
Purpose To validate the Hospital Frailty Risk Score (HFRS) in Chinese hospital settings, describing how patients are allocated to frailty risk groups and how frailty risk is associated with length of stay (LoS) and hospital costs. Design: …
View article: Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events
Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events Open
Background The representation of frailty in type 2 diabetes trials is unclear. This study used individual participant data from trials of newer glucose-lowering therapies to quantify frailty and assess the association between frailty and e…
View article: What can we learn from 68 000 clinical frailty scale scores? Evaluating the utility of frailty assessment in emergency departments
What can we learn from 68 000 clinical frailty scale scores? Evaluating the utility of frailty assessment in emergency departments Open
Background Emergency departments (EDs) in England are under significant strain, with increasing attendances and extended wait times, affecting frail older adults. The clinical frailty scale (CFS) has been implemented as a tool to assess fr…
View article: The early warning paradox
The early warning paradox Open
Machine learning models in healthcare aim to predict critical outcomes but often overlook existing Early Warning Systems’ impact. Using data from King’s College Hospital, we demonstrate how current evaluation methods can lead to paradoxica…
View article: Cost-utility of a new psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: an economic evaluation embedded within a randomised controlled trial
Cost-utility of a new psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: an economic evaluation embedded within a randomised controlled trial Open
Alzheimer's Society.
View article: A214 CONSTRUCTION AND VALIDATION OF A FRAILTY INDEX FOR THE INFLAMMATORY BOWEL DISEASE POPULATION
A214 CONSTRUCTION AND VALIDATION OF A FRAILTY INDEX FOR THE INFLAMMATORY BOWEL DISEASE POPULATION Open
Background Frailty can be defined as a state of vulnerability to adverse health events, resulting from a reduction in physiological processes that are protective for health. Measuring frailty in populations with chronic immune-mediated dis…
View article: Inferring and predicting Fried physical frailty phenotype deficits
Inferring and predicting Fried physical frailty phenotype deficits Open
We predict the Fried physical frailty phenotype health deficits (FPFP5: slow gait, weakness, weight loss, low activity, and exhaustion) using two measures of frailty: frailty index (FI) or frailty phenotype (FP). The FP theorizes that the …
View article: Exploring frailty in Brazil: an analysis of the ELSI-Brazil survey
Exploring frailty in Brazil: an analysis of the ELSI-Brazil survey Open
The Brazilian aging population will challenge publicly funded health services, on which most Brazilians rely. The country must prepare for aging-associated health challenges such as frailty. We used data from the Brazilian Longitudinal Stu…
View article: Engaging older adults in the process of aging research: a multimethod study evaluating the experience and efficacy of a citizen advisory group for a dementia risk reduction program
Engaging older adults in the process of aging research: a multimethod study evaluating the experience and efficacy of a citizen advisory group for a dementia risk reduction program Open
Background Collaborative research with end-users is an effective way to generate meaningful research applications and support greater impact on practice and knowledge exchange. To address these needs, a Citizen Advisory Group (CAG) of nine…
View article: A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples
A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples Open
Background The construct of social vulnerability attempts to understand social circumstances not merely as a descriptor, but as a predictor of adverse health events. It can be measured by aggregating social deficits in a social vulnerabili…
View article: Dynamical modelling of the frailty index indicates that health reaches a tipping point near age 75
Dynamical modelling of the frailty index indicates that health reaches a tipping point near age 75 Open
The frailty index (FI) serves as a useful quantitative summary of age-related health. We quantitatively modelled FI trajectories with age. We fit directly to longitudinal transitions in health attributes from normal to deficit and vice-ver…
View article: MARKERS OF INFLAMMATION ARE MODIFIED BY SEX, FRAILTY AND EXERCISE IN A HEAD-DOWN TILT BEDREST STUDY
MARKERS OF INFLAMMATION ARE MODIFIED BY SEX, FRAILTY AND EXERCISE IN A HEAD-DOWN TILT BEDREST STUDY Open
Prolonged bedrest can induce physiological stress thereby exacerbating frailty and inflammation. We explored whether Head-Down Tilt (HDT) bedrest with or without exercise would alter inflammatory markers implicated in frailty. Twenty 55-65…
View article: Interventions for people living with dementia: updates from 2024 Lancet Commission
Interventions for people living with dementia: updates from 2024 Lancet Commission Open
