Explanipedia

Evening Chronotype Is Associated With Daytime Impairment and Differential Sleep and Circadian Response to a Sleep Extension Manipulation in Short Sleeping Adolescents Open

Stacey L. Simon, Emily Cooper, Angel Bernard, Anne E. Bowen, Sydney Holtman , et al. · 2025

Adolescents frequently experience insufficient sleep, which can negatively impact physical and mental health. We sought to examine differences in symptoms of insufficient sleep and response to a sleep extension manipulation by chronotype i…

0094 Impact of Insufficient Sleep on Biomarkers of Neurodegeneration and Neuroinflammation in Healthy Adults Open

Erin E. Kishman, Brice V. McConnell, Corey A. Rynders, Lauren Smith, Christina Coughlan , et al. · 2025

Introduction Sleep disturbances are common among individuals with neurodegenerative diseases including Alzheimer’s Disease (AD). Furthermore, sleep disturbances are associated with accelerated cognitive decline and an increased risk of dev…

0279 Impact of Insufficient Sleep on Respiratory Quotient and Substrate Utilization Open

Luisa Pereira Marot, Dana Withrow, Christopher M. Depner, Edward L. Melanson, Janine Higgins , et al. · 2025

Introduction Overeating and insufficient sleep have been reported to increase total daily carbohydrate utilization. Here we evaluated substrate utilization over 24h and specifically during nighttime hours under insufficient sleep condition…

0035 Effect of a Prebiotic Diet on 24-Hour Glucose Levels During Combined Sleep Restriction and Circadian Misalignment Open

Virginia M. Edwards, Sabrina Linton, Christopher M. Depner, Luisa Pereira Marot, Dana Withrow , et al. · 2025

Introduction Insufficient sleep and circadian misalignment dysregulate glucose homeostasis. Interventions are needed for when insufficient sleep and circadian misalignment cannot be avoided (e.g., military operations, emergency responders,…

0005 Duration of the Circadian Biological Night Differs Between Eight and Nine Hour Sleep Opportunities Open

Maeve Sheehy, Rebecca C. Cox, Alivia B. Blumenstein, Tina Burke, Christopher M. Depner , et al. · 2025

Introduction The duration between dim-light melatonin onset and offset represents the biological night, which tracks environmental darkness (i.e., scotoperiod). In humans, melatonin duration is longer after one week of exposure to natural …

0412 Better Objective Sleep in Healthy Adults Is Marked by Increased Bifidobacterium Breve and Saguini Open

Dana Withrow, Kate E. Sprecher, Antonio González, Frank E. Livingston, Ellis Noteboom , et al. · 2025

Introduction Taxa level associations of the human gut microbiota have been reported in relation to sleep health; however, which taxa are associated with good sleep has yet to be determined. Many study methodologies rely on self-reported sl…

Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report Open

Hassan S. Dashti, Erica C. Jansen, Faris M. Zuraikat, Shilpy Dixit, Marishka Brown , et al. · 2025

The circadian system maintains optimal biological functions at the appropriate time of day, and the disruption of this organization can contribute to the pathogenesis of cardiometabolic disorders. The timing of eating is a prominent extern…

Sex Differences in Circadian Timing and Biological Night in Adolescents Open

Armelle Duston, Sydney Holtman, Anne E. Bowen, Melanie Cree‐Green, Kristen J. Nadeau , et al. · 2025

Circadian rhythms, intrinsic 24-h cycles that drive rhythmic changes in behavior and physiology, are important for normal physiology and health. Previous work in adults has identified sex differences in circadian rhythms of melatonin, temp…

A Protocol to Determine Circadian Phase by At‐Home Salivary Dim Light Melatonin Onset Assessment Open

Jade M. Murray, J. Stone, Sabra M. Abbott, Bjørn Bjorvatn, Helen J. Burgess , et al. · 2024

Internal circadian phase assessment is increasingly acknowledged as a critical clinical tool for the diagnosis, monitoring, and treatment of circadian rhythm sleep−wake disorders and for investigating circadian timing in other medical diso…

Circadian misalignment disrupts biomarkers of cardiovascular disease risk and promotes a hypercoagulable state Open

Andrew W. McHill, Edward L. Melanson, Kenneth P. Wright, Christopher M. Depner · 2024

The circadian system regulates 24‐h time‐of‐day patterns of cardiovascular physiology, with circadian misalignment resulting in adverse cardiovascular risk. Although many proteins in the coagulation‐fibrinolysis axis show 24‐h time‐of‐day …

Sleep Extension Does Not Increase Insulin Sensitivity in People With Obesity Who Are Habitual Short-Sleepers Open

Joseph W. Beals, Gordon I. Smith, Sarah S. Farabi, Josiane L. Broussard, Kenneth P. Wright , et al. · 2024

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats Open

Robert S. Thompson, Samuel J. Bowers, Fernando Vargas, Shelby Hopkins, Tel Kelley , et al. · 2024

Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present evidence documenting the dynamic changes in microbial ecology and fecal microbially modified metabo…

Diurnal variation in anxiety and activity is influenced by chronotype and probable anxiety-related disorder status Open

Rebecca C. Cox, Kenneth P. Wright, John Axelsson, Leonie J. T. Balter · 2024

Anxiety symptoms vary moment-to-moment within a day. One factor that may influence these variations is chronotype. Evening chronotypes prefer to engage in activities (e.g., sleep, physical and social activity) later in the day, and evening…

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose <span>Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats Open

