Kenneth S. Ramos
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View article: Advances in Artificial Intelligence for Glioblastoma Radiotherapy Planning and Treatment
Advances in Artificial Intelligence for Glioblastoma Radiotherapy Planning and Treatment Open
Glioblastoma is an aggressive central nervous system tumor characterized by diffuse infiltration. Despite substantial advances in oncology, survival outcomes have shown little improvement over the past three decades. Radiotherapy remains a…
View article: Idealized Framework for Assisting Pharmacovigilance Reporting in an Ambulatory Primary Care and Chronic Disease Management Clinic
Idealized Framework for Assisting Pharmacovigilance Reporting in an Ambulatory Primary Care and Chronic Disease Management Clinic Open
Pharmacovigilance approaches have conventionally focused on the use of epidemiological data to detect emergent adverse drug reactions (ADRs). Recent advances in the use and availability of real-world data have expanded opportunities to det…
View article: Exosomal Long Interspersed Nuclear Element‐1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non‐Small Cell Lung Cancer
Exosomal Long Interspersed Nuclear Element‐1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non‐Small Cell Lung Cancer Open
Lung cancer is the leading cause of cancer‐related mortality worldwide, with lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) representing the most common non‐small cell lung cancer (NSCLC) subtypes. The invasive procedur…
View article: Advances in Artificial Intelligence for Glioblastoma Radiotherapy Planning and Treatment
Advances in Artificial Intelligence for Glioblastoma Radiotherapy Planning and Treatment Open
Glioblastoma is an aggressive central nervous system tumor characterized by diffuse infiltration. Despite substantial advances in oncology, survival outcomes have shown little improvement over the past three decades. Radiotherapy remains a…
View article: Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities
Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities Open
Children are more vulnerable to the adverse effects of pesticides due to physiological factors and behavioral habits. This study aimed to evaluate the impact of pesticide exposure on telomere length (TL) and the enzymatic activity of acety…
View article: Single-Cell RNA Sequencing Reveals Extensive Heterogeneity and Unique Gene Trajectories in Non-Transformed and Transformed Human Lung Epithelial Cells: Insights into the Role of LncRNAs in Tumor Heterogeneity
Single-Cell RNA Sequencing Reveals Extensive Heterogeneity and Unique Gene Trajectories in Non-Transformed and Transformed Human Lung Epithelial Cells: Insights into the Role of LncRNAs in Tumor Heterogeneity Open
Lung cancer exhibits substantial inter- and intra-tumor heterogeneity, with features that present significant challenges in advancing biomarker discovery and the development of targeted therapeutics. To fill this gap, we employed single-ce…
View article: A predictive chromatin architecture nexus regulates transcription and DNA damage repair
A predictive chromatin architecture nexus regulates transcription and DNA damage repair Open
Genomes are blueprints of life essential for an organism's survival, propagation, and evolutionary adaptation. Eukaryotic genomes comprise of DNA, core histones, and several other nonhistone proteins, packaged into chromatin in the tiny co…
View article: Genomic and Health Data as Fuel to Advance a Health Data Economy for Artificial Intelligence
Genomic and Health Data as Fuel to Advance a Health Data Economy for Artificial Intelligence Open
Cloud and distributed computing, code repositories, and large language models are democratizing the less computationally intensive use cases of artificial intelligence (AI) in medicine. The convergence and democratization of these powerful…
View article: Modulation of the Oncogenic LINE-1 Regulatory Network in Non-Small Cell Lung Cancer by Exosomal miRNAs
Modulation of the Oncogenic LINE-1 Regulatory Network in Non-Small Cell Lung Cancer by Exosomal miRNAs Open
Several microRNAs (miRNAs), including miR-221-5p, Let-7b-5p, miR-21-5p, miR-9-5p, miR-126-3p, and miR-222-3p, were recently found to be enriched in circulating exosomes of patients with non-small cell lung cancers (NSCLCs). These miRNAs di…
View article: SETD2 as an epigenetic sentinel of transcriptional fidelity in cardiomyocytes: a mechanistic link to heart failure
SETD2 as an epigenetic sentinel of transcriptional fidelity in cardiomyocytes: a mechanistic link to heart failure Open
Epigenetic modulations are pivotal in heart disease progression, yet the specific influence of epigenetic alterations on transcription initiation and elongation in heart failure (HF) is poorly understood. This study focuses on the SETD2-H3…
View article: Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation
Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation Open
SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Supplementary file1 (MP4 8441 KB).