Background The progressive nature of dementia and the complex needs means that people living with dementia require tailored approaches to address their changing care needs over time. These include physical multimorbidity, psychological, be…
View article: Triangulation to make decisions about what are modifiable risk factors and the new risk factors
Triangulation to make decisions about what are modifiable risk factors and the new risk factors Open
Background The 2020 Lancet Commission on dementia prevention, intervention and care estimated that up to 40% of dementia cases could be prevented by tackling 12 potentially modifiable risk factors, namely less education, hearing loss, hype…
View article: Diversity, Equity and Inclusivity‐ Low and Middle Income countries and the Lancet commission
Diversity, Equity and Inclusivity‐ Low and Middle Income countries and the Lancet commission Open
Background Data from high‐income countries (HICs) suggest a decline in age‐specific incidence rates of dementia. However, this has happened primarily in HICs, with low‐ and middle‐ income countries (LMICs) facing two main challenges: a hig…
View article: Potentially modifiable risk factors for dementia putting the evidence together: Total population attributable fraction
Potentially modifiable risk factors for dementia putting the evidence together: Total population attributable fraction Open
Background Our authors from around the world met to summarise the available knowledge, decide which potentially modifiable risk factors for dementia have compelling evidence and create the most comprehensive analysis to date for potentiall…
View article: Short-term Frailty Index Fluctuations in Older Adults: Noise or Signal?
Short-term Frailty Index Fluctuations in Older Adults: Noise or Signal? Open
Background Reversible short-term fluctuations in the frailty index (FI) are often thought of as representing only noise or error. Here, we assess (i) the size and source of short-term FI fluctuations, (ii) variation across sociodemographic…
View article: Short-term frailty index fluctuations in older adults: Noise or signal?
Short-term frailty index fluctuations in older adults: Noise or signal? Open
Background Reversible short-term fluctuations in the frailty index (FI) are often thought of as representing only noise or error. Here, we assess (1) size and source of short-term FI fluctuations, (2) variation across socio-demographics, (…
View article: Delirium and frailty in older adults: Clinical overlap and biological underpinnings
Delirium and frailty in older adults: Clinical overlap and biological underpinnings Open
Frailty and delirium are two common geriatric syndromes sharing several clinical characteristics, risk factors, and negative outcomes. Understanding their interdependency is crucial to identify shared mechanisms and implement initiatives t…
View article: Cost-utility of a new psychosocial goal-setting and manualised support intervention for Independence in Dementia (NIDUS-Family) versus goal-setting and routine care: economic evaluation embedded within a randomised controlled trial
Cost-utility of a new psychosocial goal-setting and manualised support intervention for Independence in Dementia (NIDUS-Family) versus goal-setting and routine care: economic evaluation embedded within a randomised controlled trial Open
Summary Background NIDUS-Family is a 6-8 session, psychosocial and behavioural intervention, delivered by non-clinical facilitators, tailored to goals set by dementia-unpaid/family carer dyads. It is effective in terms of attainment of per…
View article: Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission Open
View article: Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling Open
Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread health improvements across the aging population. Frailty i…
View article: Personalized goals of people living with dementia and family carers: A content analysis of goals set within an individually tailored psychosocial intervention trial
Personalized goals of people living with dementia and family carers: A content analysis of goals set within an individually tailored psychosocial intervention trial Open
Introduction Person‐centered goals capture individual priorities in personal contexts. Goal Attainment Scaling (GAS) has been used in drug trials involving people living with dementia (PLWD) but GAS has been characterized as difficult to i…
View article: Development and validation of a frailty index for use in the osteoarthritis initiative
Development and validation of a frailty index for use in the osteoarthritis initiative Open
Background The Osteoarthritis Initiative (OAI) evaluates the development and progression of osteoarthritis. Frailty captures the heterogeneity in aging. Use of this resource-intensive dataset to answer aging-related research questions coul…
View article: Systems-level health of patients living with end-stage kidney disease using standard lab values
Systems-level health of patients living with end-stage kidney disease using standard lab values Open
We present a systems-level analysis of end-stage kidney disease (ESKD) with a dynamical network analysis of 14 commonly measured blood-based biomarkers in patients undergoing regular haemodialysis. Utilizing a validated pipeline for declin…