Robert S. Thompson, Samuel J. Bowers, Fernando Vargas, Shelby Hopkins, Tel Kelley , et al. · 2024

Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present evidence documenting the dynamic changes in microbial ecology and fecal microbial-modified metaboli…

A perspective on the Festschrift of Charles A. Czeisler, PhD MD Open

Elizabeth B. Klerman, Kenneth P. Wright, Jeanne F. Duffy, Frank A. J. L. Scheer, Anne‐Marie Chang , et al. · 2024

Table of Contents Open

Charles A. Czeisler, Meir H. Kryger, Elizabeth B. Klerman, Kenneth P. Wright, Jeanne F. Duffy , et al. · 2024

Multivariate genome-wide association study of sleep health demonstrates unity and diversity Open

Claire L. Morrison, Evan A. Winiger, Kenneth P. Wright, Naomi P. Friedman · 2023

There has been a recent push to focus sleep research less on disordered sleep and more on the dimensional sleep health. Sleep health incorporates several dimensions of sleep: chronotype, efficiency, daytime alertness, duration, regularity,…

Insufficient sleep and weekend recovery sleep: classification by a metabolomics-based machine learning ensemble Open

Marie Gombert, Nichole Reisdorph, Sarah J. Morton, Kenneth P. Wright, Christopher M. Depner · 2023

Influence of circadian phase and extended wakefulness on glucose levels during forced desynchrony Open

Josiane L. Broussard, Brent C. Knud-Hansen, Scott Grady, Oliver A Knauer, Joseph M. Ronda , et al. · 2023

The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption Open

H. Craig Heller, Erik D. Herzog, Allison J. Brager, Gina R. Poe, Ravi Allada , et al. · 2023

Collegiate athletes must satisfy the academic obligations common to all undergraduates, but they have the additional structural and social stressors of extensive practice time, competition schedules, and frequent travel away from their hom…

Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation Open

Julia M. Gauglitz, Kiana West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon , et al. · 2023

Not simply a matter of parents—Infants’ sleep-wake patterns are associated with their regularity of eating Open

Christophe Mühlematter, Dennis Sandris Nielsen, Josué L. Castro‐Mejía, Steven A. Brown, Björn Rasch , et al. · 2023

In adults there are indications that regular eating patterns are related to better sleep quality. During early development, sleep and eating habits experience major maturational transitions. Further, the bacterial landscape of the gut micr…

Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells Open

Andrew D. Beale, Edward A. Hayter, Priya Crosby, Utham K. Valekunja, Rachel S. Edgar , et al. · 2023

Chronotype and Affective Response to Sleep Restriction and Subsequent Sleep Deprivation Open

Rebecca C. Cox, Hannah Ritchie, Oliver A Knauer, Molly K. Guerin, Ellen R. Stothard , et al. · 2023

Prior research indicates that sleep restriction, sleep deprivation, and circadian misalignment diminish positive affect, whereas effects on negative affect are inconsistent. One potential factor that may influence an individual’s affective…

0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study Open

Taylor Intihar, Margaret Doyle, Molly Lukas, Kenneth P. Wright, Nancy S. Redeker , et al. · 2023

Introduction Bright daytime light, dim evening light, and near darkness during sleep are optimal lighting conditions to support circadian physiology, wakefulness, and sleep. Such light patterns are absent in the medical intensive care unit…

0297 Pathways: A Pilot Study Examining the Impact of Nightshift Work on Obesity and Type 2 Diabetes Risk in Free-Living Shift Workers Open

Kevin Clark, Joseph C. Cleveland, Elizabeth A. Holzhausen, Zachary Stieneker, Joseph Lim , et al. · 2023

Introduction Traditional risk factors for obesity and type 2 diabetes, such as poor diet and low physical activity, cannot fully explain the increased incidence of these diseases. Insufficient sleep and circadian misalignment due to shift …

0163 Impact of cold-water hand immersion on cognitive performance and sleepiness during sleep inertia Open

Matthew Adkins, Rebecca Cox, John Axelsson, Kenneth P. Wright · 2023

Introduction Sleep inertia is a state of impaired cognitive performance upon awakening that dissipates with time awake. Manipulation of the distal-to-proximal skin temperature gradient using cold water has been hypothesized as a potential …

0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU Open

Molly Lukas, Margaret Doyle, Taylor Intihar, Kenneth P. Wright, Nancy S. Redeker , et al. · 2023

Introduction Medical intensive care unit (MICU) light patterns are inadequate for proper circadian alignment. Sleep disruption and circadian misalignment are observed in MICU patients and adversely impact patient outcomes. We sought to est…

0011 Daily verses circadian amplitude of the distal-proximal skin temperature gradient Open

Lidia Ballell, Hannah Ritchie, Oliver A Knauer, Molly Guerin, Ellen R. Stothard , et al. · 2023

Introduction Sleep, circadian rhythms, and thermoregulatory physiology are highly integrated and impact each other. The daily rhythm in the distal-proximal skin temperature gradient (DPG) is wider/more negative during wakefulness, and narr…

0201 Prebiotic Diet Impact on Cognitive Performance, Sleepiness, and Mood During Combined Sleep Restriction and Circadian Misalignment Open

Sarila Ekin, Dana Withrow, Abhignya Kuppa, Kate E. Sprecher, Monika Fleshner , et al. · 2023

Introduction The gut microbiome plays a crucial role in health and affects mood and behavior. The composition and function of the gut microbiome can be modified by prebiotics, which are defined as substrates selectively utilized by host mi…

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