Kenneth K.Y. Cheng
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View article: Subcutaneous white adipose tissue–derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice
Subcutaneous white adipose tissue–derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice Open
Intestinal function and white adipose tissue (WAT) function deteriorate with age, but whether and how their deterioration is intertwined remains unknown. Increased gut permeability, microbiota dysbiosis, and aberrant immune microenvironmen…
View article: Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources
Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources Open
Akkermansia muciniphila and Bifidobacterium spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product…
Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex Open
Emerging evidence suggests that a single bout of physical exercise can induce rapid antidepressant effects, yet the underlying neural mechanisms remain largely unknown. We established a mouse model designed to mimic the mood-elevating effe…
Taurine Alleviates Pancreatic β‐Cell Senescence by Inhibition of p53 Pathway Open
Background Pancreatic β‐cells function deteriorates during aging, leading to increased risk of type 2 diabetes. We and others previously demonstrated that p53 activation triggers β‐cell senescence and dysfunction in aging, but how its acti…
Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis Open
Lipolysis of triglyceride‐rich lipoproteins by peripheral lipoprotein lipase (LPL) plays an essential role in maintaining systemic cholesterol/lipid homeostasis. Human genetic studies have unequivocally demonstrated that activation of LPL …
Branched‐chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases Open
Summary Branched‐chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential for maintaining physiological functions and metabolic homeostasis. However, chronic elevation of BCAAs causes metabolic diseases such as o…
View article: Polygoni Cuspidati Rhizoma et Radix extract activates TFEB and alleviates hepatic steatosis by promoting autophagy
Polygoni Cuspidati Rhizoma et Radix extract activates TFEB and alleviates hepatic steatosis by promoting autophagy Open
Hepatic steatosis, characterized by excessive lipid accumulation in the liver, can be ameliorated by autophagy activation. Polygoni Cuspidati rhizome et Radix (PCRR), traditionally used to treat atherosclerosis, hepatitis, and gallstones, …
The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation Open
Defective glucose-stimulated insulin secretion (GSIS) and β-cell senescence are hallmarks in diabetes. The mitochondrial enzyme pyruvate carboxylase (PC) has been shown to promote GSIS and β-cell proliferation in the clonal β-cell lines, y…
The interplay between the muscle and liver in the regulation of glucolipid metabolism Open
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Polygoni Cuspidati Rhizoma et Radix extract attenuates high-fat diet-induced NAFLD in rats: Impact on untargeted serum metabolomics and liver lipidomics Open
Background: Polygoni Cuspidati Rhizoma et Radix (PCRR; the root and rhizome of Polygonum cuspidatum Sieb. et Zucc) has long been used to treat atherosclerosis, gastrointestinal disorders, and liver disease. However, the underlying mechanis…
Editorial: Metabolic associated fatty liver disease: clinical perspectives from pathogenesis to diagnosis and treatment Open
EDITORIAL article Front. Endocrinol., 30 June 2023Sec. Obesity Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1206642
Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation Open
Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to metabolic‐associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase mur…
A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy Open
NLRP3 (NLR family pyrin domain containing 3) inflammasome is a potent mediator of inflammation due to its ability to produce the pro-inflammatory cytokines IL1B (interleukin 1 beta) and IL18 in response to numerous danger signals and patho…
YY1 regulates glucose homeostasis through controlling insulin transcription in pancreatic beta cells Open
To date, identification of non-islet specific transcriptional factors in the regulation of insulin gene expression has been less studied. Here, we report that the expression level of the transcription factor YY1 has increased dramatically …
YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic Beta Cells Open
To date, identification of non-islet specific transcriptional factors in the regulation of insulin gene expression has been less studied. Here, we report that the expression level of the transcription factor YY1 has increased dramatically …
YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic Beta Cells Open
To date, identification of non-islet specific transcriptional factors in the regulation of insulin gene expression has been less studied. Here, we report that the expression level of the transcription factor YY1 has increased dramatically …
YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells Open
To date, identification of nonislet-specific transcriptional factors in the regulation of insulin gene expression has been little studied. Here, we report that the expression level of the transcription factor YY1 is increased dramatically …
Low‐Density Lipoprotein Receptor‐Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes Open
Early changes in astrocyte energy metabolism are associated with late‐onset Alzheimer's disease (LOAD), but the underlying mechanism remains elusive. A previous study suggested an association between a synonymous SNP (rs1012672, C→T) in LR…
Septic arthritis of the acromioclavicular joint secondary to methicillin-resistant <i>Staphylococcus aureus</i> infection Open
Septic arthritis of the acromioclavicular joint (ACJ) is a rare pathology with very few documented case reports available in the literature. In addition, ACJ septic arthritis secondary to methicillin-resistant Staphylococcus aureus (MRSA) …