View article: External control arms: COVID-19 reveals the merits of using real world evidence in real-time for clinical and public health investigations
External control arms: COVID-19 reveals the merits of using real world evidence in real-time for clinical and public health investigations Open
Randomized controlled trials are considered the ‘gold standard’ to reduce bias by randomizing patients to an experimental intervention, versus placebo or standard of care cohort. There are inherent challenges to enrolling a standard of car…
View article: Data from Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Data from Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles Open
Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer…
View article: Data from Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Data from Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles Open
Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer…
View article: Data from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen
Data from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen Open
Long interspersed nuclear elements [LINE-1 (L1)] are abundant retrotransposons in mammalian genomes that remain silent under most conditions. Cellular stress signals activate L1, but the molecular mechanisms controlling L1 activation remai…
View article: Data from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen
Data from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen Open
Long interspersed nuclear elements [LINE-1 (L1)] are abundant retrotransposons in mammalian genomes that remain silent under most conditions. Cellular stress signals activate L1, but the molecular mechanisms controlling L1 activation remai…
View article: Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen
Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen Open
Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(a)pyrene, an Ubiquitous Environmental Carcinogen
View article: Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen
Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(<i>a</i>)pyrene, an Ubiquitous Environmental Carcinogen Open
Supplementary Figure 1 from Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo(a)pyrene, an Ubiquitous Environmental Carcinogen
View article: Health equity innovation in precision medicine: Current challenges and future directions
Health equity innovation in precision medicine: Current challenges and future directions Open
OPINION article Front. Public Health, 15 February 2023Sec. Aging and Public Health Volume 11 - 2023 | https://doi.org/10.3389/fpubh.2023.1119736
View article: A comprehensive review of the novel therapeutic targets for the treatment of diabetic cardiomyopathy
A comprehensive review of the novel therapeutic targets for the treatment of diabetic cardiomyopathy Open
Diabetic cardiomyopathy (DCM) is characterized by structural and functional abnormalities in the myocardium affecting people with diabetes. Treatment of DCM focuses on glucose control, blood pressure management, lipid-lowering, and lifesty…
View article: Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy
Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy Open
Precision medicine has emerged as an optimal health-care delivery platform, which emphasizes integration of individual patient characteristics into patient care. For lung cancer, precision approaches have focused mostly on targeted therapi…
View article: Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy
Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy Open
Lung cancer is currently the leading cause of cancer-related deaths worldwide. Significant improvements in lung cancer therapeutics have relied on a better understanding of lung cancer immunity and the development of novel immunotherapies,…
View article: Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles Open
Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer…
View article: An Idealized Clinicogenomic Registry to Engage Underrepresented Populations Using Innovative Technology
An Idealized Clinicogenomic Registry to Engage Underrepresented Populations Using Innovative Technology Open
Current best practices in tumor registries provide a glimpse into a limited time frame over the natural history of disease, usually a narrow window around diagnosis and biopsy. This creates challenges meeting public health and healthcare r…
View article: Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks Open
Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear. Here we report that hyperthermia d…
View article: Limited Genomics Training Among Physicians Remains a Barrier to Genomics-Based Implementation of Precision Medicine
Limited Genomics Training Among Physicians Remains a Barrier to Genomics-Based Implementation of Precision Medicine Open
The field of precision medicine has undergone significant growth over the past 10 years. Despite increasing applications of clinical genetic and genomic testing, studies consistently report limited knowledge of genetics and genomics among …
View article: Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics
Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics Open
From initiation through progression, cancer cells are subjected to a magnitude of endogenous and exogenous stresses, which aid in their neoplastic transformation. Exposure to these classes of stress induces imbalance in cellular homeostasi…