Kenneth S. Plante
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View article: Key residues in SARS-CoV-2 NSP3 hyper variable region are necessary to modulate early stress granule activity
Key residues in SARS-CoV-2 NSP3 hyper variable region are necessary to modulate early stress granule activity Open
Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation duri…
View article: Genomic characterization of arboviruses discovered between the 1950s and 1980s
Genomic characterization of arboviruses discovered between the 1950s and 1980s Open
Arthropod-borne viruses (arboviruses) pose a major threat to global public health, impacting both human and animal health. Genomic characterization is important for arboviruses because it allows for an understanding of their evolution and …
View article: γδ T Cells Mediate Protective Immunity Following Vaccination with an Insect-Based Chikungunya Fever Vaccine in Mice
γδ T Cells Mediate Protective Immunity Following Vaccination with an Insect-Based Chikungunya Fever Vaccine in Mice Open
Eilat (EILV)/chikungunya virus (CHIKV) is a chimeric virus that contains the nonstructural proteins and cis-acting sequences of EILV and the structural proteins of CHIKV. EILV/CHIKV vaccination is known to protect with a single dose agains…
View article: The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2
The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2 Open
The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecoviruses: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop characterized by an upstream QTQTN amino aci…
View article: mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract
mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract Open
Monoclonal antibodies (mAbs) have been developed as effective biological countermeasures against a range of human diseases. The high cost of antibody production and manufacturing limits its clinical application and widespread use. The mRNA…
View article: Molecular basis for shifted receptor recognition by an encephalitic arbovirus
Molecular basis for shifted receptor recognition by an encephalitic arbovirus Open
Western equine encephalitis virus (WEEV) is an arbovirus that historically caused large outbreaks of encephalitis throughout the Americas. WEEV binds protocadherin 10 (PCDH10) as a receptor, and highly virulent ancestral WEEV strains also …
View article: A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID‐19‐Flu Mucosal Vaccines
A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID‐19‐Flu Mucosal Vaccines Open
View article: The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2
The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2 Open
The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecoviruses: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop characterized by an upstream QTQTN amino aci…
View article: Optimization of a panel of behavioral tests for use in containment using a golden Syrian hamster model
Optimization of a panel of behavioral tests for use in containment using a golden Syrian hamster model Open
View article: A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID‐19‐Flu Mucosal Vaccines
A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID‐19‐Flu Mucosal Vaccines Open
A multivalent, rapidly deployable, mucosal vaccine platform is desperately needed to prevent acquisition and transmission of respiratory infections during epidemics and pandemics. No such approved platform currently exists and virtually al…
View article: Molecular basis for shifted receptor recognition by an encephalitic arbovirus
Molecular basis for shifted receptor recognition by an encephalitic arbovirus Open
After decades of inactivity throughout the Americas, western equine encephalitis virus (WEEV) recently re-emerged in South America, causing a large-scale outbreak in humans and horses. WEEV binds protocadherin 10 (PCDH10) as a receptor; ho…
View article: A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques
A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques Open
View article: Cache Valley virus isolation from a horse in Veracruz State, Mexico
Cache Valley virus isolation from a horse in Veracruz State, Mexico Open
Cache Valley virus (CVV) was isolated from a clinically presenting horse in the Mexican Gulf region. CVV is linked to neuroinvasive disease in humans and fetal demise and defects in sheep. This is the first association between CVV and dise…
View article: Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus
Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus Open
View article: Outbreak of Chikungunya Fever in the Central Valley of Chiapas, Mexico
Outbreak of Chikungunya Fever in the Central Valley of Chiapas, Mexico Open
Chikungunya virus (CHIKV) was isolated from humans in an outbreak of a febrile illness during July and August 2015 in the central valleys of Chiapas, Mexico. Sera obtained from 80 patients were tested for CHIKV RNA by reverse transcriptase…
View article: Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants
Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants Open
While first-generation, spike (S)-based COVID-19 vaccines were effective against early SARS-CoV-2 strains, the rapid evolution of novel Omicron subvariants have substantially reduced vaccine efficacy. As such, broadly protective vaccines a…
View article: Shifts in receptors during submergence of an encephalitic arbovirus
Shifts in receptors during submergence of an encephalitic arbovirus Open
View article: Chikungunya Virus: Current Perspectives on a Reemerging Virus.
Chikungunya Virus: Current Perspectives on a Reemerging Virus. Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus in the family Togaviridae that causes outbreaks of debilitating acute and chronic arthralgia in humans. Although historically associated with localized outbreaks in Africa and Asia, …
View article: Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus.
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus. Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with debilitating arthralgia in humans. RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however, the specific role of…
View article: Mechanisms of Flavivirus Cross-Protection against Yellow Fever in a Mouse Model
Mechanisms of Flavivirus Cross-Protection against Yellow Fever in a Mouse Model Open
The complete lack of yellow fever virus (YFV) in Asia, and the lack of urban YFV transmission in South America, despite the abundance of the peridomestic mosquito vector Aedes (Stegomyia.) aegypti is an enigma. An immunologically naïve pop…
View article: A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques
A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques Open
Chikungunya virus (CHIKV), which induces chikungunya fever and chronic arthralgia, is an emerging public health concern. Safe and efficient vaccination strategies are needed to prevent or mitigate virus-associated acute and chronic morbidi…
View article: Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants
Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants Open
A broadly protective vaccine for COVID-19 is needed to end the pandemic and to prevent its future recurrence. While the first-generation, spike-based vaccines are effective against early SARS-CoV-2 strains, the convergent evolution of the …
View article: Pathophysiology of chikungunya virus infection associated with fatal outcomes
Pathophysiology of chikungunya virus infection associated with fatal outcomes Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, vir…
View article: Yellow Fever Emergence: Role of Heterologous Flavivirus Immunity in Preventing Urban Transmission
Yellow Fever Emergence: Role of Heterologous Flavivirus Immunity in Preventing Urban Transmission Open
During major, recent yellow fever (YF) epidemics in Brazil, human cases were attributed only to spillover infections from sylvatic transmission with no evidence of human amplification. Furthermore, the historic absence of YF in Asia, despi…
View article: Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity Open
View article: Potential of Ilhéus virus to emerge
Potential of Ilhéus virus to emerge Open
Ilhéus virus (ILHV)(Flaviviridae:Orthoflavivirus) is an arthropod-borne virus (arbovirus) endemic to Central and South America and the Caribbean. First isolated in 1944, most of our knowledge derives from surveillance and seropreval…
View article: MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques
MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques Open
View article: The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions Open
View article: Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community
Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community Open
Background The first chikungunya virus (CHIKV) outbreaks during the modern scientific era were identified in the Americas in 2013, reaching high attack rates in Caribbean countries. However, few cohort studies have been performed to charac…
View article: Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants Open
The emergence of highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that are resistant to the current COVID-19 vaccines highlights the need for continued development of broadly prot…