Kennichi Kakudo
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View article: Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma
Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma Open
Background: We report a new risk stratification of invasive stage papillary thyroid carcinomas (PTCs) by combining invasive status, using extrathyroid invasion (Ex) status, and tumor growth speed using the Ki-67 labeling index (LI). Method…
View article: Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia
Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia Open
Background: This study was designed to compare diagnostic categories of thyroid fine needle aspiration cytology (FNAC) and incidence of thyroid tumors in the multi-institutional Asian series with a special focus on diagnostic category IV (…
View article: A diagnostic protein assay for differentiating follicular thyroid adenoma and carcinoma
A diagnostic protein assay for differentiating follicular thyroid adenoma and carcinoma Open
Differentiating follicular thyroid adenoma (FTA) from carcinoma (FTC) remains challenging due to similar histological features separate from invasion. In this study, we aim to develop and validate DNA and protein-based classifiers for FTA/…
View article: Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study Open
Background: The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when d…
View article: Review of: "Strategies for Management and Long-term Surveillance of Pediatric Differentiated Thyroid Cancer: Balancing Efficacy and Quality of Life"
Review of: "Strategies for Management and Long-term Surveillance of Pediatric Differentiated Thyroid Cancer: Balancing Efficacy and Quality of Life" Open
Potential competing interests: No potential competing interests to declare.Overall, this is a well-written review article on pediatric thyroid carcinomas, covering both follicular-and C-cell-derived thyroid carcinomas.It summarizes disease…
View article: The Asian Thyroid Working Group, from 2017 to 2023
The Asian Thyroid Working Group, from 2017 to 2023 Open
The Asian Thyroid Working Group was founded in 2017 at the 12th Asia Oceania Thyroid Association (AOTA) Congress in Busan, Korea. This group activity aims to characterize Asian thyroid nodule practice and establish strict diagnostic criter…
View article: Lessons learned from the diversity of thyroid nodule practice
Lessons learned from the diversity of thyroid nodule practice Open
The authors declare no conflicts of interest.
View article: Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach Open
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categoriz…
View article: Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice
Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice Open
Histopathological diagnosis of papillary thyroid carcinomas (PTCs) is prone to significant observer variation due to different thresholds of RAS-like nuclear changes among pathologists. This gap recently widened due to a defensive attitude…
View article: COVID‐19 pandemic impact on cytopathology practice in the post‐lockdown period: An international, multicenter study
COVID‐19 pandemic impact on cytopathology practice in the post‐lockdown period: An international, multicenter study Open
Background In a previous worldwide survey, the authors showed a drastic reduction in the number of cytological specimens processed during the coronavirus disease 2019 “lockdown” period along with an increase in malignancy rates. To assess …
View article: The Differences in Distant Metastatic Patterns and Their Corresponding Survival Between Thyroid Cancer Subtypes
The Differences in Distant Metastatic Patterns and Their Corresponding Survival Between Thyroid Cancer Subtypes Open
Introduction: Distant metastasis (DM) at presentation is one of the important prognostic factors in thyroid cancers. Dissemination patterns of different thyroid cancer subtypes are still controversial. This study aimed to systematically el…
View article: Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods
Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods Open
(1) Background: Accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to a spectrum of cytomorphologic features. However, there is a scarcity of studies describing the cytomorphologic features as seen…
View article: Additional Tissue Sampling Trials Did Not Change Our Thyroid Practice
Additional Tissue Sampling Trials Did Not Change Our Thyroid Practice Open
This study aimed to determine whether additional tissue sampling of encapsulated thyroid nodules would increase the frequency of follicular thyroid carcinoma (FTC) diagnoses. We examined thyroid tissue specimens from 86 patients suspected …
View article: Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms
Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms Open
Our results suggest that NPIs and high nuclear scores have diagnostic utility as rule-in markers for differentiating PTC with BRAFV600E mutation from benign or borderline follicular tumors with RAS-like mutations. Relaxation of rigid crite…
View article: Supplementary Material for: Hyperfunctioning Papillary Thyroid Carcinoma with a <b><i>BRAF</i></b> Mutation: The First Case Report and a Literature Review
Supplementary Material for: Hyperfunctioning Papillary Thyroid Carcinoma with a <b><i>BRAF</i></b> Mutation: The First Case Report and a Literature Review Open
Introduction: Hyperfunctioning papillary thyroid carcinoma (PTC) is rare and consequently, little information on its molecular etiology is available. Although BRAF V600E (BRAF c.1799T>A, p.V600E) is a prominent oncogene in PTC, its mutatio…
View article: Hyperfunctioning Papillary Thyroid Carcinoma with a <b><i>BRAF</i></b> Mutation: The First Case Report and a Literature Review
Hyperfunctioning Papillary Thyroid Carcinoma with a <b><i>BRAF</i></b> Mutation: The First Case Report and a Literature Review Open
Introduction: Hyperfunctioning papillary thyroid carcinoma (PTC) is rare and consequently, little information on its molecular etiology is available. Although BRAF V600E (BRAF c.1799T>A, p.V600E) is a prominent oncogene in PTC, its mu…
View article: Proposal of diagnostic criteria for IgG4-related thyroid disease
Proposal of diagnostic criteria for IgG4-related thyroid disease Open
Patients with IgG4-related disease (IgG4-RD) are diagnosed in Japan by comprehensive or organ-specific diagnostic criteria. To date, organ-specific criteria have been established for several organs, but not for the thyroid. We attempted to…
View article: Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification
Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification Open
Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. Much progress has been made toward avoiding overdiagnosis and overtreatment of thyroid cancers. T…
View article: Global impact of the COVID‐19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries
Global impact of the COVID‐19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries Open
Background To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID‐19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries …
View article: The diversities in thyroid cytopathology practices among Asian countries using the Bethesda system for reporting thyroid cytopathology
The diversities in thyroid cytopathology practices among Asian countries using the Bethesda system for reporting thyroid cytopathology Open
Our study provided insight regarding thyroid cytology practice among Asian countries. Active surveillance is commonly used in Asian practice resulting in a low RR and high ROM for indeterminate nodules. There are still variations in genera…
View article: IgG4 thyroiditis in the Asian population
IgG4 thyroiditis in the Asian population Open
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition that often causes the formation of tumefactive lesions. The discovery of IgG4-RD linked many well-known isolated conditions as a distinct multi-…
View article: Updates in the advances of sporadic medullary thyroid carcinoma: from the molecules to the clinic
Updates in the advances of sporadic medullary thyroid carcinoma: from the molecules to the clinic Open
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy that originates in parafollicular cells. It is well-known that a quarter of MTC are involved in hereditary multiple endocrine neoplasia type 2 syndromes, whereas most MT…
View article: Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population
Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population Open
Objectives We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods Consecutive thyroid fine-needle aspirates (patient age, ≤18 years) were retrosp…
View article: SUN-LB78 Hyperfunctioning Papillary Thyroid Carcinoma With a BRAF Mutation
SUN-LB78 Hyperfunctioning Papillary Thyroid Carcinoma With a BRAF Mutation Open
Background: Hyperfunctioning papillary thyroid carcinoma (PTC) is a rare tumor and accounts for less than 0.1% of all thyroid tumors. Information about its driver mutations is limited. Our literature search yielded 16 cases wherein a mutat…